Peroxynitrite induces destruction of the tetrahydrobiopterin and heme in endothelial nitric oxide synthase: transition from reversible to irreversible enzyme inhibition - Wikidata - awgldk - TriplyDB

Peroxynitrite induces destruction of the tetrahydrobiopterin and heme in endothelial nitric oxide synthase: transition from reversible to irreversible enzyme inhibition

Peroxynitrite induces destruction of the tetrahydrobiopterin and heme in endothelial nitric oxide synthase: transition from reversible to irreversible enzyme inhibition

http://www.wikidata.org/entity/Q33775518

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Neuroinflammation and psychiatric illness Reactive oxygen species in cancer stem cells Neurovascular unit dysfunction with blood-brain barrier hyperpermeability contributes to major depressive disorder: a review of clinical and experimental evidence An ethanolic extract of Lindera obtusiloba stems, YJP-14, improves endothelial dysfunction, metabolic parameters and physical performance in diabetic db/db mice Oxidative Stress Genes, Antioxidants and Coronary Artery Disease in Type 2 Diabetes Mellitus.Grape-derived polyphenols improve aging-related endothelial dysfunction in rat mesenteric artery: role of oxidative stress and the angiotensin system.Mechanism of Nitric Oxide Synthase Regulation: Electron Transfer and Interdomain Interactions.Protein engineering to develop a redox insensitive endothelial nitric oxide synthase Endothelial nitric oxide synthase dimerization is regulated by heat shock protein 90 rather than by phosphorylation.eNOS activation and NO function: structural motifs responsible for the posttranslational control of endothelial nitric oxide synthase activity.Endothelial dysfunction and diabetes: effects on angiogenesis, vascular remodeling, and wound healing.Emerging role of PKA/eNOS pathway in therapeutic angiogenesis for ischaemic tissue diseases Targeting NADPH oxidase decreases oxidative stress in the transgenic sickle cell mouse penis Modulation of myocardial contraction by peroxynitrite Activation of cGMP/protein kinase G pathway in postconditioned myocardium depends on reduced oxidative stress and preserved endothelial nitric oxide synthase coupling Differential effects of the peroxynitrite donor, SIN-1, on atrial and ventricular myocyte electrophysiology.Grape-Derived Polyphenols Prevent Doxorubicin-Induced Blunted EDH-Mediated Relaxations in the Rat Mesenteric Artery: Role of ROS and Angiotensin II Selective up-regulation of arginase-1 in coronary arteries of diabetic patients.Arginase Inhibition Restores Peroxynitrite-Induced Endothelial Dysfunction via L-Arginine-Dependent Endothelial Nitric Oxide Synthase Phosphorylation Redox modulation of endothelial nitric oxide synthase by glutaredoxin-1 through reversible oxidative post-translational modification.The Contrary Impact Of Diabetes And Exercise On Endothelial Nitric Oxide Synthase Function Dissecting regulation mechanism of the FMN to heme interdomain electron transfer in nitric oxide synthases.Peroxynitrite disrupts endothelial caveolae leading to eNOS uncoupling and diminished flow-mediated dilation in coronary arterioles of diabetic patients.Modulating endothelial nitric oxide synthase: a new cardiovascular therapeutic strategy.The mechanisms and physiological relevance of glycocalyx degradation in hepatic ischemia/reperfusion injury.Oxidative stress-related biomarkers in essential hypertension and ischemia-reperfusion myocardial damage.The cGMP/PKG pathway as a common mediator of cardioprotection: translatability and mechanism.Neurovascular Unit Dysfunction and Blood-Brain Barrier Hyperpermeability Contribute to Schizophrenia Neurobiology: A Theoretical Integration of Clinical and Experimental Evidence.Retinal Diseases Associated with Oxidative Stress and the Effects of a Free Radical Scavenger (Edaravone).Angiotensin II impairs endothelial nitric-oxide synthase bioavailability under free cholesterol-enriched conditions via intracellular free cholesterol-rich membrane microdomains.Role of vascular reactive oxygen species in regulating cytochrome P450-4A enzyme expression in Dahl salt-sensitive rats.Lack of Fibronectin Extra Domain A Alternative Splicing Exacerbates Endothelial Dysfunction in Diabetes.Oxygen binding and nitric oxide dioxygenase activity of cytoglobin are altered to different extents by cysteine modification.Cardiac resynchronization therapy and reverse molecular remodeling: importance of mitochondrial redox signaling.S-glutathionylation reshapes our understanding of endothelial nitric oxide synthase uncoupling and nitric oxide/reactive oxygen species-mediated signaling The Characteristics and Regulatory Mechanisms of Superoxide Generation from eNOS Reductase Domain.Redox Control of Vascular Function.Combination therapy with remote ischaemic conditioning and insulin or exenatide enhances infarct size limitation in pigs.Recent novel approaches to limit oxidative stress and inflammation in diabetic complications.

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P2860

Peroxynitrite induces destruction of the tetrahydrobiopterin and heme in endothelial nitric oxide synthase: transition from reversible to irreversible enzyme inhibition

http://www.wikidata.org/entity/Q33775518

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2010 nî lūn-bûn

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2010 թուականի Ապրիլին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի ապրիլին հրատարակված գիտական հոդված

@hy

2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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Peroxynitrite induces destruct ...... irreversible enzyme inhibition

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Peroxynitrite induces destruct ...... irreversible enzyme inhibition

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Peroxynitrite induces destruct ...... irreversible enzyme inhibition

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Peroxynitrite induces destruct ...... irreversible enzyme inhibition

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Peroxynitrite induces destruct ...... irreversible enzyme inhibition

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Peroxynitrite induces destruct ...... irreversible enzyme inhibition

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Ah-Lim Tsai

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Chun-An Chen

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Jay L Zweier

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Lawrence J Druhan

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Vladimir Berka

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Weiguo Chen

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Yeong-Renn Chen

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P2860

Regulation of endothelium-derived nitric oxide production by the protein kinase Akt

Cysteine 99 of endothelial nitric oxide synthase (NOS-III) is critical for tetrahydrobiopterin-dependent NOS-III stability and activity

Characterization of the peroxidase mechanism upon reaction of prostacyclin synthase with peracetic acid. Identification of a tyrosyl radical intermediate

Structural characterization of nitric oxide synthase isoforms reveals striking active-site conservation

Structure of nitric oxide synthase oxygenase dimer with pterin and substrate

Crystal structure of constitutive endothelial nitric oxide synthase: a paradigm for pterin function involving a novel metal center

Subunit interactions of endothelial nitric-oxide synthase. Comparisons to the neuronal and inducible nitric-oxide synthase isoforms

Characterization of bovine endothelial nitric oxide synthase as a homodimer with down-regulated uncoupled NADPH oxidase activity: tetrahydrobiopterin binding kinetics and role of haem in dimerization

Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide

Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly

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10.1021/BI9016632

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14

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49

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20184376

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