High-level resistance to (-) enantiomeric 2'-deoxy-3'-thiacytidine in vitro is due to one amino acid substitution in the catalytic site of human immunodeficiency virus type 1 reverse transcriptase
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Lamivudine (3TC) resistance in HIV-1 reverse transcriptase involves steric hindrance with beta-branched amino acidsApricitabine does not select additional drug resistance mutations in tissue culture in human immunodeficiency virus type 1 variants containing K65R, M184V, or M184V plus thymidine analogue mutationsA new point mutation (P157S) in the reverse transcriptase of human immunodeficiency virus type 1 confers low-level resistance to (-)-beta-2',3'-dideoxy-3'-thiacytidineIn vitro induction of human immunodeficiency virus type 1 variants resistant to phosphoralaninate prodrugs of Z-methylenecyclopropane nucleoside analoguesAntiviral activity of 2'-deoxy-3'-oxa-4'-thiocytidine (BCH-10652) against lamivudine-resistant human immunodeficiency virus type 1 in SCID-hu Thy/Liv miceSelection and characterization of human immunodeficiency virus type 1 variants resistant to the (+) and (-) enantiomers of 2'-deoxy-3'-oxa-4'-thio-5-fluorocytidineAnti-human immunodeficiency virus activities of the beta-L enantiomer of 2',3'-dideoxycytidine and its 5-fluoro derivative in vitroCombination of mutations in human immunodeficiency virus type 1 reverse transcriptase required for resistance to the carbocyclic nucleoside 1592U89Significance of amino acid variation at human immunodeficiency virus type 1 reverse transcriptase residue 210 for zidovudine susceptibilityIdentification of BMS-200475 as a potent and selective inhibitor of hepatitis B virusThe nucleoside analog-resistant E89G mutant of human immunodeficiency virus type 1 reverse transcriptase displays a broader cross-resistance that extends to nonnucleoside inhibitorsA novel polymorphism at codon 333 of human immunodeficiency virus type 1 reverse transcriptase can facilitate dual resistance to zidovudine and L-2',3'-dideoxy-3'-thiacytidineN348I in the connection domain of HIV-1 reverse transcriptase confers zidovudine and nevirapine resistanceA synthetic HIV-1 subtype C backbone generates comparable PR and RT resistance profiles to a subtype B backbone in a recombinant virus assayA polymorphism at position 400 in the connection subdomain of HIV-1 reverse transcriptase affects sensitivity to NNRTIs and RNaseH activityMechanistic characterization and molecular modeling of hepatitis B virus polymerase resistance to entecavirDrug resistance and drug combination features of the human immunodeficiency virus inhibitor, BCH-10652 [(+/-)-2'-deoxy-3'-oxa-4'-thiocytidine, dOTC].Selection of resistance-conferring mutations in HIV-1 by the nucleoside reverse transcriptase inhibitors (+/-)dOTC and (+/-)dOTFC.A novel point mutation at position 156 of reverse transcriptase from feline immunodeficiency virus confers resistance to the combination of (-)-beta-2',3'-dideoxy-3'-thiacytidine and 3'-azido-3'-deoxythymidineHuman immunodeficiency virus replication and genotypic resistance in blood and lymph nodes after a year of potent antiretroviral therapyGenotypic changes in human immunodeficiency virus type 1 associated with loss of suppression of plasma viral RNA levels in subjects treated with ritonavir (Norvir) monotherapyDevelopment of an in vivo assay to identify structural determinants in murine leukemia virus reverse transcriptase important for fidelityWild-type and YMDD mutant murine leukemia virus reverse transcriptases are resistant to 2',3'-dideoxy-3'-thiacytidineHuman immunodeficiency virus drug resistance testing: state of the art in genotypic and phenotypic testing of antiretrovirals.Tribute to Mark WainbergThe Role of Nucleotide Excision by Reverse Transcriptase in HIV Drug Resistance.Genotypic testing for human immunodeficiency virus type 1 drug resistance.A rapid non-culture-based assay for clinical monitoring of phenotypic resistance of human immunodeficiency virus type 1 to lamivudine (3TC)The M184V mutation reduces the selective excision of zidovudine 5'-monophosphate (AZTMP) by the reverse transcriptase of human immunodeficiency virus type 1Differential susceptibility of retroviruses to nucleoside analogues.Heterogeneous clearance rates of long-lived lymphocytes infected with HIV: intrinsic stability predicts lifelong persistenceA novel genetic pathway of human immunodeficiency virus type 1 resistance to stavudine mediated by the K65R mutation.Generation of stable cell lines expressing Lamivudine-resistant hepatitis B virus for antiviral-compound screening.Analysis of mutations at position 184 in reverse transcriptase of human immunodeficiency virus type 1.Antiviral, metabolic, and pharmacokinetic properties of the isomeric dideoxynucleoside 4(S)-(6-amino-9H-purin-9-yl)tetrahydro-2(S)-furanmethanol.Generation of duck hepatitis B virus polymerase mutants through site-directed mutagenesis which demonstrate resistance to lamivudine [(--)-beta-L-2', 3'-dideoxy-3'-thiacytidine] in vitroGenotypic and phenotypic changes during culture of a multinucleoside-resistant human immunodeficiency virus type 1 strain in the presence and absence of additional reverse transcriptase inhibitors.Line probe assay for rapid detection of drug-selected mutations in the human immunodeficiency virus type 1 reverse transcriptase genePossible therapeutic vaccine strategy against human immunodeficiency virus escape from reverse transcriptase inhibitors studied in HLA-A2 transgenic miceMutations at codon 184 in simian immunodeficiency virus reverse transcriptase confer resistance to the (-) enantiomer of 2',3'-dideoxy-3'-thiacytidine
P2860
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P2860
High-level resistance to (-) enantiomeric 2'-deoxy-3'-thiacytidine in vitro is due to one amino acid substitution in the catalytic site of human immunodeficiency virus type 1 reverse transcriptase
description
1993 nî lūn-bûn
@nan
1993 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1993 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
name
High-level resistance to (-) e ...... s type 1 reverse transcriptase
@ast
High-level resistance to (-) e ...... s type 1 reverse transcriptase
@en
High-level resistance to (-) e ...... s type 1 reverse transcriptase
@nl
type
label
High-level resistance to (-) e ...... s type 1 reverse transcriptase
@ast
High-level resistance to (-) e ...... s type 1 reverse transcriptase
@en
High-level resistance to (-) e ...... s type 1 reverse transcriptase
@nl
prefLabel
High-level resistance to (-) e ...... s type 1 reverse transcriptase
@ast
High-level resistance to (-) e ...... s type 1 reverse transcriptase
@en
High-level resistance to (-) e ...... s type 1 reverse transcriptase
@nl
P2093
P2860
P356
P1476
High-level resistance to (-) e ...... s type 1 reverse transcriptase
@en
P2093
C A Boucher
J M Cameron
M A Wainberg
P Schipper
R Schuurman
P2860
P304
P356
10.1128/AAC.37.10.2231
P407
P577
1993-10-01T00:00:00Z