The critical role of AKT2 in hepatic steatosis induced by PTEN loss.
about
Akt stimulates hepatic SREBP1c and lipogenesis through parallel mTORC1-dependent and independent pathwaysRole of PI3K, mTOR and Akt2 signalling in hepatic tumorigenesis via the control of PKM2 expressionShort term feeding of a high fat diet exerts an additive effect on hepatocellular damage and steatosis in liver-specific PTEN knockout miceTuberous sclerosis complex-1 deficiency attenuates diet-induced hepatic lipid accumulation.Liver clock protein BMAL1 promotes de novo lipogenesis through insulin-mTORC2-AKT signalingTargeting Forkhead box O1 from the concept to metabolic diseases: lessons from mouse models.Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) inhibition by 4-hydroxynonenal leads to increased Akt activation in hepatocytes.Liver-specific inducible nitric-oxide synthase expression is sufficient to cause hepatic insulin resistance and mild hyperglycemia in mice.Maf1 is a novel target of PTEN and PI3K signaling that negatively regulates oncogenesis and lipid metabolismLivers with constitutive mTORC1 activity resist steatosis independent of feedback suppression of Akt.PPARγ contributes to PKM2 and HK2 expression in fatty liverMathematical Modelling of Molecular Pathways Enabling Tumour Cell Invasion and Migration.Targeting the glucose-regulated protein-78 abrogates Pten-null driven AKT activation and endometrioid tumorigenesis.Liver-Specific Deletion of Phosphatase and Tensin Homolog Deleted on Chromosome 10 Significantly Ameliorates Chronic EtOH-Induced Increases in Hepatocellular DamageHepatic proteomic analysis revealed altered metabolic pathways in insulin resistant Akt1(+/-)/Akt2(-/-) miceSaturated Fatty Acid-induced cytotoxicity in liver cells does not involve phosphatase and tensin homologue deleted on chromosome 10.Increased carbonylation of the lipid phosphatase PTEN contributes to Akt2 activation in a murine model of early alcohol-induced steatosisSystematic review: association of polycystic ovary syndrome with metabolic syndrome and non-alcoholic fatty liver disease.PI3K/AKT, MAPK and AMPK signalling: protein kinases in glucose homeostasis.Molecular mechanisms of oncogene-induced inflammation and inflammation-sustained oncogene activation in gastrointestinal tumors: an under-appreciated symbiotic relationship.Wnt/β-catenin activation and macrophage induction during liver cancer development following steatosis.Postprandial hepatic lipid metabolism requires signaling through Akt2 independent of the transcription factors FoxA2, FoxO1, and SREBP1cAkt2-Dependent Phosphorylation of Radixin in Regulation of Mrp-2 Trafficking in WIF-B Cells.Maf1, A New PTEN Target Linking RNA and Lipid Metabolism.Hepatic Expression of Adenovirus 36 E4ORF1 Improves Glycemic Control and Promotes Glucose Metabolism Through AKT Activation.Unraveling the Regulation of Hepatic Metabolism by Insulin.The kielin/chordin-like protein KCP attenuates nonalcoholic fatty liver disease in mice.Down-regulation of phosphatase and tensin homolog by hepatitis C virus core 3a in hepatocytes triggers the formation of large lipid droplets.Expansion of hepatic tumor progenitor cells in Pten-null mice requires liver injury and is reversed by loss of AKT2.Constitutive Activation of AKT2 in Humans Leads to Hypoglycemia Without Fatty Liver or Metabolic Dyslipidemia.Loss of Akt1 in mice increases energy expenditure and protects against diet-induced obesity.PI3K/AKT signaling regulates bioenergetics in immortalized hepatocytes.Activation of hepatic stellate cell in Pten null liver injury model.Reduced hepatic lipid content in Pten-haplodeficient mice because of enhanced AKT2/PKBβ activation in skeletal muscle.PTEN in liver diseases and cancerActivated mutant forms of PIK3CA cooperate with RasV12 or c-Met to induce liver tumour formation in mice via AKT2/mTORC1 cascade.Adaptive basal phosphorylation of eIF2α is responsible for resistance to cellular stress-induced cell death in Pten-null hepatocytes.Increase of fatty acid oxidation and VLDL assembly and secretion overexpression of PTEN in cultured hepatocytes of newborn calf.Loss of Pten synergizes with c-Met to promote hepatocellular carcinoma development via mTORC2 pathway.Hippo-mediated suppression of IRS2/AKT signaling prevents hepatic steatosis and liver cancer.
P2860
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P2860
The critical role of AKT2 in hepatic steatosis induced by PTEN loss.
description
2010 nî lūn-bûn
@nan
2010 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի մարտին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
The critical role of AKT2 in hepatic steatosis induced by PTEN loss.
@ast
The critical role of AKT2 in hepatic steatosis induced by PTEN loss.
@en
type
label
The critical role of AKT2 in hepatic steatosis induced by PTEN loss.
@ast
The critical role of AKT2 in hepatic steatosis induced by PTEN loss.
@en
prefLabel
The critical role of AKT2 in hepatic steatosis induced by PTEN loss.
@ast
The critical role of AKT2 in hepatic steatosis induced by PTEN loss.
@en
P2093
P2860
P1476
The critical role of AKT2 in hepatic steatosis induced by PTEN loss.
@en
P2093
Bangyan L Stiles
Gary Kanel
Morris J Birnbaum
Vivian Galicia
Xiaogang Hou
P2860
P304
P356
10.2353/AJPATH.2010.090931
P407
P577
2010-03-26T00:00:00Z