Mutations in the DG loop of adenovirus type 5 fiber knob protein abolish high-affinity binding to its cellular receptor CAR.
about
Adenovirus serotype 30 fiber does not mediate transduction via the coxsackie-adenovirus receptor.Oncolytic adenovirus-mediated therapy for prostate cancerCAR-associated vesicular transport of an adenovirus in motor neuron axonsDevelopment of a generic adenovirus delivery system based on structure-guided design of bispecific trimeric DARPin adaptersVirotherapy: cancer gene therapy at last?CAR regulates epithelial cell junction stability through control of E-cadherin traffickingMechanism of ad5 vaccine immunity and toxicity: fiber shaft targeting of dendritic cells.Protein crystals in Adenovirus type 5-infected cells: requirements for intranuclear crystallogenesis, structural and functional analysisEctodomain of coxsackievirus and adenovirus receptor genetically fused to epidermal growth factor mediates adenovirus targeting to epidermal growth factor receptor-positive cells.Mechanistic aspects of adenovirus serotype 2 inactivation with free chlorineAdenovirus type 5 viral particles pseudotyped with mutagenized fiber proteins show diminished infectivity of coxsackie B-adenovirus receptor-bearing cells.CAR modulates E-cadherin dynamics in the presence of adenovirus type 5.Development of a targeted gene vector platform based on simian adenovirus serotype 24.Reduction of natural adenovirus tropism to mouse liver by fiber-shaft exchange in combination with both CAR- and alphav integrin-binding ablation.Engineering of adenovirus vectors containing heterologous peptide sequences in the C terminus of capsid protein IX.Subgroup B and F fiber chimeras eliminate normal adenovirus type 5 vector transduction in vitro and in vivo.Reduction of natural adenovirus tropism to the liver by both ablation of fiber-coxsackievirus and adenovirus receptor interaction and use of replaceable short fiber.Differential immunogenicity between HAdV-5 and chimpanzee adenovirus vector ChAdOx1 is independent of fiber and penton RGD loop sequences in miceTNFα promotes CAR-dependent migration of leukocytes across epithelial monolayers.Targeting of adenovirus serotype 5 pseudotyped with short fiber from serotype 41 to c-erbB2-positive cells using bispecific single-chain diabody.Dependence of adenovirus infectivity on length of the fiber shaft domain.Identification of contact residues and definition of the CAR-binding site of adenovirus type 5 fiber protein.Adenovirus type 9 fiber knob binds to the coxsackie B virus-adenovirus receptor (CAR) with lower affinity than fiber knobs of other CAR-binding adenovirus serotypesGenetic retargeting of adenovirus: novel strategy employing "deknobbing" of the fiber.Activation of p38 and ERK signaling during adenovirus vector cell entry lead to expression of the C-X-C chemokine IP-10.Targeting adenoviral vectors by using the extracellular domain of the coxsackie-adenovirus receptor: improved potency via trimerization.Efficient and selective gene transfer into primary human brain tumors by using single-chain antibody-targeted adenoviral vectors with native tropism abolished.Adenovirus binding to the coxsackievirus and adenovirus receptor or integrins is not required to elicit brain inflammation but is necessary to transduce specific neural cell types.Crystal structure of species D adenovirus fiber knobs and their sialic acid binding sites.The Arg279Gln [corrected] substitution in the adenovirus type 11p (Ad11p) fiber knob abolishes EDTA-resistant binding to A549 and CHO-CD46 cells, converting the phenotype to that of Ad7p.Designer Oncolytic Adenovirus: Coming of Age.
P2860
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P2860
Mutations in the DG loop of adenovirus type 5 fiber knob protein abolish high-affinity binding to its cellular receptor CAR.
description
1999 nî lūn-bûn
@nan
1999 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Mutations in the DG loop of ad ...... to its cellular receptor CAR.
@ast
Mutations in the DG loop of ad ...... to its cellular receptor CAR.
@en
type
label
Mutations in the DG loop of ad ...... to its cellular receptor CAR.
@ast
Mutations in the DG loop of ad ...... to its cellular receptor CAR.
@en
prefLabel
Mutations in the DG loop of ad ...... to its cellular receptor CAR.
@ast
Mutations in the DG loop of ad ...... to its cellular receptor CAR.
@en
P2093
P2860
P1433
P1476
Mutations in the DG loop of ad ...... to its cellular receptor CAR.
@en
P2093
A J Beavil
B J Sutton
P W Roelvink
T J Wickham
P2860
P304
P577
1999-11-01T00:00:00Z