Monocyclic β-lactams are selective, mechanism-based inhibitors of rhomboid intramembrane proteases
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Activity-based probes for rhomboid proteases discovered in a mass spectrometry-based assayStructure of Rhomboid Protease in Complex with β-Lactam Inhibitors Defines the S2′ Cavityp97-dependent retrotranslocation and proteolytic processing govern formation of active Nrf1 upon proteasome inhibitionStructure and mechanism of rhomboid proteaseThe enzymes of β-lactam biosynthesis.Rhomboids of Mycobacteria: characterization using an aarA mutant of Providencia stuartii and gene deletion in Mycobacterium smegmatisSubstrate binding and specificity of rhomboid intramembrane protease revealed by substrate-peptide complex structuresA new class of rhomboid protease inhibitors discovered by activity-based fluorescence polarizationEnantioselective cis-β-lactam synthesis by intramolecular C-H functionalization from enoldiazoacetamides and derivative donor-acceptor cyclopropenes.Sensitive Versatile Fluorogenic Transmembrane Peptide Substrates for Rhomboid Intramembrane Proteases.The rhomboid protease family: a decade of progress on function and mechanism.Structural and mechanistic principles of intramembrane proteolysis--lessons from rhomboids.Crystal Structures and Inhibition Kinetics Reveal a Two-Stage Catalytic Mechanism with Drug Design Implications for Rhomboid ProteolysisIntramembrane proteases as drug targets.Towards a general synthesis of 3-metal-substituted β-lactams.General and Modular Strategy for Designing Potent, Selective, and Pharmacologically Compliant Inhibitors of Rhomboid Proteases.Embedded in the Membrane: How Lipids Confer Activity and Specificity to Intramembrane Proteases.Discovery and Biological Evaluation of Potent and Selective N-Methylene Saccharin-Derived Inhibitors for Rhomboid Intramembrane Proteases.Stepwise Versus Concerted Mechanisms in General-Base Catalysis by Serine Proteases.
P2860
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P2860
Monocyclic β-lactams are selective, mechanism-based inhibitors of rhomboid intramembrane proteases
description
2011 nî lūn-bûn
@nan
2011 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Monocyclic β-lactams are selec ...... omboid intramembrane proteases
@ast
Monocyclic β-lactams are selec ...... omboid intramembrane proteases
@en
type
label
Monocyclic β-lactams are selec ...... omboid intramembrane proteases
@ast
Monocyclic β-lactams are selec ...... omboid intramembrane proteases
@en
prefLabel
Monocyclic β-lactams are selec ...... omboid intramembrane proteases
@ast
Monocyclic β-lactams are selec ...... omboid intramembrane proteases
@en
P2093
P2860
P356
P1433
P1476
Monocyclic β-lactams are selec ...... omboid intramembrane proteases
@en
P2093
Ela Smiljanic
Jonathan Large
Keith Ansell
Kvido Strisovsky
Matthew Freeman
Nathalie Bouloc
Olivier A Pierrat
Yonka Christova
P2860
P304
P356
10.1021/CB100314Y
P577
2011-01-12T00:00:00Z