Methylation pattern of the O6-methylguanine-DNA methyltransferase gene in colon during progressive colorectal tumorigenesis. - Wikidata - awgldk - TriplyDB

Methylation pattern of the O6-methylguanine-DNA methyltransferase gene in colon during progressive colorectal tumorigenesis.

Methylation pattern of the O6-methylguanine-DNA methyltransferase gene in colon during progressive colorectal tumorigenesis.

http://www.wikidata.org/entity/Q33775531

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Epigenetics of colorectal cancer Toward a Molecular Classification of Colorectal Cancer: The Role of MGMT Research progress on chemopreventive effects of phytochemicals on colorectal cancer and their mechanisms Analysis of fecal DNA methylation to detect gastrointestinal neoplasia.Quantitation of DNA methylation by melt curve analysis.Aberrant gene promoter methylation associated with sporadic multiple colorectal cancer MGMT promoter hypermethylation and K-RAS, PTEN and TP53 mutations in tamoxifen-exposed and non-exposed endometrial cancer cases O6-Methylguanine-DNA methyltransferase protein expression by immunohistochemistry in brain and non-brain systemic tumours: systematic review and meta-analysis of correlation with methylation-specific polymerase chain reaction.O6-methylguanine-DNA methyltransferase in the defense against N-nitroso compounds and colorectal cancer.The nitrosated bile acid DNA lesion O6-carboxymethylguanine is a substrate for the human DNA repair protein O6-methylguanine-DNA methyltransferase.CDK8 expression in 470 colorectal cancers in relation to beta-catenin activation, other molecular alterations and patient survival.Curcumin modulates DNA methylation in colorectal cancer cells.Clinicopathological significance and potential drug target of O6-methylguanine-DNA methyltransferase in colorectal cancer: a meta-analysis.MGMT promoter methylation, loss of expression and prognosis in 855 colorectal cancers.Methylation of MGMT Is Associated with Poor Prognosis in Patients with Stage III Duodenal Adenocarcinoma.Alkylation-induced colon tumorigenesis in mice deficient in the Mgmt and Msh6 proteins Heterogeneous DNA methylation contributes to tumorigenesis through inducing the loss of coexpression connectivity in colorectal cancer.Expansion of epigenetic alterations in EFEMP1 promoter predicts malignant formation in pancreatobiliary intraductal papillary mucinous neoplasms DNA methylation patterns as noninvasive biomarkers and targets of epigenetic therapies in colorectal cancer Gene methylation profiles of normal mucosa, and benign and malignant colorectal tumors identify early onset markers.Promoter methylation in the genesis of gastrointestinal cancer.Correlation of MLH1 and MGMT methylation levels between peripheral blood leukocytes and colorectal tissue DNA samples in colorectal cancer patients.Epigenetic biomarkers in colorectal cancer diagnostics.Prognostic value of MGMT methylation in colorectal cancer: a meta-analysis and literature review.The Mechanism and Function of Epigenetics in Uterine Leiomyoma Development.MGMT in colorectal cancer: a promising component of personalized treatment.DNA repair by MGMT, but not AAG, causes a threshold in alkylation-induced colorectal carcinogenesis.SNP rs16906252C>T Is an Expression and Methylation Quantitative Trait Locus Associated with an Increased Risk of Developing MGMT-Methylated Colorectal Cancer.Base excision repair imbalance in colorectal cancer has prognostic value and modulates response to chemotherapy Effect of Exposure to 900 MHz GSM Mobile Phone Radiofrequency Radiation on Estrogen Receptor Methylation Status in Colon Cells of Male Sprague Dawley Rats.Expression of DNA-repair proteins and their significance in pancreatic cancer and non-cancerous pancreatic tissues of Sprague-Dawley rats.Promoter hypermethylation of RASSF1A, MGMT, and HIC-1 genes in benign and malignant colorectal tumors.The proline rich domain of p53 is dispensable for MGMT-dependent DNA repair and cell survival following alkylation damage.Immunohistochemical staining for p16 and BRAFV600E is useful to distinguish between sporadic and hereditary (Lynch syndrome-related) microsatellite instable colorectal carcinomas.

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Methylation pattern of the O6-methylguanine-DNA methyltransferase gene in colon during progressive colorectal tumorigenesis.

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Methylation pattern of the O6- ...... ssive colorectal tumorigenesis

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Clement Richard Boland

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Hiromi Sasamoto

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Kenji Notohara

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Nagahide Matsubara

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Naoshi Nishida

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Noriaki Tanaka

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Takaomi Takahata

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Takuyuki Uchida

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P2860

O(6)-methylguanine methyltransferase in colorectal cancers: detection of mutations, loss of expression, and weak association with G:C>A:T transitions

Inactivation of the DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents.

MGMT gene silencing and benefit from temozolomide in glioblastoma.

Genetic alterations during colorectal-tumor development

Silencing effect of CpG island hypermethylation and histone modifications on O6-methylguanine-DNA methyltransferase (MGMT) gene expression in human cancer.

Colorectal cancer screening: clinical guidelines and rationale.

MGMT promoter methylation and field defect in sporadic colorectal cancer.

Characterization of the promoter region of the human O6-methylguanine-DNA methyltransferase gene

Aberrant methylations in cancer cells: where do they come from?

Mammalian O6-alkylguanine-DNA alkyltransferase: regulation and importance in response to alkylating carcinogenic and therapeutic agents.

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10.1002/IJC.23398

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11

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122

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Takeshi Nagasaka

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2008-06-01T00:00:00Z

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5612073

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2851179

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