Bim and Bad mediate imatinib-induced killing of Bcr/Abl+ leukemic cells, and resistance due to their loss is overcome by a BH3 mimetic. - Wikidata - awgldk - TriplyDB

Bim and Bad mediate imatinib-induced killing of Bcr/Abl+ leukemic cells, and resistance due to their loss is overcome by a BH3 mimetic.

Bim and Bad mediate imatinib-induced killing of Bcr/Abl+ leukemic cells, and resistance due to their loss is overcome by a BH3 mimetic.

http://www.wikidata.org/entity/Q35075545

about

Chemical genomics identifies small-molecule MCL1 repressors and BCL-xL as a predictor of MCL1 dependency The Bcl-2 apoptotic switch in cancer development and therapy The BH3-only protein Puma plays an essential role in cytokine deprivation induced apoptosis of mast cells BH3 mimetics to improve cancer therapy; mechanisms and examples Regulation of Bim in Health and Disease Bcl-2 antagonists: a proof of concept for CLL therapy The BCL2 Family: Key Mediators of the Apoptotic Response to Targeted Anticancer Therapeutics How cell death shapes cancer Bcl-x(L) blocks a mitochondrial inner membrane channel and prevents Ca2+ overload-mediated cell death Mechanisms of acquired crizotinib resistance in ALK-rearranged lung Cancers.A common BIM deletion polymorphism mediates intrinsic resistance and inferior responses to tyrosine kinase inhibitors in cancer.betaTrCP- and Rsk1/2-mediated degradation of BimEL inhibits apoptosis Gefitinib-induced killing of NSCLC cell lines expressing mutant EGFR requires BIM and can be enhanced by BH3 mimetics Multi-agent chemotherapy overcomes glucocorticoid resistance conferred by a BIM deletion polymorphism in pediatric acute lymphoblastic leukemia Knockout Serum Replacement Promotes Cell Survival by Preventing BIM from Inducing Mitochondrial Cytochrome C Release Cyclic-AMP-dependent protein kinase A regulates apoptosis by stabilizing the BH3-only protein Bim BIM mediates EGFR tyrosine kinase inhibitor-induced apoptosis in lung cancers with oncogenic EGFR mutations MET-independent lung cancer cells evading EGFR kinase inhibitors are therapeutically susceptible to BH3 mimetic agents Why do cancer cells become "addicted" to oncogenic epidermal growth factor receptor?Therapeutic efficacy of ABT-737, a selective inhibitor of BCL-2, in small cell lung cancer ERK2, but not ERK1, mediates acquired and "de novo" resistance to imatinib mesylate: implication for CML therapy High BIM mRNA levels are associated with longer survival in advanced gastric cancer Bortezomib induces apoptosis in primitive chronic myeloid leukemia cells including LTC-IC and NOD/SCID repopulating cells.Apoptosis induced by JAK2 inhibition is mediated by Bim and enhanced by the BH3 mimetic ABT-737 in JAK2 mutant human erythroid cells.Bim and Mcl-1 exert key roles in regulating JAK2V617F cell survival.Role for the proapoptotic factor BIM in mediating imatinib-induced apoptosis in a c-KIT-dependent gastrointestinal stromal tumor cell line Deletion of Puma protects hematopoietic stem cells and confers long-term survival in response to high-dose gamma-irradiation.Bcl2 is not required for the development and maintenance of leukemia stem cells in mice.Cell death Clinical significance of BIM deletion polymorphism in non-small-cell lung cancer with epidermal growth factor receptor mutation.Targeting the translational apparatus to improve leukemia therapy: roles of the PI3K/PTEN/Akt/mTOR pathway.Interleukin 15-mediated survival of natural killer cells is determined by interactions among Bim, Noxa and Mcl-1.Individual and overlapping roles of BH3-only proteins Bim and Bad in apoptosis of lymphocytes and platelets and in suppression of thymic lymphoma development Pharmacokinetic modeling of an induction regimen for in vivo combined testing of novel drugs against pediatric acute lymphoblastic leukemia xenografts.Association of differential gene expression with imatinib mesylate and omacetaxine mepesuccinate toxicity in lymphoblastoid cell lines.Cell metabolism: an essential link between cell growth and apoptosis Synergistic induction of cell death in liver tumor cells by TRAIL and chemotherapeutic drugs via the BH3-only proteins Bim and Bid Tyrosine kinase inhibitors: Multi-targeted or single-targeted?Imatinib spells BAD news for Bcr/abl-positive leukemias The essential role of evasion from cell death in cancer.

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Bim and Bad mediate imatinib-induced killing of Bcr/Abl+ leukemic cells, and resistance due to their loss is overcome by a BH3 mimetic.

http://www.wikidata.org/entity/Q35075545

description

2006 nî lūn-bûn

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2006 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

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2006 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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2006年の論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年论文

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Bim and Bad mediate imatinib-i ...... is overcome by a BH3 mimetic.

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Bim and Bad mediate imatinib-i ...... is overcome by a BH3 mimetic.

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type

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Bim and Bad mediate imatinib-i ...... is overcome by a BH3 mimetic.

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Bim and Bad mediate imatinib-i ...... is overcome by a BH3 mimetic.

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Bim and Bad mediate imatinib-i ...... is overcome by a BH3 mimetic.

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Bim and Bad mediate imatinib-i ...... is overcome by a BH3 mimetic.

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Proceedings of the National Academy of Sciences of the United States of America

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Bim and Bad mediate imatinib-i ...... s is overcome by a BH3 mimetic

@en

P2093

Andreas Villunger

http://www.w3.org/2001/XMLSchema#string

Junya Kuroda

http://www.w3.org/2001/XMLSchema#string

Priscilla N Kelly

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Shinya Kimura

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P2860

Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis

Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function

Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity

p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa

Puma is an essential mediator of p53-dependent and -independent apoptotic pathways

Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)

Polycystic kidney disease prevented by transgenic RNA interference

An inhibitor of Bcl-2 family proteins induces regression of solid tumours

The pathophysiology of mitochondrial cell death

Apoptosis signaling.

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14907-14912

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scholarly article

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10.1073/PNAS.0606176103

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40

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103

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Brian J. Druker

Andreas Strasser

Philippe Bouillet

Andrew W Roberts

Hamsa Puthalakath

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2006-09-22T00:00:00Z

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6796530

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16997913

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1595449

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