about
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A probability-based approach for high-throughput protein phosphorylation analysis and site localizationAcetylation-dependent regulation of Skp2 functionHuman ESCRT and ALIX proteins interact with proteins of the midbody and function in cytokinesis.Activation of multiple proto-oncogenic tyrosine kinases in breast cancer via loss of the PTPN12 phosphatasePhosphorylation by casein kinase I promotes the turnover of the Mdm2 oncoprotein via the SCF(beta-TRCP) ubiquitin ligaseAutoubiquitination of the 26S proteasome on Rpn13 regulates breakdown of ubiquitin conjugatesThe Parkinson's disease-associated DJ-1 protein is a transcriptional co-activator that protects against neuronal apoptosisATP is required for interactions between UAP56 and two conserved mRNA export proteins, Aly and CIP29, to assemble the TREX complexIdentification of human MVB12 proteins as ESCRT-I subunits that function in HIV buddingLarge-scale characterization of HeLa cell nuclear phosphoproteinsHem-1 complexes are essential for Rac activation, actin polymerization, and myosin regulation during neutrophil chemotaxisAn OBSL1-Cul7Fbxw8 ubiquitin ligase signaling mechanism regulates Golgi morphology and dendrite patterningA UAF1-containing multisubunit protein complex regulates the Fanconi anemia pathwayThe tumor suppressor CYLD regulates entry into mitosisA genome-wide camptothecin sensitivity screen identifies a mammalian MMS22L-NFKBIL2 complex required for genomic stabilityATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damageAbraxas and RAP80 form a BRCA1 protein complex required for the DNA damage responseThe intraflagellar transport protein IFT27 promotes BBSome exit from cilia through the GTPase ARL6/BBS3.Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylaseOxygen-regulated beta(2)-adrenergic receptor hydroxylation by EGLN3 and ubiquitylation by pVHLIdentification of FBXO25-interacting proteins using an integrated proteomics approachAn FTS/Hook/p107(FHIP) complex interacts with and promotes endosomal clustering by the homotypic vacuolar protein sorting complexTIMMDC1/C3orf1 functions as a membrane-embedded mitochondrial complex I assembly factor through association with the MCIA complexA high-confidence interaction map identifies SIRT1 as a mediator of acetylation of USP22 and the SAGA coactivator complexMammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repairCharacterization of the deubiquitinating activity of USP19 and its role in endoplasmic reticulum-associated degradationA conserved CCCH-type zinc finger protein regulates mRNA nuclear adenylation and exportDefining the human deubiquitinating enzyme interaction landscapeSDH5, a gene required for flavination of succinate dehydrogenase, is mutated in paragangliomaConstitutive activated Cdc42-associated kinase (Ack) phosphorylation at arrested endocytic clathrin-coated pits of cells that lack dynaminChaperone-mediated pathway of proteasome regulatory particle assemblyNetwork organization of the human autophagy systemUAF1 is a subunit of multiple deubiquitinating enzyme complexesAbelson phosphorylation of CLASP2 modulates its association with microtubules and actinProteomic analysis of cap-dependent translation identifies LARP1 as a key regulator of 5'TOP mRNA translationThe conserved Bardet-Biedl syndrome proteins assemble a coat that traffics membrane proteins to ciliaQIL1 is a novel mitochondrial protein required for MICOS complex stability and cristae morphologyA conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life spanThe histone demethylase LSD1/KDM1A promotes the DNA damage responseHuman ISG15 conjugation targets both IFN-induced and constitutively expressed proteins functioning in diverse cellular pathways
P50
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P50
description
researcher
@en
wetenschapper
@nl
name
Steven P Gygi
@en
Steven P Gygi
@nl
type
label
Steven P Gygi
@en
Steven P Gygi
@nl
prefLabel
Steven P Gygi
@en
Steven P Gygi
@nl
P31
P496
0000-0001-7626-0034