The IL23R R381Q gene variant protects against immune-mediated diseases by impairing IL-23-induced Th17 effector response in humans - Wikidata - awgldk - TriplyDB

The IL23R R381Q gene variant protects against immune-mediated diseases by impairing IL-23-induced Th17 effector response in humans

The IL23R R381Q gene variant protects against immune-mediated diseases by impairing IL-23-induced Th17 effector response in humans

http://www.wikidata.org/entity/Q33833964

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Deep resequencing of GWAS loci identifies independent rare variants associated with inflammatory bowel disease Review: The interleukin-23/interleukin-17 axis in spondyloarthritis pathogenesis: Th17 and beyond Immunology of psoriasis Putting together the psoriasis puzzle: an update on developing targeted therapies IL-17A is essential for cell activation and inflammatory gene circuits in subjects with psoriasis Functional studies on the IBD susceptibility gene IL23R implicate reduced receptor function in the protective genetic variant R381Q Combined analysis of genome-wide association studies for Crohn disease and psoriasis identifies seven shared susceptibility loci Genetics and pathogenesis of inflammatory bowel disease Genetic variation in IBD: progress, clues to pathogenesis and possible clinical utility Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity.Investigation of a possible extended risk haplotype in the IL23R region associated with ankylosing spondylitis.Autoimmunity's collateral damage: Gut microbiota strikes 'back'.Therapeutic targeting of the IL-12/23 pathways: generation and characterization of ustekinumab.Discovery and mechanism of ustekinumab: a human monoclonal antibody targeting interleukin-12 and interleukin-23 for treatment of immune-mediated disorders.Effector CD4+ T cell expression signatures and immune-mediated disease associated genes.Meta-analysis derived (MAD) transcriptome of psoriasis defines the "core" pathogenesis of disease Age and CD161 expression contribute to inter-individual variation in interleukin-23 response in CD8+ memory human T cells Genetic Epidemiology of Psoriasis No evidence of association between common autoimmunity STAT4 and IL23R risk polymorphisms and non-anterior uveitis.Immunology of inflammatory bowel disease and molecular targets for biologics.Association between Psoriasis Vulgaris and Coronary Heart Disease in a Hospital-Based Population in Japan.Regulatory T-cell Response to Enterotoxigenic Bacteroides fragilis Colonization Triggers IL17-Dependent Colon Carcinogenesis.IL23R(Arg381Gln) functional polymorphism is associated with active pulmonary tuberculosis severity.The immunogenetics of Psoriasis: A comprehensive review.Update on psoriasis immunopathogenesis and targeted immunotherapy.Variations in IL-23 and IL-25 receptor gene structure, sequence and expression associated with the two disease forms of sheep paratuberculosis GWAS implicates a role for quantitative immune traits and threshold effects in risk for human autoimmune disorders Fine mapping of eight psoriasis susceptibility loci.IL23R (Interleukin 23 Receptor) Variants Protective against Inflammatory Bowel Diseases (IBD) Display Loss of Function due to Impaired Protein Stability and Intracellular Trafficking.The IL-23/T17 pathogenic axis in psoriasis is amplified by keratinocyte responses.The IL23R A/Gln381 allele promotes IL-23 unresponsiveness in human memory T-helper 17 cells and impairs Th17 responses in psoriasis patients Network-based SNP meta-analysis identifies joint and disjoint genetic features across common human diseases.Updates on Psoriasis and Cutaneous Oncology: Proceedings from the 2013 MauiDerm Meeting.Clinical consequences of targeting IL-17 and TH17 in autoimmune and allergic disorders An ankylosing spondylitis-associated genetic variant in the IL23R-IL12RB2 intergenic region modulates enhancer activity and is associated with increased Th1-cell differentiation.Interleukin-23 as a potential therapeutic target for rheumatoid arthritis.Cytokine gene polymorphisms and human autoimmune disease in the era of genome-wide association studies Critical role of the interleukin-23/T-helper 17 cell axis in the pathogenesis of psoriasis.The IL-23/IL-17 pathway in inflammatory bowel disease.Psoriasis drug discovery: methods for evaluation of potential drug candidates.

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The IL23R R381Q gene variant protects against immune-mediated diseases by impairing IL-23-induced Th17 effector response in humans

http://www.wikidata.org/entity/Q33833964

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2011 nî lūn-bûn

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2011 թուականի Փետրուարին հրատարակուած գիտական յօդուած

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2011 թվականի փետրվարին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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name

The IL23R R381Q gene variant p ...... 17 effector response in humans

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The IL23R R381Q gene variant p ...... 17 effector response in humans

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The IL23R R381Q gene variant p ...... 17 effector response in humans

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The IL23R R381Q gene variant p ...... 17 effector response in humans

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The IL23R R381Q gene variant p ...... 17 effector response in humans

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The IL23R R381Q gene variant p ...... 17 effector response in humans

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JOURNAL.PONE.0017160

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The IL23R R381Q gene variant p ...... 17 effector response in humans

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Antonella Di Cesare

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Chung-Ching Chu

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Federica Villanova

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Frank O Nestle

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Isabella Tosi

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Luca Napolitano

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Ute Laggner

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P2860

Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12

A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R

IL-23 and IL-12 responses in activated human T cells retrovirally transduced with IL-23 receptor variants

The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17-producing effector T helper cells in vivo

The differentiation of human T(H)-17 cells requires transforming growth factor-beta and induction of the nuclear receptor RORgammat

Increased expression of interleukin 23 p19 and p40 in lesional skin of patients with psoriasis vulgaris

Interleukin-23 drives innate and T cell-mediated intestinal inflammation

A large-scale genetic association study confirms IL12B and leads to the identification of IL23R as psoriasis-risk genes

IL-17 and Th17 Cells

Comparison of ustekinumab and etanercept for moderate-to-severe psoriasis

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e17160

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scholarly article

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10.1371/JOURNAL.PONE.0017160

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2

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Richard C Trembath

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Paola Di Meglio

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2011-02-22T00:00:00Z

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50250866

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21364948

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3043090

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