Numerous classes of general anesthetics inhibit etomidate binding to gamma-aminobutyric acid type A (GABAA) receptors. - Wikidata - awgldk - TriplyDB

Numerous classes of general anesthetics inhibit etomidate binding to gamma-aminobutyric acid type A (GABAA) receptors.

Numerous classes of general anesthetics inhibit etomidate binding to gamma-aminobutyric acid type A (GABAA) receptors.

http://www.wikidata.org/entity/Q33726384

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The concept of allosteric interaction and its consequences for the chemistry of the brain The molecular pharmacology of volatile anesthetics Mapping general anesthetic binding site(s) in human α1β3 γ-aminobutyric acid type A receptors with [³H]TDBzl-etomidate, a photoreactive etomidate analogue Mutations at beta N265 in γ-aminobutyric acid type A receptors alter both binding affinity and efficacy of potent anesthetics Atomistic insights into human Cys-loop receptors by solution NMR.GABA(A) receptor transmembrane amino acids are critical for alcohol action: disulfide cross-linking and alkyl methanethiosulfonate labeling reveal relative location of binding sites Specificity of intersubunit general anesthetic-binding sites in the transmembrane domain of the human α1β3γ2 γ-aminobutyric acid type A (GABAA) receptor.A transmembrane amino acid in the GABAA receptor β2 subunit critical for the actions of alcohols and anesthetics.A propofol binding site on mammalian GABAA receptors identified by photolabeling Flavonoid modulation of GABA(A) receptors.Anesthetic sites and allosteric mechanisms of action on Cys-loop ligand-gated ion channels.A Single phenylalanine residue in the main intracellular loop of α1 γ-aminobutyric acid type A and glycine receptors influences their sensitivity to propofol.Engineering a prokaryotic Cys-loop receptor with a third functional domain.Allosteric regulation of pentameric ligand-gated ion channels: an emerging mechanistic perspective An allosteric coagonist model for propofol effects on α1β2γ2L γ-aminobutyric acid type A receptors.Dihydromyricetin as a novel anti-alcohol intoxication medication.Flavan-3-ol esters: new agents for exploring modulatory sites on GABA(A) receptors.Identification and characterization of anesthetic targets by mouse molecular genetics approaches.Gating-induced conformational rearrangement of the γ-aminobutyric acid type A receptor β-α subunit interface in the membrane-spanning domain A Cysteine Substitution Probes β3H267 Interactions with Propofol and Other Potent Anesthetics in α1β3γ2L γ-Aminobutyric Acid Type A Receptors Effects of inhaled anesthetic isoflurane on long-term potentiation of CA3 pyramidal cell afferents in vivo p-(4-Azipentyl)propofol: a potent photoreactive general anesthetic derivative of propofol.Propofol, but not etomidate, increases corticosterone levels and induces long-term alteration in hippocampal synaptic activity in neonatal rats.State-dependent etomidate occupancy of its allosteric agonist sites measured in a cysteine-substituted GABAA receptor.Inter- and Intra-Subunit Butanol/Isoflurane Sites of Action in the Human Glycine Receptor.Allyl m-trifluoromethyldiazirine mephobarbital: an unusually potent enantioselective and photoreactive barbiturate general anesthetic.Cysteine substitutions define etomidate binding and gating linkages in the α-M1 domain of γ-aminobutyric acid type A (GABAA) receptors Awake nonhuman primate brain PET imaging with minimal head restraint: evaluation of GABAA-benzodiazepine binding with 11C-flumazenil in awake and anesthetized animals.Neonatal Propofol and Etomidate Exposure Enhance Inhibitory Synaptic Transmission in Hippocampal Cornus Ammonis 1 Pyramidal Neurons.Mechanisms revealed through general anesthetic photolabeling.Structural models of ligand-gated ion channels: sites of action for anesthetics and ethanol.Seeking structural specificity: direct modulation of pentameric ligand-gated ion channels by alcohols and general anesthetics.GABA(A) receptors as molecular targets of general anesthetics: identification of binding sites provides clues to allosteric modulation.A novel GABA(A) receptor pharmacology: drugs interacting with the α(+) β(-) interface.Harnessing allostery: a novel approach to drug discovery.Shedding Light on Anesthetic Mechanisms: Application of Photoaffinity Ligands.Mapping General Anesthetic Sites in Heteromeric γ-Aminobutyric Acid Type A Receptors Reveals a Potential For Targeting Receptor Subtypes.Mechanism of Allosteric Modulation of the Cys-loop Receptors.Structural Studies of GABAA Receptor Binding Sites: Which Experimental Structure Tells us What?Multiple transmembrane binding sites for p-trifluoromethyldiazirinyl-etomidate, a photoreactive Torpedo nicotinic acetylcholine receptor allosteric inhibitor.

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Numerous classes of general anesthetics inhibit etomidate binding to gamma-aminobutyric acid type A (GABAA) receptors.

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2010 թուականի Յունուարին հրատարակուած գիտական յօդուած

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2010 թվականի հունվարին հրատարակված գիտական հոդված

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2010年の論文

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Numerous classes of general an ...... acid type A (GABAA) receptors.

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Journal of Biological Chemistry

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Numerous classes of general an ...... acid type A (GABAA) receptors.

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David C Chiara

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Guo-Dong Li

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Jonathan B Cohen

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Richard W Olsen

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P2860

International Union of Pharmacology. LXX. Subtypes of gamma-aminobutyric acid(A) receptors: classification on the basis of subunit composition, pharmacology, and function. Update

Refined structure of the nicotinic acetylcholine receptor at 4A resolution

Methionine 286 in transmembrane domain 3 of the GABAA receptor beta subunit controls a binding cavity for propofol and other alkylphenol general anesthetics

Alcohol-induced motor impairment caused by increased extrasynaptic GABA(A) receptor activity.

Anesthetics and ion channels: molecular models and sites of action.

Sites of alcohol and volatile anaesthetic action on GABA(A) and glycine receptors.

Comparative models of GABAA receptor extracellular and transmembrane domains: important insights in pharmacology and function.

Specific binding sites for alcohols and anesthetics on ligand-gated ion channels.

Endogenous neurosteroids regulate GABAA receptors through two discrete transmembrane sites.

Chemokine production by human vascular smooth muscle cells: modulation by IL-13

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