Therapeutic enzyme deimmunization by combinatorial T-cell epitope removal using neutral drift
about
Prevention of influenza by targeting host receptors using engineered proteinsIn silico study of rotavirus VP7 surface accessible conserved regions for antiviral drug/vaccine designMapping the Pareto optimal design space for a functionally deimmunized biotherapeutic candidateAmino acid deprivation using enzymes as a targeted therapy for cancer and viral infectionsRemoving T-cell epitopes with computational protein design.Computationally driven deletion of broadly distributed T cell epitopes in a biotherapeutic candidate.HLA-DRB1*07:01 is associated with a higher risk of asparaginase allergies.Protein deimmunization via structure-based design enables efficient epitope deletion at high mutational loadsElimination of murine and human T-cell epitopes in recombinant immunotoxin eliminates neutralizing and anti-drug antibodies in vivo.Immunogenicity to biologics: mechanisms, prediction and reduction.SCHEMA-designed variants of human Arginase I and II reveal sequence elements important to stability and catalysis.GFP reporter screens for the engineering of amino acid degrading enzymes from libraries expressed in bacteria.Effect of premedications in a murine model of asparaginase hypersensitivityDepletion of T cell epitopes in lysostaphin mitigates anti-drug antibody response and enhances antibacterial efficacy in vivo.Structure-based redesign of lysostaphin yields potent antistaphylococcal enzymes that evade immune cell surveillance.Toward reducing immunogenicity of enzyme replacement therapy: altering the specificity of human β-glucuronidase to compensate for α-iduronidase deficiency.Predictions versus high-throughput experiments in T-cell epitope discovery: competition or synergy?The utility and limitations of current Web-available algorithms to predict peptides recognized by CD4 T cells in response to pathogen infectionPoor correlation between T-cell activation assays and HLA-DR binding prediction algorithms in an immunogenic fragment of Pseudomonas exotoxin A.EpiSweep: Computationally Driven Reengineering of Therapeutic Proteins to Reduce Immunogenicity While Maintaining Function.Design and analysis of immune-evading enzymes for ADEPT therapy.Computationally optimized deimmunization libraries yield highly mutated enzymes with low immunogenicity and enhanced activity.Identification and elimination of an immunodominant T-cell epitope in recombinant immunotoxins based on Pseudomonas exotoxin A.Immunogenicity of therapeutic recombinant immunotoxins.Clonostachys rosea demethiolase STR3 controls the conversion of methionine into methanethiolscFv-based "Grababody" as a general strategy to improve recruitment of immune effector cells to antibody-targeted tumors.Mutations in subunit interface and B-cell epitopes improve antileukemic activities of Escherichia coli asparaginase-II: evaluation of immunogenicity in mice.Targeting methionine auxotrophy in cancer: discovery & exploration.Drug development: longer-lived proteins.Rational design of low immunogenic anti CD25 recombinant immunotoxin for T cell malignancies by elimination of T cell epitopes in PE38.Novel in silico tools for designing peptide-based subunit vaccines and immunotherapeutics.Targeting Cancer Metabolism: Dietary and Pharmacologic Interventions.Design and engineering of deimmunized biotherapeutics.The role of immune tolerance induction in restoration of the efficacy of ERT in Pompe disease.A high throughput MHC II binding assay for quantitative analysis of peptide epitopes.Studies on Deimmunization of Antileukaemic L-Asparaginase to have Reduced Clinical Immunogenicity--An in silico Approach.Discovery of human-like L-asparaginases with potential clinical use by directed evolution.Structure-based redesign of proteins for minimal T-cell epitope contentRhizobium etli asparaginase II: an alternative for acute lymphoblastic leukemia (ALL) treatment.L-methionase: a therapeutic enzyme to treat malignancies.
P2860
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P2860
Therapeutic enzyme deimmunization by combinatorial T-cell epitope removal using neutral drift
description
2011 nî lūn-bûn
@nan
2011 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Therapeutic enzyme deimmunizat ...... pe removal using neutral drift
@ast
Therapeutic enzyme deimmunizat ...... pe removal using neutral drift
@en
type
label
Therapeutic enzyme deimmunizat ...... pe removal using neutral drift
@ast
Therapeutic enzyme deimmunizat ...... pe removal using neutral drift
@en
prefLabel
Therapeutic enzyme deimmunizat ...... pe removal using neutral drift
@ast
Therapeutic enzyme deimmunizat ...... pe removal using neutral drift
@en
P2093
P2860
P356
P1476
Therapeutic enzyme deimmunizat ...... pe removal using neutral drift
@en
P2093
Aakanksha Dixit
Brent L Iverson
George Georgiou
Jason R Cantor
Tae Hyeon Yoo
P2860
P304
P356
10.1073/PNAS.1014739108
P407
P577
2011-01-05T00:00:00Z