IFN regulatory factor 5 is required for disease development in the FcgammaRIIB-/-Yaa and FcgammaRIIB-/- mouse models of systemic lupus erythematosus - Wikidata - awgldk - TriplyDB

IFN regulatory factor 5 is required for disease development in the FcgammaRIIB-/-Yaa and FcgammaRIIB-/- mouse models of systemic lupus erythematosus

IFN regulatory factor 5 is required for disease development in the FcgammaRIIB-/-Yaa and FcgammaRIIB-/- mouse models of systemic lupus erythematosus

http://www.wikidata.org/entity/Q33804141

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Activation of interferon regulatory factor 5 by site specific phosphorylation Linking susceptibility genes and pathogenesis mechanisms using mouse models of systemic lupus erythematosus Role of type I interferons in the activation of autoreactive B cells IRF5 haplotypes demonstrate diverse serological associations which predict serum interferon alpha activity and explain the majority of the genetic association with systemic lupus erythematosus Brief Report: IRF5 systemic lupus erythematosus risk haplotype is associated with asymptomatic serologic autoimmunity and progression to clinical autoimmunity in mothers of children with neonatal lupus Type I interferon receptor deficiency prevents murine Sjogren's syndrome Distinct regulation of murine lupus susceptibility genes by the IRF5/Blimp-1 axis Spontaneous activation of RNA-sensing pathways in autoimmune disease.Contribution of IRF5 in B cells to the development of murine SLE-like disease through its transcriptional control of the IgG2a locus.Interferon regulatory factor-5 deficiency ameliorates disease severity in the MRL/lpr mouse model of lupus in the absence of a mutation in DOCK2.Nucleic acid sensing receptors in systemic lupus erythematosus: development of novel DNA- and/or RNA-like analogues for treating lupus.Gender-dependent expression of murine Irf5 gene: implications for sex bias in autoimmunity RNA-Seq for enrichment and analysis of IRF5 transcript expression in SLE.Interferon regulatory factors in human lupus pathogenesis IRF5 deficiency ameliorates lupus but promotes atherosclerosis and metabolic dysfunction in a mouse model of lupus-associated atherosclerosis Genetic susceptibility to systemic lupus erythematosus in the genomic era IRF4 deficiency abrogates lupus nephritis despite enhancing systemic cytokine production The PTPN22 allele encoding an R620W variant interferes with the removal of developing autoreactive B cells in humans Ifih1 gene dose effect reveals MDA5-mediated chronic type I IFN gene signature, viral resistance, and accelerated autoimmunity.Historical overview of immunological tolerance.Pleiotropic IFN-dependent and -independent effects of IRF5 on the pathogenesis of experimental lupus Unique contribution of IRF-5-Ikaros axis to the B-cell IgG2a response.Phenotype and function of B cells and dendritic cells from interferon regulatory factor 5-deficient mice with and without a mutation in DOCK2.Irf5-deficient mice are protected from pristane-induced lupus via increased Th2 cytokines and altered IgG class switching.Specific detection of interferon regulatory factor 5 (IRF5): A case of antibody inequality.Genetics of the type I interferon pathway in systemic lupus erythematosus.Regulatory and pathogenetic mechanisms of autoantibodies in SLE.Toll-like receptor driven B cell activation in the induction of systemic autoimmunity.New tools for classification and monitoring of autoimmune diseases Interferon regulatory factor 5 in the pathogenesis of systemic lupus erythematosus.Interferon regulatory factor 5 and autoimmune lupus.Epigenetics and the IRFs: a complex interplay in the control of immunity and autoimmunity.Genetics and pathogenesis of systemic lupus erythematosus and lupus nephritis.Genetic association and interaction between the IRF5 and TYK2 genes and systemic lupus erythematosus in the Han Chinese population.Understanding Human Autoimmunity and Autoinflammation Through Transcriptomics.Reactivity profiles of broadly neutralizing anti-HIV-1 antibodies are distinct from those of pathogenic autoantibodies.Overexpression of membrane-bound fas ligand (CD95L) exacerbates autoimmune disease and renal pathology in pristane-induced lupus.Interferon regulatory factor 5 is critical for the development of lupus in MRL/lpr mice.A meta-analysis of the association of IRF5 polymorphism with systemic lupus erythematosus.Lupus nephritis progression in FcγRIIB-/-yaa mice is associated with early development of glomerular electron dense deposits and loss of renal DNase I in severe disease.

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IFN regulatory factor 5 is required for disease development in the FcgammaRIIB-/-Yaa and FcgammaRIIB-/- mouse models of systemic lupus erythematosus

http://www.wikidata.org/entity/Q33804141

description

2009 nî lūn-bûn

@nan

2009 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2009 թվականի դեկտեմբերին հրատարակված գիտական հոդված

@hy

2009年の論文

@ja

2009年論文

@yue

2009年論文

@zh-hant

2009年論文

@zh-hk

2009年論文

@zh-mo

2009年論文

@zh-tw

2009年论文

@wuu

name

IFN regulatory factor 5 is req ...... f systemic lupus erythematosus

@ast

IFN regulatory factor 5 is req ...... f systemic lupus erythematosus

@en

type

label

IFN regulatory factor 5 is req ...... f systemic lupus erythematosus

@ast

IFN regulatory factor 5 is req ...... f systemic lupus erythematosus

@en

prefLabel

IFN regulatory factor 5 is req ...... f systemic lupus erythematosus

@ast

IFN regulatory factor 5 is req ...... f systemic lupus erythematosus

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JIMMUNOL.0901748

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Journal of Immunology

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IFN regulatory factor 5 is req ...... f systemic lupus erythematosus

@en

P2093

Amanda A Watkins

http://www.w3.org/2001/XMLSchema#string

Ann Marshak-Rothstein

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Chih Long Liu

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Christophe Richez

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Patricia Busto

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Paul J Utz

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Regina Cheung

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Rocco J Richards

http://www.w3.org/2001/XMLSchema#string

P2860

Functional role of type I and type II interferons in antiviral defense

Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci

Polymorphisms in the tyrosine kinase 2 and interferon regulatory factor 5 genes are associated with systemic lupus erythematosus

Multiple regulatory domains of IRF-5 control activation, cellular localization, and induction of chemokines that mediate recruitment of T lymphocytes

Rationale for interleukin-6 blockade in systemic lupus erythematosus

Significance analysis of microarrays applied to the ionizing radiation response

The IRF family, revisited

Virus-induced heterodimer formation between IRF-5 and IRF-7 modulates assembly of the IFNA enhanceosome in vivo and transcriptional activity of IFNA genes

Virus-specific activation of a novel interferon regulatory factor, IRF-5, results in the induction of distinct interferon alpha genes

A common haplotype of interferon regulatory factor 5 (IRF5) regulates splicing and expression and is associated with increased risk of systemic lupus erythematosus

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796-806

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scholarly article

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10.4049/JIMMUNOL.0901748

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2

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184

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Tamar R Aprahamian

Ramon G Bonegio

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2009-12-09T00:00:00Z

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40685291

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20007534

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2858062

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