Polo-like kinase 1 inhibition kills glioblastoma multiforme brain tumor cells in part through loss of SOX2 and delays tumor progression in mice.
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A high-content small molecule screen identifies sensitivity of glioblastoma stem cells to inhibition of polo-like kinase 1PLK1, A Potential Target for Cancer TherapyAsymmetric cell division of stem and progenitor cells during homeostasis and cancerRecapitulation of tumor heterogeneity and molecular signatures in a 3D brain cancer model with decreased sensitivity to histone deacetylase inhibitionThe evolving landscape of glioblastoma stem cells.Sox2 promotes malignancy in glioblastoma by regulating plasticity and astrocytic differentiationGlioma-propagating cells as an in vitro screening platform: PLK1 as a case study.ASYMMETRIC CELL DIVISION: IMPLICATIONS FOR GLIOMA DEVELOPMENT AND TREATMENT.Overcoming resistance to Sonic Hedgehog inhibition by targeting p90 ribosomal S6 kinase in pediatric medulloblastoma.By promoting cell differentiation, miR-100 sensitizes basal-like breast cancer stem cells to hormonal therapy.Mechanism of action and therapeutic efficacy of Aurora kinase B inhibition in MYC overexpressing medulloblastoma.Therapeutic targeting of polo-like kinase 1 using RNA-interfering nanoparticles (iNOPs) for the treatment of non-small cell lung cancer.Polo-like Kinase 1 as a potential therapeutic target in Diffuse Intrinsic Pontine GliomaSox2 enhances the tumorigenicity and chemoresistance of cancer stem-like cells derived from gastric cancerFOXC2 regulates the G2/M transition of stem cell-rich breast cancer cells and sensitizes them to PLK1 inhibition.Identification of key genes in glioblastoma-associated stromal cells using bioinformatics analysis.Inhibition of polo-like kinase 1 in glioblastoma multiforme induces mitotic catastrophe and enhances radiosensitisationTherapeutic relevance of the protein phosphatase 2A in cancer.Battle of the eternal rivals: restoring functional p53 and inhibiting Polo-like kinase 1 as cancer therapy.Concise reviews: cancer stem cells: from concept to cure.SOX2 immunity and tissue resident memory in children and young adults with glioma.Differential sensitivity of Glioma stem cells to Aurora kinase A inhibitors: implications for stem cell mitosis and centrosome dynamics.Polo-like kinase 1 inhibition causes decreased proliferation by cell cycle arrest, leading to cell death in glioblastoma.FoxG1 interacts with Bmi1 to regulate self-renewal and tumorigenicity of medulloblastoma stem cells.Disulfiram, a drug widely used to control alcoholism, suppresses the self-renewal of glioblastoma and over-rides resistance to temozolomide.Informed walks: whispering hints to gene hunters inside networks' jungleRegulation of cAMP and GSK3 signaling pathways contributes to the neuronal conversion of glioma.Targeting Polo-like kinase 1 in SMARCB1 deleted atypical teratoid rhabdoid tumor.Endogenous GABAA receptor activity suppresses glioma growth.A novel stem cell culture model of recurrent glioblastoma.Polo-like kinase 1 is overexpressed in renal cancer and participates in the proliferation and invasion of renal cancer cells.Targetable BET proteins- and E2F1-dependent transcriptional program maintains the malignancy of glioblastoma.Network integration of multi-tumour omics data suggests novel targeting strategiesPLK1 inhibitor facilitates the suppressing effect of temozolomide on human brain glioma stem cells
P2860
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P2860
Polo-like kinase 1 inhibition kills glioblastoma multiforme brain tumor cells in part through loss of SOX2 and delays tumor progression in mice.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
2012年學術文章
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2012年學術文章
@zh-hant
name
Polo-like kinase 1 inhibition ...... ays tumor progression in mice.
@en
Polo-like kinase 1 inhibition ...... ays tumor progression in mice.
@nl
type
label
Polo-like kinase 1 inhibition ...... ays tumor progression in mice.
@en
Polo-like kinase 1 inhibition ...... ays tumor progression in mice.
@nl
prefLabel
Polo-like kinase 1 inhibition ...... ays tumor progression in mice.
@en
Polo-like kinase 1 inhibition ...... ays tumor progression in mice.
@nl
P2093
P2860
P356
P1433
P1476
Polo-like kinase 1 inhibition ...... lays tumor progression in mice
@en
P2093
Aarthi Jayanthan
Abbas Fotovati
Aru Narendran
Chitra Venugopal
Chris Jones
Hiroaki Wakimoto
James Chen
Joanna Triscott
John M Kerr
P2860
P304
P356
10.1002/STEM.1081
P577
2012-06-01T00:00:00Z