Mechanisms for adaptation of simian immunodeficiency virus to replication in alveolar macrophages
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cis Expression of DC-SIGN allows for more efficient entry of human and simian immunodeficiency viruses via CD4 and a coreceptorLoss of a tyrosine-dependent trafficking motif in the simian immunodeficiency virus envelope cytoplasmic tail spares mucosal CD4 cells but does not prevent disease progression.Modeling HIV quasispecies evolutionary dynamics.Interaction with CD4 and antibodies to CD4-induced epitopes of the envelope gp120 from a microglial cell-adapted human immunodeficiency virus type 1 isolateMacrophage tropism of human immunodeficiency virus type 1 isolates from brain and lymphoid tissues predicts neurotropism independent of coreceptor specificity.Differential CD4/CCR5 utilization, gp120 conformation, and neutralization sensitivity between envelopes from a microglia-adapted human immunodeficiency virus type 1 and its parental isolate.Ability of the V3 loop of simian immunodeficiency virus to serve as a target for antibody-mediated neutralization: correlation of neutralization sensitivity, growth in macrophages, and decreased dependence on CD4Relationships between CD4 independence, neutralization sensitivity, and exposure of a CD4-induced epitope in a human immunodeficiency virus type 1 envelope protein.Influence of glycosylation on the efficacy of an Env-based vaccine against simian immunodeficiency virus SIVmac239 in a macaque AIDS modelAdoption of an "open" envelope conformation facilitating CD4 binding and structural remodeling precedes coreceptor switch in R5 SHIV-infected macaques.Amino acid deletions are introduced into the V2 region of gp120 during independent pathogenic simian immunodeficiency virus/HIV chimeric virus (SHIV) infections of rhesus monkeys generating variants that are macrophage tropic.Variation in the biological properties of HIV-1 R5 envelopes: implications of envelope structure, transmission and pathogenesis.Macrophage-tropic simian/human immunodeficiency virus chimeras use CXCR4, not CCR5, for infections of rhesus macaque peripheral blood mononuclear cells and alveolar macrophagesDiversity of envelope genes from an uncloned stock of SIVmac251.Increased CCR5 affinity and reduced CCR5/CD4 dependence of a neurovirulent primary human immunodeficiency virus type 1 isolate.Rapid progression to simian AIDS can be accompanied by selection of CD4-independent gp120 variants with impaired ability to bind CD4.Importance of B-cell responses for immunological control of variant strains of simian immunodeficiency virus.A conserved determinant in the V1 loop of HIV-1 modulates the V3 loop to prime low CD4 use and macrophage infection.Unique pattern of convergent envelope evolution in simian immunodeficiency virus-infected rapid progressor macaques: association with CD4-independent usage of CCR5.The HIV Env variant N283 enhances macrophage tropism and is associated with brain infection and dementia.Cell tropism of simian immunodeficiency virus in culture is not predictive of in vivo tropism or pathogenesisSystematic analysis of intracellular trafficking motifs located within the cytoplasmic domain of simian immunodeficiency virus glycoprotein gp41Restricted SIV replication in rhesus macaque lung tissues during the acute phase of infectionUnique pathology in simian immunodeficiency virus-infected rapid progressor macaques is consistent with a pathogenesis distinct from that of classical AIDS.Characterization and Implementation of a Diverse Simian Immunodeficiency Virus SIVsm Envelope Panel in the Assessment of Neutralizing Antibody Breadth Elicited in Rhesus Macaques by Multimodal Vaccines Expressing the SIVmac239 Envelope.Although macrophage-tropic simian/human immunodeficiency viruses can exhibit a range of pathogenic phenotypes, a majority of isolates induce no clinical disease in immunocompetent macaques.Lineage-specific differences between human and simian immunodeficiency virus regulation of gp120 trimer association and CD4 bindingAnalysis of SIVmac Envelope-Specific Antibodies Selected Through Phage Display.Adaptation of the human immunodeficiency virus type 1 envelope glycoproteins to new world monkey receptors.Identification of interdependent variables that influence coreceptor switch in R5 SHIV(SF162P3N)-infected macaques.Efficient transmission and persistence of low-frequency SIVmac251 variants in CD8-depleted rhesus macaques with different neuropathology.Derivation and Characterization of a CD4-Independent, Non-CD4-Tropic Simian Immunodeficiency Virus.The V1-V3 region of a brain-derived HIV-1 envelope glycoprotein determines macrophage tropism, low CD4 dependence, increased fusogenicity and altered sensitivity to entry inhibitorsA single amino acid change and truncated TM are sufficient for simian immunodeficiency virus to enter cells using CCR5 in a CD4-independent pathway.Adaptive evolution of simian immunodeficiency viruses isolated from 2 conventional-progressor macaques with encephalitis.Intrathecal humoral responses are inversely associated with the frequency of simian immunodeficiency virus macrophage-tropic variants in the central nervous systemConformational HIV-1 envelope on particulate structures: a tool for chemokine coreceptor binding studies.Simian Immunodeficiency Virus SIVmac239, but Not SIVmac316, Binds and Utilizes Human CD4 More Efficiently than Rhesus CD4.Identification of Emerging Macrophage-Tropic HIV-1 R5 Variants in Brain Tissue of AIDS Patients without Severe Neurological Complications.Histidine 375 Modulates CD4 Binding in HIV-1 CRF01_AE Envelope Glycoproteins.
P2860
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P2860
Mechanisms for adaptation of simian immunodeficiency virus to replication in alveolar macrophages
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2000 nî lūn-bûn
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2000 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
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2000 թվականի նոյեմբերին հրատարակված գիտական հոդված
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2000年の論文
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2000年論文
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2000年論文
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2000年論文
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2000年論文
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2000年論文
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2000年论文
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name
Mechanisms for adaptation of s ...... cation in alveolar macrophages
@ast
Mechanisms for adaptation of s ...... cation in alveolar macrophages
@en
type
label
Mechanisms for adaptation of s ...... cation in alveolar macrophages
@ast
Mechanisms for adaptation of s ...... cation in alveolar macrophages
@en
prefLabel
Mechanisms for adaptation of s ...... cation in alveolar macrophages
@ast
Mechanisms for adaptation of s ...... cation in alveolar macrophages
@en
P2093
P2860
P1433
P1476
Mechanisms for adaptation of s ...... cation in alveolar macrophages
@en
P2093
M Rosenzweig
R C Desrosiers
P2860
P304
10852-10859
P356
10.1128/JVI.74.22.10852-10859.2000
P577
2000-11-01T00:00:00Z