Chk1 and Cds1: linchpins of the DNA damage and replication checkpoint pathways.
about
Chk2 regulates irradiation-induced, p53-mediated apoptosis in DrosophilaBinding of cyclin-dependent kinases to ORC and Cdc6p regulates the chromosome replication cycleFamilial breast cancer and the hCHK2 1100delC mutation: assessing cancer riskDNA Damage Signalling and Repair Inhibitors: The Long-Sought-After Achilles' Heel of CancerGenotoxic anti-cancer agents and their relationship to DNA damage, mitosis, and checkpoint adaptation in proliferating cancer cellsSeparate roles for the DNA damage checkpoint protein kinases in stabilizing DNA replication forks.Pds1 phosphorylation in response to DNA damage is essential for its DNA damage checkpoint functionRegulation of replication timing in fission yeast.The Schizosaccharomyces pombe checkpoint kinases Chk1 and Cds1 are important for cell survival in response to cisplatinXenopus Cds1 is regulated by DNA-dependent protein kinase and ATR during the cell cycle checkpoint response to double-stranded DNA endsChk1, but not Chk2, inhibits Cdc25 phosphatases by a novel common mechanism.The nuclear kinase Lsk1p positively regulates the septation initiation network and promotes the successful completion of cytokinesis in response to perturbation of the actomyosin ring in Schizosaccharomyces pombe.The fission yeast DNA structure checkpoint protein Rad26ATRIP/LCD1/UVSD accumulates in the cytoplasm following microtubule destabilizationRad9 modulates the P21WAF1 pathway by direct association with p53.Phase I study of 17-allylamino-17 demethoxygeldanamycin, gemcitabine and/or cisplatin in patients with refractory solid tumorsNovel positive feedback loop between Cdk1 and Chk1 in the nucleus during G2/M transition.Safeguarding entry into mitosis: the antephase checkpoint.Fission yeast Rad17 associates with chromatin in response to aberrant genomic structuresCritical functions of Rpa3/Ssb3 in S-phase DNA damage responses in fission yeast.Schizosaccharomyces pombe Swi1, Swi3, and Hsk1 are components of a novel S-phase response pathway to alkylation damage.p53 C-terminal phosphorylation by CHK1 and CHK2 participates in the regulation of DNA-damage-induced C-terminal acetylation.A single unpaired and transcriptionally silenced X chromosome locally precludes checkpoint signaling in the Caenorhabditis elegans germ lineMre11 nuclease activity and Ctp1 regulate Chk1 activation by Rad3ATR and Tel1ATM checkpoint kinases at double-strand breaks.Systematic deletion analysis of fission yeast protein kinases.Phosphorylation of the MBF repressor Yox1p by the DNA replication checkpoint keeps the G1/S cell-cycle transcriptional program active.The fission yeast Rad32(Mre11)-Rad50-Nbs1 complex acts both upstream and downstream of checkpoint signaling in the S-phase DNA damage checkpointSUMO-targeted ubiquitin ligase, Rad60, and Nse2 SUMO ligase suppress spontaneous Top1-mediated DNA damage and genome instability.Serine-345 is required for Rad3-dependent phosphorylation and function of checkpoint kinase Chk1 in fission yeast.Fission yeast F-box protein Pof3 is required for genome integrity and telomere function.Roles of the mitotic inhibitors Wee1 and Mik1 in the G(2) DNA damage and replication checkpoints.A single unbranched S-phase DNA damage and replication fork blockage checkpoint pathway.mcl1+, the Schizosaccharomyces pombe homologue of CTF4, is important for chromosome replication, cohesion, and segregation.A genetic screen for replication initiation defective (rid) mutants in Schizosaccharomyces pombeHistone chaperone Asf1 plays an essential role in maintaining genomic stability in fission yeastAutorepression of rfx1 gene expression: functional conservation from yeast to humans in response to DNA replication arrest.De novo assembly and characterization of bark transcriptome using Illumina sequencing and development of EST-SSR markers in rubber tree (Hevea brasiliensis Muell. Arg.).Influence of cell cycle checkpoints and p53 function on the toxicity of temozolomide in human pancreatic cancer cells.Triggering the all-or-nothing switch into mitosis.The MluI cell cycle box (MCB) motifs, but not damage-responsive elements (DREs), are responsible for the transcriptional induction of the rhp51+ gene in response to DNA replication stress.Cryptotanshinone has diverse effects on cell cycle events in melanoma cell lines with different metastatic capacity
P2860
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P2860
Chk1 and Cds1: linchpins of the DNA damage and replication checkpoint pathways.
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2000 nî lūn-bûn
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2000 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
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2000 թվականի նոյեմբերին հրատարակված գիտական հոդված
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2000年の論文
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2000年論文
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2000年論文
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2000年論文
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2000年論文
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2000年論文
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2000年论文
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name
Chk1 and Cds1: linchpins of the DNA damage and replication checkpoint pathways.
@ast
Chk1 and Cds1: linchpins of the DNA damage and replication checkpoint pathways.
@en
type
label
Chk1 and Cds1: linchpins of the DNA damage and replication checkpoint pathways.
@ast
Chk1 and Cds1: linchpins of the DNA damage and replication checkpoint pathways.
@en
prefLabel
Chk1 and Cds1: linchpins of the DNA damage and replication checkpoint pathways.
@ast
Chk1 and Cds1: linchpins of the DNA damage and replication checkpoint pathways.
@en
P2860
P1476
Chk1 and Cds1: linchpins of the DNA damage and replication checkpoint pathways
@en
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P478
113 ( Pt 22)
P577
2000-11-01T00:00:00Z