Secreted amyloid β-proteins in a cell culture model include N-terminally extended peptides that impair synaptic plasticity - Wikidata - awgldk - TriplyDB

Secreted amyloid β-proteins in a cell culture model include N-terminally extended peptides that impair synaptic plasticity

Secreted amyloid β-proteins in a cell culture model include N-terminally extended peptides that impair synaptic plasticity

http://www.wikidata.org/entity/Q33805904

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P1343

The amyloid hypothesis of Alzheimer's disease at 25 years Dendritic and axonal mechanisms of Ca2+ elevation impair BDNF transport in Aβ oligomer-treated hippocampal neurons N-Terminal Extensions Retard Aβ42 Fibril Formation but Allow Cross-Seeding and Coaggregation with Aβ42 The Case for Abandoning Therapeutic Chelation of Copper Ions in Alzheimer's Disease p62 improves AD-like pathology by increasing autophagy η-Secretase processing of APP inhibits neuronal activity in the hippocampus.Lessons from a Rare Familial Dementia: Amyloid and Beyond.The aqueous phase of Alzheimer's disease brain contains assemblies built from ∼4 and ∼7 kDa Aβ species.New tricks from an old dog: Another synaptotoxic fragment from APP Soluble Aβ oligomers impair hippocampal LTP by disrupting glutamatergic/GABAergic balance.Inhibiting BACE1 to reverse synaptic dysfunctions in Alzheimer's disease.Environmental Enrichment Potently Prevents Microglia-Mediated Neuroinflammation by Human Amyloid β-Protein Oligomers Do anti-amyloid beta protein antibody cross reactivities confound Alzheimer disease research?Biometals and their therapeutic implications in Alzheimer's disease.Toxic oligomer species of amyloid-β in Alzheimer's disease, a timing issue.Non-canonical soluble amyloid-beta aggregates and plaque buffering: controversies and future directions for target discovery in Alzheimer's disease.A Greek Tragedy: The Growing Complexity of Alzheimer Amyloid Precursor Protein Proteolysis.Amyloid misfolding, aggregation, and the early onset of protein deposition diseases: insights from AFM experiments and computational analyses.Nanoplasmonic fiber tip probe detects significant reduction of intracellular Alzheimer's disease-related oligomers by curcumin.Protective effects of Dendrobium nobile Lindl. alkaloids on amyloid beta (25-35)-induced neuronal injury.Monomer-dependent secondary nucleation in amyloid formation.Alzheimer's disease-related amyloid-β induces synaptotoxicity in human iPS cell-derived neurons.Gleevec shifts APP processing from a β-cleavage to a nonamyloidogenic cleavage Soluble Gamma-secretase Modulators Attenuate Alzheimer's β-amyloid Pathology and Induce Conformational Changes in Presenilin 1.The Aggregation Paths and Products of Aβ42 Dimers Are Distinct from Those of the Aβ42 Monomer.Discrete pools of oligomeric amyloid-β track with spatial learning deficits in a mouse model of Alzheimer amyloidosis.Amyloid-β dimers in the absence of plaque pathology impair learning and synaptic plasticity.Human Brain-Derived Aβ Oligomers Bind to Synapses and Disrupt Synaptic Activity in a Manner That Requires APP.Amyloid Beta Peptides Block New Synapse Assembly by Nogo Receptor-Mediated Inhibition of T-Type Calcium Channels.Peripheral Interventions Enhancing Brain Glutamate Homeostasis Relieve Amyloid β- and TNFα- Mediated Synaptic Plasticity Disruption in the Rat Hippocampus.Improved Neuroprotection Provided by Drug Combination in Neurons Exposed to Cell-Derived Soluble Amyloid-β Peptide.Mechanisms that synergistically regulate η-secretase processing of APP and Aη-α protein levels: relevance to pathogenesis and treatment of Alzheimer's disease.The Amyloid-β Oligomer Hypothesis: Beginning of the Third Decade.Extracellular Forms of Aβ and Tau from iPSC Models of Alzheimer's Disease Disrupt Synaptic Plasticity.

P2860

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P1343

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P2860

Secreted amyloid β-proteins in a cell culture model include N-terminally extended peptides that impair synaptic plasticity

http://www.wikidata.org/entity/Q33805904

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2014 nî lūn-bûn

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2014 թուականի Յունիսին հրատարակուած գիտական յօդուած

@hyw

2014 թվականի հունիսին հրատարակված գիտական հոդված

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2014年の論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年论文

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Secreted amyloid β-proteins in ...... hat impair synaptic plasticity

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Secreted amyloid β-proteins in ...... hat impair synaptic plasticity

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P2093

Alfred T Welzel

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Beth L Ostaszewski

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Dennis J Selkoe

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Dominic M Walsh

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Donald E Walker

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Ganesh M Shankar

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Igor Klyubin

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John E Maggio

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Peter Seubert

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Shaomin Li

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P2860

Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

Soluble oligomers of amyloid Beta protein facilitate hippocampal long-term depression by disrupting neuronal glutamate uptake

Potent memapsin 2 (β-secretase) inhibitors: Design, synthesis, protein-ligand X-ray structure, and in vivo evaluation

Bapineuzumab captures the N-terminus of the Alzheimer's disease amyloid-beta peptide in a helical conformation

Crystal structure reveals conservation of amyloid-β conformation recognized by 3D6 following humanization to bapineuzumab

Mass Spectrometric Sequencing of Proteins from Silver-Stained Polyacrylamide Gels

Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo

A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of beta-amyloid

Evidence that production and release of amyloid beta-protein involves the endocytic pathway

In vitro peroxidase oxidation induces stable dimers of beta-amyloid (1-42) through dityrosine bridge formation

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3908-3921

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scholarly article

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10.1021/BI5003053

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24

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53

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Michael J Rowan

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2014-06-01T00:00:00Z

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262538988

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24840308

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