The impact of multidideoxynucleoside resistance-conferring mutations in human immunodeficiency virus type 1 reverse transcriptase on polymerase fidelity and error specificity
about
Mechanistic differences in RNA-dependent DNA polymerization and fidelity between murine leukemia virus and HIV-1 reverse transcriptasesDifferential in vitro kinetics of drug resistance mutation acquisition in HIV-1 RT of subtypes B and CMutations in HIV-1 reverse transcriptase affect the errors made in a single cycle of viral replication.Development of an in vivo assay to identify structural determinants in murine leukemia virus reverse transcriptase important for fidelityEffects of amino acid substitutions at position 115 on the fidelity of human immunodeficiency virus type 1 reverse transcriptaseMutants of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase resistant to nonnucleoside reverse transcriptase inhibitors demonstrate altered rates of RNase H cleavage that correlate with HIV-1 replication fitness in cell culture.The influence of 3TC resistance mutation M184I on the fidelity and error specificity of human immunodeficiency virus type 1 reverse transcriptase.The reverse transcriptase encoded by the non-LTR retrotransposon R2 is as error-prone as that encoded by HIV-1Analysis of mutations at positions 115 and 116 in the dNTP binding site of HIV-1 reverse transcriptase.A Novel Leu92 Mutant of HIV-1 Reverse Transcriptase with a Selective Deficiency in Strand Transfer Causes a Loss of Viral Replication.A positively charged side chain at position 154 on the beta8-alphaE loop of HIV-1 RT is required for stable ternary complex formation.In vitro fidelity of the prototype primate foamy virus (PFV) RT compared to HIV-1 RT.Mutation rates and intrinsic fidelity of retroviral reverse transcriptases.Biochemical characterization of a multi-drug resistant HIV-1 subtype AG reverse transcriptase: antagonism of AZT discrimination and excision pathways and sensitivity to RNase H inhibitors.Mutation patterns of the reverse transcriptase and protease genes in human immunodeficiency virus type 1-infected patients undergoing combination therapy: survey of 787 sequences.A mutation in the primer grip region of HIV-1 reverse transcriptase that confers reduced fidelity of DNA synthesisAltered error specificity of RNase H-deficient HIV-1 reverse transcriptases during DNA-dependent DNA synthesis.Hypersusceptibility to substrate analogs conferred by mutations in human immunodeficiency virus type 1 reverse transcriptase.Transcriptional inaccuracy threshold attenuates differences in RNA-dependent DNA synthesis fidelity between retroviral reverse transcriptases.
P2860
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P2860
The impact of multidideoxynucleoside resistance-conferring mutations in human immunodeficiency virus type 1 reverse transcriptase on polymerase fidelity and error specificity
description
1998 nî lūn-bûn
@nan
1998 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
The impact of multidideoxynucl ...... fidelity and error specificity
@ast
The impact of multidideoxynucl ...... fidelity and error specificity
@en
type
label
The impact of multidideoxynucl ...... fidelity and error specificity
@ast
The impact of multidideoxynucl ...... fidelity and error specificity
@en
prefLabel
The impact of multidideoxynucl ...... fidelity and error specificity
@ast
The impact of multidideoxynucl ...... fidelity and error specificity
@en
P2093
P2860
P1433
P1476
The impact of multidideoxynucl ...... fidelity and error specificity
@en
P2093
P2860
P304
P577
1998-04-01T00:00:00Z