Alcohol-induced motor impairment caused by increased extrasynaptic GABA(A) receptor activity. - Wikidata - awgldk - TriplyDB

Alcohol-induced motor impairment caused by increased extrasynaptic GABA(A) receptor activity.

Alcohol-induced motor impairment caused by increased extrasynaptic GABA(A) receptor activity.

http://www.wikidata.org/entity/Q33787183

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Ethanol acts directly on extrasynaptic subtypes of GABAA receptors to increase tonic inhibition Low-dose alcohol actions on alpha4beta3delta GABAA receptors are reversed by the behavioral alcohol antagonist Ro15-4513 Ethanol potently and competitively inhibits binding of the alcohol antagonist Ro15-4513 to alpha4/6beta3delta GABAA receptors International Union of Pharmacology. LXX. Subtypes of gamma-aminobutyric acid(A) receptors: classification on the basis of subunit composition, pharmacology, and function. Update Potentiation of Gamma Aminobutyric Acid Receptors (GABAAR) by Ethanol: How Are Inhibitory Receptors Affected?A Genetic Animal Model of Alcoholism for Screening Medications to Treat Addiction.Rat alpha6beta2delta GABAA receptors exhibit two distinct and separable agonist affinities Contributions of the GABAA receptor alpha6 subunit to phasic and tonic inhibition revealed by a naturally occurring polymorphism in the alpha6 gene Presynaptic GABAA receptors facilitate GABAergic transmission to dopaminergic neurons in the ventral tegmental area of young rats Synaptic effects induced by alcohol.The GABAergic deficit hypothesis of major depressive disorder.Neurosteroid influences on sensitivity to ethanol Ethanol effects on GABA-gated current in a model of increased alpha4betadelta GABAA receptor expression depend on time course and preexposure to low concentrations of the drug.Opposite actions of alcohol on tonic GABA(A) receptor currents mediated by nNOS and PKC activity.The role of GABA(A) receptors in the acute and chronic effects of ethanol: a decade of progress Numerous classes of general anesthetics inhibit etomidate binding to gamma-aminobutyric acid type A (GABAA) receptors.Low dose acute alcohol effects on GABA A receptor subtypes GABAA receptor subtypes: the "one glass of wine" receptors.Neurosteroids and GABAergic signaling in health and disease Stoichiometry of expressed alpha(4)beta(2)delta gamma-aminobutyric acid type A receptors depends on the ratio of subunit cDNA transfected.Altered GABAergic Signaling in Brain Disease at Various Stages of Life.A major QTL for acute ethanol sensitivity in the alcohol tolerant and non-tolerant selected rat lines Molecular targets and mechanisms for ethanol action in glycine receptors Normal acute behavioral responses to moderate/high dose ethanol in GABAA receptor alpha 4 subunit knockout mice.Alcohol selectivity of β3-containing GABAA receptors: evidence for a unique extracellular alcohol/imidazobenzodiazepine Ro15-4513 binding site at the α+β- subunit interface in αβ3δ GABAA receptors.Alcohol excites cerebellar Golgi cells by inhibiting the Na+/K+ ATPase Alcohol use disorders and current pharmacological therapies: the role of GABA(A) receptors.Modulation of GABAergic and glutamatergic transmission by ethanol in the developing neocortex: an in vitro test of the excessive inhibition hypothesis of fetal alcohol spectrum disorder.Site-specific microinjection of Gaboxadol into the infralimbic cortex modulates ethanol intake in male C57BL/6J mice.Basis of the gabamimetic profile of ethanol.Alcohol- and alcohol antagonist-sensitive human GABAA receptors: tracking δ subunit incorporation into functional receptors.GABA(A) receptors in the dorsal raphé nucleus of mice: escalation of aggression after alcohol consumption.SB-205384 is a positive allosteric modulator of recombinant GABAA receptors containing rat α3, α5, or α6 subunit subtypes coexpressed with β3 and γ2 subunits.The neurobiology of alcohol consumption and alcoholism: an integrative history The pharmacogenetics of alcohol use disorder Ro 15-4513 Antagonizes Alcohol-Induced Sedation in Mice Through αβγ2-type GABA(A) Receptors.Emerging strategies in the management of essential tremor.Glycine and GABA(A) ultra-sensitive ethanol receptors as novel tools for alcohol and brain research.Extrasynaptic delta-containing GABAA receptors in the nucleus accumbens dorsomedial shell contribute to alcohol intake.Plasticity of GABAA receptors after ethanol pre-exposure in cultured hippocampal neurons.

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P2860

Alcohol-induced motor impairment caused by increased extrasynaptic GABA(A) receptor activity.

http://www.wikidata.org/entity/Q33787183

description

2005 nî lūn-bûn

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2005 թուականի Փետրուարին հրատարակուած գիտական յօդուած

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2005 թվականի փետրվարին հրատարակված գիտական հոդված

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2005年の論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年论文

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name

Alcohol-induced motor impairme ...... tic GABA(A) receptor activity.

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Alcohol-induced motor impairme ...... tic GABA(A) receptor activity.

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type

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Alcohol-induced motor impairme ...... tic GABA(A) receptor activity.

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Alcohol-induced motor impairme ...... tic GABA(A) receptor activity.

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Alcohol-induced motor impairme ...... tic GABA(A) receptor activity.

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Nature Neuroscience

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Alcohol-induced motor impairme ...... tic GABA(A) receptor activity.

@en

P2093

H Jacob Hanchar

http://www.w3.org/2001/XMLSchema#string

Martin Wallner

http://www.w3.org/2001/XMLSchema#string

Paul D Dodson

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Richard W Olsen

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Thomas S Otis

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P2860

A central role of the BK potassium channel in behavioral responses to ethanol in C. elegans

Segregation of different GABAA receptors to synaptic and extrasynaptic membranes of cerebellar granule cells

G-protein-coupled inwardly rectifying potassium channels are targets of alcohol action

Ethanol opens G-protein-activated inwardly rectifying K+ channels

Mice devoid of gamma-aminobutyrate type A receptor beta3 subunit have epilepsy, cleft palate, and hypersensitive behavior

Subunit composition and quantitative importance of GABA(A) receptor subtypes in the cerebellum of mouse and rat

Paradoxical reduction of synaptic inhibition by vigabatrin

Hormonally regulated alpha(4)beta(2)delta GABA(A) receptors are a target for alcohol.

Expression of GABA(A) receptor subunits in rat brainstem auditory pathways: cochlear nuclei, superior olivary complex and nucleus of the lateral lemniscus.

Neuroactive steroids reduce neuronal excitability by selectively enhancing tonic inhibition mediated by delta subunit-containing GABAA receptors.

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10.1038/NN1398

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3

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8036833

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15696164

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2854077

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