Vinblastine induces acute, cell cycle phase-independent apoptosis in some leukemias and lymphomas and can induce acute apoptosis in others when Mcl-1 is suppressed.

Vinblastine induces acute, cell cycle phase-independent apoptosis in some leukemias and lymphomas and can induce acute apoptosis in others when Mcl-1 is suppressed.

Item
http://www.wikidata.org/entity/Q33780816
Thr 163 phosphorylation causes Mcl-1 stabilization when degradation is independent of the adjacent GSK3-targeted phosphodegron, promoting drug resistance in cancerGossypol increases expression of the pro-apoptotic BH3-only protein NOXA through a novel mechanism involving phospholipase A2, cytoplasmic calcium, and endoplasmic reticulum stress.Drugs acting on homeostasis: challenging cancer cell adaptation.Multiple BH3 mimetics antagonize antiapoptotic MCL1 protein by inducing the endoplasmic reticulum stress response and up-regulating BH3-only protein NOXA.Quercetin downregulates Mcl-1 by acting on mRNA stability and protein degradation.Vinblastine sensitizes leukemia cells to cyclin-dependent kinase inhibitors, inducing acute cell cycle phase-independent apoptosisVincristine activates c-Jun N-terminal kinase in chronic lymphocytic leukaemia in vivoRapid induction of apoptosis in chronic lymphocytic leukemia cells by the microtubule disrupting agent BNC105.Cell Cycle-Dependent Mechanisms Underlie Vincristine-Induced Death of Primary Acute Lymphoblastic Leukemia Cells.Vinblastine rapidly induces NOXA and acutely sensitizes primary chronic lymphocytic leukemia cells to ABT-737.The putative BH3 mimetic S1 sensitizes leukemia to ABT-737 by increasing reactive oxygen species, inducing endoplasmic reticulum stress, and upregulating the BH3-only protein NOXA.Natural compounds for pediatric cancer treatment.Microtubule destabilising agents: far more than just antimitotic anticancer drugs.Proteomic profiling identified multiple short-lived members of the central proteome as the direct targets of the addicted oncogenes in cancer cells.JNK and NFκB dependence of apoptosis induced by vinblastine in human acute promyelocytic leukaemia cells.A PDGFRα-driven mouse model of glioblastoma reveals a stathmin1-mediated mechanism of sensitivity to vinblastine
P2860

Vinblastine induces acute, cell cycle phase-independent apoptosis in some leukemias and lymphomas and can induce acute apoptosis in others when Mcl-1 is suppressed.

Item
http://www.wikidata.org/entity/Q33780816
description
2010 nî lūn-bûn
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2010 թուականի Ապրիլին հրատարակուած գիտական յօդուած
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2010 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2010年の論文
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2010年論文
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2010年論文
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2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
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2010年论文
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name
Vinblastine induces acute, cel ...... hers when Mcl-1 is suppressed.
@ast
Vinblastine induces acute, cel ...... hers when Mcl-1 is suppressed.
@en
type
label
Vinblastine induces acute, cel ...... hers when Mcl-1 is suppressed.
@ast
Vinblastine induces acute, cel ...... hers when Mcl-1 is suppressed.
@en
prefLabel
Vinblastine induces acute, cel ...... hers when Mcl-1 is suppressed.
@ast
Vinblastine induces acute, cel ...... hers when Mcl-1 is suppressed.
@en
P1433
P1476
P2093
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P304
P31
P356
P433
P478
P577
P5875
P698
P932
P356
P1433
P1476
Vinblastine induces acute, cel ...... hers when Mcl-1 is suppressed.
@en
P2093
P2860
P304
P31
P356
10.1158/1535-7163.MCT-10-0028
P433
P478
P577
P5875
P698
P932