The human papillomavirus type 16 E6 gene alone is sufficient to induce carcinomas in transgenic animals. - Wikidata - awgldk - TriplyDB

The human papillomavirus type 16 E6 gene alone is sufficient to induce carcinomas in transgenic animals.

The human papillomavirus type 16 E6 gene alone is sufficient to induce carcinomas in transgenic animals.

http://www.wikidata.org/entity/Q33815722

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Cancer is a preventable disease that requires major lifestyle changes Multi-PDZ domain protein MUPP1 is a cellular target for both adenovirus E4-ORF1 and high-risk papillomavirus type 18 E6 oncoproteins Human scribble (Vartul) is targeted for ubiquitin-mediated degradation by the high-risk papillomavirus E6 proteins and the E6AP ubiquitin-protein ligase Immunocompromised and immunocompetent mouse models for head and neck squamous cell carcinoma Regulation of the Wnt/β-Catenin Signaling Pathway by Human Papillomavirus E6 and E7 Oncoproteins Beta-catenin accelerates human papilloma virus type-16 mediated cervical carcinogenesis in transgenic mice Role of Ultraviolet Radiation in Papillomavirus-Induced Disease Requirement of PDZ-containing proteins for cell cycle regulation and differentiation in the mouse lens epithelium Model-Based Tumor Growth Dynamics and Therapy Response in a Mouse Model of De Novo Carcinogenesis Papillomavirus E6 oncoproteins.Surveillance of human papilloma virus using reference laboratory data for the purpose of evaluating vaccine impact.HPV E6, E6AP and cervical cancer.Gene expression profile of cervical and skin tissues from human papillomavirus type 16 E6 transgenic mice.A role for HPV16 E5 in cervical carcinogenesis.Human papillomavirus 16 E5 oncogene contributes to two stages of skin carcinogenesis Human papillomavirus E7 oncoprotein overrides the tumor suppressor activity of p21Cip1 in cervical carcinogenesis.HUMAN PAPILLOMAVIRUS ASSOCIATION WITH HEAD AND NECK CANCERS: UNDERSTANDING VIRUS BIOLOGY AND USING IT IN THE DEVELOPMENT OF CANCER DIAGNOSTICS Human papillomavirus type 16 E6 induces self-ubiquitination of the E6AP ubiquitin-protein ligase Role of Rb-dependent and Rb-independent functions of papillomavirus E7 oncogene in head and neck cancer.The human papillomavirus E6 oncogene dysregulates the cell cycle and contributes to cervical carcinogenesis through two independent activities.p53 Loss synergizes with estrogen and papillomaviral oncogenes to induce cervical and breast cancers.Estrogen contributes to the onset, persistence, and malignant progression of cervical cancer in a human papillomavirus-transgenic mouse model.GRIM-19 disrupts E6/E6AP complex to rescue p53 and induce apoptosis in cervical cancers.Human papillomavirus type 16 E1circumflexE4 contributes to multiple facets of the papillomavirus life cycle.The role of human papillomavirus 16 E6 in anchorage-independent and invasive growth of mouse tonsil epithelium.Human papillomavirus type 16 E6 amino acid 83 variants enhance E6-mediated MAPK signaling and differentially regulate tumorigenesis by notch signaling and oncogenic Ras.Human papillomavirus 16 E6 variants differ in their dysregulation of human keratinocyte differentiation and apoptosis.Biology of human papillomaviruses.A mutant of human papillomavirus type 16 E6 deficient in binding alpha-helix partners displays reduced oncogenic potential in vivo.A mouse model for human anal cancer Overexpression of ANXA1 in penile carcinomas positive for high-risk HPVs.Rapamycin inhibits anal carcinogenesis in two preclinical animal models.Quantitative role of the human papillomavirus type 16 E5 gene during the productive stage of the viral life cycle.High incidence of HPV-associated head and neck cancers in FA deficient mice is associated with E7's induction of DNA damage through its inactivation of pocket proteins The PDZ ligand domain of the human papillomavirus type 16 E6 protein is required for E6's induction of epithelial hyperplasia in vivo.Identification of biomarkers that distinguish human papillomavirus (HPV)-positive versus HPV-negative head and neck cancers in a mouse model.Small molecule inhibitors of human papillomavirus protein - protein interactions.Tumorigenic activity of merkel cell polyomavirus T antigens expressed in the stratified epithelium of mice.Gene expression profiles are altered in human papillomavirus-16 E6 D25E-expressing cell lines.Modulation of apoptosis by human papillomavirus (HPV) oncoproteins.

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P2860

The human papillomavirus type 16 E6 gene alone is sufficient to induce carcinomas in transgenic animals.

http://www.wikidata.org/entity/Q33815722

description

1999 nî lūn-bûn

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1999 թուականի Յուլիսին հրատարակուած գիտական յօդուած

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1999 թվականի հուլիսին հրատարակված գիտական հոդված

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1999年の論文

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The human papillomavirus type ...... cinomas in transgenic animals.

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The human papillomavirus type ...... cinomas in transgenic animals.

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P2860

Binding of human virus oncoproteins to hDlg/SAP97, a mammalian homolog of the Drosophila discs large tumor suppressor protein

The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53

Interaction of papillomavirus E6 oncoproteins with a putative calcium-binding protein

Homologous sequences in adenovirus E1A and human papillomavirus E7 proteins mediate interaction with the same set of cellular proteins

The E6 oncoproteins of high-risk papillomaviruses bind to a novel putative GAP protein, E6TP1, and target it for degradation

Binding of high-risk human papillomavirus E6 oncoproteins to the human homologue of the Drosophila discs large tumor suppressor protein

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53

The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product

Nonradioactive RNA in situ hybridization detection of human papillomavirus 16-E7 transcripts in squamous cell carcinomas of the uterine cervix using confocal laser scan microscopy.

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