Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus
about
The PI3K/Akt Pathway in Tumors of Endocrine TissuesTargeting the PI3K/Akt signaling pathway in gastric carcinoma: A reality for personalized medicine?A new perspective on the role of the CREB family of transcription factors in memory consolidation via adult hippocampal neurogenesisApplications of targeted proteomics in systems biology and translational medicineRegulation of mTORC1 by PI3K signalingPhosphorylation of Akt at the C-terminal tail triggers Akt activationPosttranslational regulation of Akt in human cancerSimulated Microgravity and 3D Culture Enhance Induction, Viability, Proliferation and Differentiation of Cardiac Progenitors from Human Pluripotent Stem CellsThe phosphoinositide 3-kinase pathway and therapy resistance in cancermTOR signaling in tumorigenesisThe Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and AgingSet7 mediated Gli3 methylation plays a positive role in the activation of Sonic Hedgehog pathway in mammalsRegulation of PI3K effector signalling in cancer by the phosphoinositide phosphatasesPhosphoproteomics in the Age of Rapid and Deep Proteome Profiling.Regulation of NADPH-dependent Nitric Oxide and reactive oxygen species signalling in endothelial and melanoma cells by a photoactive NADPH analogue.Acetylation-dependent regulation of MDM2 E3 ligase activity dictates its oncogenic function.Avian reovirus p17 and σA act cooperatively to downregulate Akt by suppressing mTORC2 and CDK2/cyclin A2 and upregulating proteasome PSMB6.Cell-cycle reprogramming for PI3K inhibition overrides a relapse-specific C481S BTK mutation revealed by longitudinal functional genomics in mantle cell lymphomaSignaling mechanisms that suppress the cytostatic actions of rapamycinExtra-Nuclear Signaling Pathway Involved in Progesterone-Induced Up-Regulations of p21cip1 and p27kip1 in Male Rat Aortic Smooth Muscle Cells.Blocking anaplerotic entry of glutamine into the TCA cycle sensitizes K-Ras mutant cancer cells to cytotoxic drugs.Threonine 34 phosphorylation by phosphoinositide-dependent protein kinase 1 facilitates dissociation of Akt from the plasma membrane.Ligand-based chemoinformatic discovery of a novel small molecule inhibitor targeting CDC25 dual specificity phosphatases and displaying in vitro efficacy against melanoma cellsA comparison of phosphospecific affinity reagents reveals the utility of recombinant Forkhead-associated domains in recognizing phosphothreonine-containing peptides.RasGAP Shields Akt from Deactivating Phosphatases in Fibroblast Growth Factor Signaling but Loses This Ability Once Cleaved by Caspase-3.Apoptotic effects of high-dose rapamycin occur in S-phase of the cell cycle.PtdIns(3,4,5)P3-Dependent Activation of the mTORC2 Kinase Complex.p27kip1 controls H-Ras/MAPK activation and cell cycle entry via modulation of MT stability.Meiotic failure in cyclin A1-deficient mouse spermatocytes triggers apoptosis through intrinsic and extrinsic signaling pathways and 14-3-3 proteinsPhosphorylation-mediated EZH2 inactivation promotes drug resistance in multiple myeloma.Radiosensitizing effect of diosmetin on radioresistant lung cancer cells via Akt signaling pathway.Cyclin-dependent kinase 2 protects podocytes from apoptosisThe BH3-mimetic gossypol and noncytotoxic doses of valproic acid induce apoptosis by suppressing cyclin-A2/Akt/FOXO3a signaling.Capillary Isoelectric Focusing of Akt Isoforms Identifies Highly Dynamic Phosphorylation in Neuronal Cells and Brain TissueFANCI is a negative regulator of Akt activation.Two new competing pathways establish the threshold for cyclin-B-Cdk1 activation at the meiotic G2/M transition.Magnolol and honokiol exert a synergistic anti-tumor effect through autophagy and apoptosis in human glioblastomas.Akt-mediated foxo1 inhibition is required for liver regeneration.The SCFβ-TRCP E3 ubiquitin ligase complex targets Lipin1 for ubiquitination and degradation to promote hepatic lipogenesis.pVHL suppresses kinase activity of Akt in a proline-hydroxylation-dependent manner.
P2860
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P2860
Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus
description
2014 nî lūn-bûn
@nan
2014 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի մարտին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus
@ast
Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus
@en
type
label
Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus
@ast
Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus
@en
prefLabel
Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus
@ast
Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus
@en
P2093
P2860
P50
P921
P356
P1433
P1476
Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus
@en
P2093
Alex Toker
Amrik Singh
Hiroyuki Inuzuka
John M Asara
Kun-Ping Lu
Marc W Kirschner
Michael Begley
P2860
P2888
P304
P356
10.1038/NATURE13079
P407
P50
P577
2014-03-09T00:00:00Z