Induction of intrahepatic cholangiocellular carcinoma by liver-specific disruption of Smad4 and Pten in mice. - Wikidata - awgldk - TriplyDB

Induction of intrahepatic cholangiocellular carcinoma by liver-specific disruption of Smad4 and Pten in mice.

Induction of intrahepatic cholangiocellular carcinoma by liver-specific disruption of Smad4 and Pten in mice.

http://www.wikidata.org/entity/Q34661807

about

Screening of potential biomarkers for cholangiocarcinoma by integrated analysis of microarray data sets.Hepatic FcRn regulates albumin homeostasis and susceptibility to liver injury Genetic and molecular abnormalities in cholangiocarcinogenesis.Smad4-mediated TGF-beta signaling in tumorigenesis.Nrf2 enhances cholangiocyte expansion in Pten-deficient livers Signaling via Alk5 controls the ontogeny of lung Clara cells.Antitumor activity of the combination of an HSP90 inhibitor and a PI3K/mTOR dual inhibitor against cholangiocarcinoma Mutational profiling reveals PIK3CA mutations in gallbladder carcinoma.The critical role of AKT2 in hepatic steatosis induced by PTEN loss.Genome-wide expression patterns associated with oncogenesis and sarcomatous transdifferentation of cholangiocarcinoma.Extracellular matrix dynamics in hepatocarcinogenesis: a comparative proteomics study of PDGFC transgenic and Pten null mouse models.Nf2/Merlin controls progenitor homeostasis and tumorigenesis in the liver The Merlin/NF2 tumor suppressor functions through the YAP oncoprotein to regulate tissue homeostasis in mammals.Prostate apoptosis response-4 is expressed in normal cholangiocytes, is down-regulated in human cholangiocarcinoma, and promotes apoptosis of neoplastic cholangiocytes when induced pharmacologically Anterior visceral endoderm SMAD4 signaling specifies anterior embryonic patterning and head induction in mice.Functional screening for miRNAs targeting Smad4 identified miR-199a as a negative regulator of TGF-β signalling pathway.CRISPR/Cas9 somatic multiplex-mutagenesis for high-throughput functional cancer genomics in mice.Pathogenesis, diagnosis, and management of cholangiocarcinoma Microsomal prostaglandin E synthase-1 inhibits PTEN and promotes experimental cholangiocarcinogenesis and tumor progression.TGF-β signaling alters the pattern of liver tumorigenesis induced by Pten inactivation.Maf1 is a novel target of PTEN and PI3K signaling that negatively regulates oncogenesis and lipid metabolism SMAD4 exerts a tumor-promoting role in hepatocellular carcinoma.Fate tracing of mature hepatocytes in mouse liver homeostasis and regeneration Two sides of the story? Smad4 loss in pancreatic cancer versus head-and-neck cancer Interleukin-6-driven progranulin expression increases cholangiocarcinoma growth by an Akt-dependent mechanism Anti-Tumor Effects of Second Generation β-Hydroxylase Inhibitors on Cholangiocarcinoma Development and Progression.Smad4 loss promotes lung cancer formation but increases sensitivity to DNA topoisomerase inhibitors.Precise let-7 expression levels balance organ regeneration against tumor suppression The novel growth factor, progranulin, stimulates mouse cholangiocyte proliferation via sirtuin-1-mediated inactivation of FOXO1.Primarily screening and analyzing ESTs differentially expressed in rats' primary liver cancer Mutations of TGFbeta signaling molecules in human disease.The challenge of cholangiocarcinoma: dissecting the molecular mechanisms of an insidious cancer.Akt and mTORC1 have different roles during liver tumorigenesis in mice.Cholangiocarcinoma: advances in pathogenesis, diagnosis, and treatment.Liver carcinogenesis: rodent models of hepatocarcinoma and cholangiocarcinoma.Portrait of PTEN: messages from mutant mice.Intrahepatic cholangiocarcinoma progression: prognostic factors and basic mechanisms.Mouse model of intrahepatic cholangiocarcinoma validates FIG-ROS as a potent fusion oncogene and therapeutic target.Postnatal ablation of osteoblast Smad4 enhances proliferative responses to canonical Wnt signaling through interactions with β-catenin.Comparative analysis of the liver and plasma proteomes as a novel and powerful strategy for hepatocellular carcinoma biomarker discovery.

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P2860

Induction of intrahepatic cholangiocellular carcinoma by liver-specific disruption of Smad4 and Pten in mice.

http://www.wikidata.org/entity/Q34661807

description

2006 nî lūn-bûn

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2006 թուականի Յունիսին հրատարակուած գիտական յօդուած

@hyw

2006 թվականի հունիսին հրատարակված գիտական հոդված

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2006年の論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年论文

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name

Induction of intrahepatic chol ...... ion of Smad4 and Pten in mice.

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Induction of intrahepatic chol ...... ion of Smad4 and Pten in mice.

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Induction of intrahepatic chol ...... ion of Smad4 and Pten in mice.

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type

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Induction of intrahepatic chol ...... ion of Smad4 and Pten in mice.

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Induction of intrahepatic chol ...... ion of Smad4 and Pten in mice.

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Induction of intrahepatic chol ...... ion of Smad4 and Pten in mice.

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prefLabel

Induction of intrahepatic chol ...... ion of Smad4 and Pten in mice.

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Induction of intrahepatic chol ...... ion of Smad4 and Pten in mice.

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Induction of intrahepatic chol ...... ion of Smad4 and Pten in mice.

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Journal of Clinical Investigation

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Induction of intrahepatic chol ...... ion of Smad4 and Pten in mice.

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P2093

Bangyan Stiles

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Bin Gao

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Chu-Xia Deng

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Cuiling Li

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Cuiying Xiao

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Hong Wu

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Michael S Torbenson

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Nobuya Ohara

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Rui-Hong Wang

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Shogo Kobayashi

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P2860

TGF-beta signal transduction

TEP1, encoded by a candidate tumor suppressor locus, is a novel protein tyrosine phosphatase regulated by transforming growth factor beta

The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

Generalized lacZ expression with the ROSA26 Cre reporter strain

TGF-beta signalling from cell membrane to nucleus through SMAD proteins

Hepatocyte growth factor induces Wnt-independent nuclear translocation of beta-catenin after Met-beta-catenin dissociation in hepatocytes

The biology and clinical relevance of the PTEN tumor suppressor pathway

Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization

Gastric and duodenal polyps in Smad4 (Dpc4) knockout mice

The tumor suppressor gene Smad4/Dpc4 is required for gastrulation and later for anterior development of the mouse embryo

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1843-1852

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10.1172/JCI27282

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7

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116

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Gregory J Gores

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