Role for the proapoptotic factor BIM in mediating imatinib-induced apoptosis in a c-KIT-dependent gastrointestinal stromal tumor cell line
about
Regulation of Bim in Health and DiseaseA common BIM deletion polymorphism mediates intrinsic resistance and inferior responses to tyrosine kinase inhibitors in cancer.The conformational control inhibitor of tyrosine kinases DCC-2036 is effective for imatinib-resistant cells expressing T674I FIP1L1-PDGFRαBEX1 promotes imatinib-induced apoptosis by binding to and antagonizing BCL-2Antitumor activity of S116836, a novel tyrosine kinase inhibitor, against imatinib-resistant FIP1L1-PDGFRα-expressing cellsOncogenic Kit signals on endolysosomes and endoplasmic reticulum are essential for neoplastic mast cell proliferation.CDK inhibitors upregulate BH3-only proteins to sensitize human myeloma cells to BH3 mimetic therapies.M-COPA suppresses endolysosomal Kit-Akt oncogenic signalling through inhibiting the secretory pathway in neoplastic mast cells.Gefitinib-resistance is related to BIM expression in non-small cell lung cancer cell lines.Therapeutic targeting of c-KIT in cancer.The apoptotic effect of simvastatin via the upregulation of BIM in nonsmall cell lung cancer cells.MicroRNAs and Gastrointestinal Stromal Tumor.miRNA-221 and miRNA-222 induce apoptosis via the KIT/AKT signalling pathway in gastrointestinal stromal tumours.Correlation of glucocorticoid-mediated E4BP4 upregulation with altered expression of pro- and anti-apoptotic genes in CEM human lymphoblastic leukemia cells.Distinct signalling pathways for mutated KIT(V560G) and KIT(D816V) in mastocytosis.Synergistic induction of apoptosis by the Bcl-2 inhibitor ABT-737 and imatinib mesylate in gastrointestinal stromal tumor cells.Oncogenic signaling by Kit tyrosine kinase occurs selectively on the Golgi apparatus in gastrointestinal stromal tumors.Evaluating new therapies in gastrointestinal stromal tumor using in vivo molecular optical imagingThe BCL2L11 deletion polymorphism is not associated with imatinib resistance in chronic myeloid leukemia patients: meta-analysis.
P2860
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P2860
Role for the proapoptotic factor BIM in mediating imatinib-induced apoptosis in a c-KIT-dependent gastrointestinal stromal tumor cell line
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2010 nî lūn-bûn
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2010 թուականի Մարտին հրատարակուած գիտական յօդուած
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2010 թվականի մարտին հրատարակված գիտական հոդված
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2010年の論文
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2010年論文
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2010年論文
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Role for the proapoptotic fact ...... stinal stromal tumor cell line
@ast
Role for the proapoptotic fact ...... stinal stromal tumor cell line
@en
type
label
Role for the proapoptotic fact ...... stinal stromal tumor cell line
@ast
Role for the proapoptotic fact ...... stinal stromal tumor cell line
@en
prefLabel
Role for the proapoptotic fact ...... stinal stromal tumor cell line
@ast
Role for the proapoptotic fact ...... stinal stromal tumor cell line
@en
P2860
P356
P1476
Role for the proapoptotic fact ...... stinal stromal tumor cell line
@en
P2093
David E Fisher
Peter M Gordon
P2860
P304
14109-14114
P356
10.1074/JBC.M109.078592
P407
P577
2010-03-15T00:00:00Z