Mammalian O6-alkylguanine-DNA alkyltransferase: regulation and importance in response to alkylating carcinogenic and therapeutic agents.
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The modified human DNA repair enzyme O(6)-methylguanine-DNA methyltransferase is a negative regulator of estrogen receptor-mediated transcription upon alkylation DNA damageReappraisal of the use of procarbazine in the treatment of lymphomas and brain tumorsA CpG island hypermethylation profile of primary colorectal carcinomas and colon cancer cell linesPrediction of Cancer Drug Resistance and Implications for Personalized MedicineThe Saccharomyces cerevisiae MGT1 DNA repair methyltransferase gene: its promoter and entire coding sequence, regulation and in vivo biological functions.DNA mismatch repair in eukaryotes and bacteriaEarly Chk1 phosphorylation is driven by temozolomide-induced, DNA double strand break- and mismatch repair-independent DNA damageMaotai ameliorates diethylnitrosamine-initiated hepatocellular carcinoma formation in miceInfluence of the Expression Level of O6-Alkylguanine-DNA Alkyltransferase on the Formation of DNA Interstrand Crosslinks Induced by Chloroethylnitrosoureas in Cells: A Quantitation Using High-Performance Liquid Chromatography-Mass SpectrometrySeparation of killing and tumorigenic effects of an alkylating agent in mice defective in two of the DNA repair genesA newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity.Atomic Insight into the Altered O6-Methylguanine-DNA Methyltransferase Protein Architecture in Gastric CancerMarked inactivation of O6-alkylguanine-DNA alkyltransferase activity with protracted temozolomide schedulesSequential administration of varying doses of dacarbazine and fotemustine in advanced malignant melanomaThe role of gene body cytosine modifications in MGMT expression and sensitivity to temozolomide.Mismatch repair deficiency does not mediate clinical resistance to temozolomide in malignant gliomaImplication of localization of human DNA repair enzyme O6-methylguanine-DNA methyltransferase at active transcription sites in transcription-repair coupling of the mutagenic O6-methylguanine lesion.Methylation pattern of the O6-methylguanine-DNA methyltransferase gene in colon during progressive colorectal tumorigenesis.Histone/protein deacetylase SIRT1 is an anticancer therapeutic target.Insight into the cooperative DNA binding of the O⁶-alkylguanine DNA alkyltransferase.Role of loss of o⁶-methylguanine dna methyltransferase (MGMT) expression in non-small cell lung carcinomas (NSCLCs): with reference to the relationship with p53 overexpression.Novel approaches to global mining of aberrantly methylated promoter sites in squamous head and neck cancer.Comethylation of p16 and MGMT genes in colorectal carcinoma: correlation with clinicopathological features and prognostic valueLong-term in vitro treatment of human glioblastoma cells with temozolomide increases resistance in vivo through up-regulation of GLUT transporter and aldo-keto reductase enzyme AKR1C expression.Quantitative detection of multiple gene promoter hypermethylation in tumor tissue, serum, and cerebrospinal fluid predicts prognosis of malignant gliomas.Promoter methylation of MGMT, MLH1 and RASSF1A tumor suppressor genes in head and neck squamous cell carcinoma: pharmacological genome demethylation reduces proliferation of head and neck squamous carcinoma cells.Redox-responsive magnetic nanoparticle for targeted convection-enhanced delivery of O6-benzylguanine to brain tumorsA genome-wide miRNA screen revealed miR-603 as a MGMT-regulating miRNA in glioblastomas.Breast cancers with high DSS1 expression that potentially maintains BRCA2 stability have poor prognosis in the relapse-free survivalO(6)-methylguanine-DNA methyltransferase in equine sarcoids: molecular and epigenetic analysis.Regulation of expression of O6-methylguanine-DNA methyltransferase and the treatment of glioblastoma (Review).DNA hypermethylation markers of poor outcome in laryngeal cancer.Altered expression of MGMT in high-grade gliomas results from the combined effect of epigenetic and genetic aberrations.Transcription and DNA damage: a link to a kink.Role of MGMT as biomarker in colorectal cancer.Patients with high-grade gliomas harboring deletions of chromosomes 9p and 10q benefit from temozolomide treatment.Genetic and epigenetic alterations in primary-progressive paired oligodendroglial tumors.Specificities of human, rat and E. coli O6-methylguanine-DNA methyltransferases towards the repair of O6-methyl and O6-ethylguanine in DNA.The molecular significance of methylated BRCA1 promoter in white blood cells of cancer-free females.Establishment, maintenance and in vitro and in vivo applications of primary human glioblastoma multiforme (GBM) xenograft models for translational biology studies and drug discovery.
P2860
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P2860
Mammalian O6-alkylguanine-DNA alkyltransferase: regulation and importance in response to alkylating carcinogenic and therapeutic agents.
description
article científic
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article scientifique
@fr
articol științific
@ro
articolo scientifico
@it
artigo científico
@gl
artigo científico
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artigo científico
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artikel ilmiah
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artikull shkencor
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artículo científico
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name
Mammalian O6-alkylguanine-DNA ...... ogenic and therapeutic agents.
@en
Mammalian O6-alkylguanine-DNA ...... ogenic and therapeutic agents.
@nl
type
label
Mammalian O6-alkylguanine-DNA ...... ogenic and therapeutic agents.
@en
Mammalian O6-alkylguanine-DNA ...... ogenic and therapeutic agents.
@nl
prefLabel
Mammalian O6-alkylguanine-DNA ...... ogenic and therapeutic agents.
@en
Mammalian O6-alkylguanine-DNA ...... ogenic and therapeutic agents.
@nl
P1433
P1476
Mammalian O6-alkylguanine-DNA ...... ogenic and therapeutic agents.
@en
P2093
P304
P407
P577
1990-10-01T00:00:00Z