A reduction of mitochondrial DNA molecules during embryogenesis explains the rapid segregation of genotypes.
about
Keeping mtDNA in shape between generationsMitochondrial gene replacement in primate offspring and embryonic stem cells.Genomic identification in the historical case of the Nicholas II royal familyModulating mitochondrial quality in disease transmission: towards enabling mitochondrial DNA disease carriers to have healthy childrenGenetic manipulation for inherited neurodegenerative diseases: myth or reality?Atypical mitochondrial inheritance patterns in eukaryotesMitochondrial geneticsMitochondrial disorders: challenges in diagnosis & treatmentEvolutionary defined role of the mitochondrial DNA in fertility, disease and ageingDetection of heteroplasmic mitochondrial DNA in single mitochondriaThe Red Queen in mitochondria: cyto-nuclear co-evolution, hybrid breakdown and human diseaseNuclear genome transfer in human oocytes eliminates mitochondrial DNA variantsPolg2 is essential for mammalian embryogenesis and is required for mtDNA maintenanceGimap3 regulates tissue-specific mitochondrial DNA segregationMitochondrial DNA disease and developmental implications for reproductive strategiesToward a mtDNA locus-specific mutation database using the LOVD platformSite heteroplasmy in the mitochondrial cytochrome b gene of the sterlet sturgeon Acipenser ruthenusA thirty million year-old inherited heteroplasmySegregation of Naturally Occurring Mitochondrial DNA Variants in a Mini-Pig ModelCardiac involvement in mitochondrial DNA disease: clinical spectrum, diagnosis, and management.New evidence confirms that the mitochondrial bottleneck is generated without reduction of mitochondrial DNA content in early primordial germ cells of mice.Fluorescent duplex allele-specific PCR and amplicon melting for rapid homogeneous mtDNA haplogroup H screening and sensitive mixture detection.Biomarker Validation for Aging: Lessons from mtDNA Heteroplasmy Analyses in Early Cancer Detection.A wide range of 3243A>G/tRNALeu(UUR) (MELAS) mutation loads may segregate in offspring through the female germline bottleneck.Treatment strategies for inherited optic neuropathies: past, present and futureWhat cost mitochondria? The maintenance of functional mitochondrial DNA within and across generations.Control of mitochondrial integrity in ageing and diseaseRegular bottlenecks and restrictions to somatic fusion prevent the accumulation of mitochondrial defects in NeurosporaTransmission of mitochondrial DNA diseases and ways to prevent them.Mitochondrial DNA variant discovery and evaluation in human Cardiomyopathies through next-generation sequencing.Previous estimates of mitochondrial DNA mutation level variance did not account for sampling error: comparing the mtDNA genetic bottleneck in mice and humans.Regulation of mitochondrial genome inheritance by autophagy and ubiquitin-proteasome system: implications for health, fitness, and fertilityTransmission of mitochondrial mutations and action of purifying selection in Drosophila melanogaster.De novo mtDNA point mutations are common and have a low recurrence risk.Does mtDNA nucleoid organization impact aging?The role of mitochondrial DNA copy number in mammalian fertility.The strength and timing of the mitochondrial bottleneck in salmon suggests a conserved mechanism in vertebrates.Morphological and functional abnormalities in mitochondria associated with synaptic degeneration in prion disease.Very low-level heteroplasmy mtDNA variations are inherited in humansHeteroplasmy of mouse mtDNA is genetically unstable and results in altered behavior and cognition
P2860
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P2860
A reduction of mitochondrial DNA molecules during embryogenesis explains the rapid segregation of genotypes.
description
2008 nî lūn-bûn
@nan
2008 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
name
A reduction of mitochondrial D ...... apid segregation of genotypes.
@ast
A reduction of mitochondrial D ...... apid segregation of genotypes.
@en
A reduction of mitochondrial D ...... apid segregation of genotypes.
@nl
type
label
A reduction of mitochondrial D ...... apid segregation of genotypes.
@ast
A reduction of mitochondrial D ...... apid segregation of genotypes.
@en
A reduction of mitochondrial D ...... apid segregation of genotypes.
@nl
prefLabel
A reduction of mitochondrial D ...... apid segregation of genotypes.
@ast
A reduction of mitochondrial D ...... apid segregation of genotypes.
@en
A reduction of mitochondrial D ...... apid segregation of genotypes.
@nl
P2093
P50
P356
P1433
P1476
A reduction of mitochondrial D ...... apid segregation of genotypes.
@en
P2093
Hans-Henrik M Dahl
Harsha Karur Rajasimha
Jeffrey R Mann
Passorn Wonnapinij
Susana Chuva de Sousa Lopes
P2888
P304
P356
10.1038/NG.2007.63
P407
P577
2008-01-27T00:00:00Z