Coordinate regulation of the mother centriole component nlp by nek2 and plk1 protein kinases.
about
Centrosome-associated regulators of the G(2)/M checkpoint as targets for cancer therapyAlternative splicing controls nuclear translocation of the cell cycle-regulated Nek2 kinaseMitotic regulation by NIMA-related kinasesPlk1-dependent recruitment of gamma-tubulin complexes to mitotic centrosomes involves multiple PCM componentsRequirement of hCenexin for proper mitotic functions of polo-like kinase 1 at the centrosomesMutations in Drosophila Greatwall/Scant reveal its roles in mitosis and meiosis and interdependence with Polo kinaseStructure and regulation of the human Nek2 centrosomal kinaseAminopyrazine Inhibitors Binding to an Unusual Inactive Conformation of the Mitotic Kinase Nek2: SAR and Structural CharacterizationDesign of Potent and Selective Hybrid Inhibitors of the Mitotic Kinase Nek2: Structure–Activity Relationship, Structural Biology, and Cellular ActivityNIMA-related kinase 2 regulates hepatocellular carcinoma cell growth and proliferationCentrosomal Nlp is an oncogenic protein that is gene-amplified in human tumors and causes spontaneous tumorigenesis in transgenic mice.Liver kinase B1 regulates the centrosome via PLK1.Centrobin/NIP2 is a microtubule stabilizer whose activity is enhanced by PLK1 phosphorylation during mitosisAurora B interaction of centrosomal Nlp regulates cytokinesis.Cell cycle-dependent expression of centrosomal ninein-like protein in human cells is regulated by the anaphase-promoting complex.The role of centrosomal Nlp in the control of mitotic progression and tumourigenesis.Role of NEK2A in human cancer and its therapeutic potentials.Proteomic screen defines the Polo-box domain interactome and identifies Rock2 as a Plk1 substrate.The mitotic spindle protein SPAG5/Astrin connects to the Usher protein network postmitoticallyTargeting NEK2 as a promising therapeutic approach for cancer treatment.Structural centrosome aberrations favor proliferation by abrogating microtubule-dependent tissue integrity of breast epithelial mammospheresTransient phosphorylation of tumor associated microtubule associated protein (TMAP)/cytoskeleton associated protein 2 (CKAP2) at Thr-596 during early phases of mitosisBRCA1 interaction of centrosomal protein Nlp is required for successful mitotic progression.Nek2A/SuFu feedback loop regulates Gli-mediated Hedgehog signaling pathway.Preclinical activity of MBM-5 in gastrointestinal cancer by inhibiting NEK2 kinase activity.Nek2 and Plk4: prognostic markers, drivers of breast tumorigenesis and drug resistance.Systematic analysis of the Plk-mediated phosphoregulation in eukaryotes.Structure, function, and evolution of plant NIMA-related kinases: implication for phosphorylation-dependent microtubule regulation.Centrosomes in spindle organization and chromosome segregation: a mechanistic view.Polo-like kinase 1 inhibition kills glioblastoma multiforme brain tumor cells in part through loss of SOX2 and delays tumor progression in mice.Plk1-mediated phosphorylation of UAP56 regulates the stability of UAP56.The Nek6 and Nek7 protein kinases are required for robust mitotic spindle formation and cytokinesis.Usher syndrome and Leber congenital amaurosis are molecularly linked via a novel isoform of the centrosomal ninein-like protein.Overexpression of the Nek2 kinase in colorectal cancer correlates with beta-catenin relocalization and shortened cancer-specific survival.Kizuna takes pole position.
P2860
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P2860
Coordinate regulation of the mother centriole component nlp by nek2 and plk1 protein kinases.
description
2005 nî lūn-bûn
@nan
2005 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Coordinate regulation of the m ...... nek2 and plk1 protein kinases.
@ast
Coordinate regulation of the m ...... nek2 and plk1 protein kinases.
@en
type
label
Coordinate regulation of the m ...... nek2 and plk1 protein kinases.
@ast
Coordinate regulation of the m ...... nek2 and plk1 protein kinases.
@en
prefLabel
Coordinate regulation of the m ...... nek2 and plk1 protein kinases.
@ast
Coordinate regulation of the m ...... nek2 and plk1 protein kinases.
@en
P2093
P2860
P1476
Coordinate regulation of the m ...... nek2 and plk1 protein kinases.
@en
P2093
Andrew M Fry
Joanne E Baxter
Joelle Blot
Joseph Rapley
Martina Casenghi
Samantha L Wattam
P2860
P304
P356
10.1128/MCB.25.4.1309-1324.2005
P407
P577
2005-02-01T00:00:00Z