TGF-beta signaling blockade inhibits PTHrP secretion by breast cancer cells and bone metastases development. - Wikidata - awgldk - TriplyDB

TGF-beta signaling blockade inhibits PTHrP secretion by breast cancer cells and bone metastases development.

TGF-beta signaling blockade inhibits PTHrP secretion by breast cancer cells and bone metastases development.

http://www.wikidata.org/entity/Q33834762

about

Hypoxia and TGF-beta drive breast cancer bone metastases through parallel signaling pathways in tumor cells and the bone microenvironment.The biology of the Ets1 proto-oncogene Type III TGF-beta receptor-independent signalling of TGF-beta2 via TbetaRII-B, an alternatively spliced TGF-beta type II receptor Breast cancer bone metastasis mediated by the Smad tumor suppressor pathway Epidermal growth factor signaling via Ras controls the Smad transcriptional co-repressor TGIF.Latent bone metastasis in breast cancer tied to Src-dependent survival signals Transforming growth factor beta signaling impairs Neu-induced mammary tumorigenesis while promoting pulmonary metastasis Granulocyte colony-stimulating factor enhances bone tumor growth in mice in an osteoclast-dependent manner Transforming growth factor-beta and breast cancer: Lessons learned from genetically altered mouse models Transforming growth factor-beta and breast cancer: Transforming growth factor-beta/SMAD signaling defects and cancer.Transforming growth factor-beta and breast cancer: Tumor promoting effects of transforming growth factor-beta Molecular biology of breast cancer metastasis. 'Has it spread?': disarming one of the most terrifying questions Molecular biology of breast cancer metastasis. Genetic regulation of human breast carcinoma metastasis.Actions of bisphosphonates in animal models of breast cancer Lead exposure inhibits fracture healing and is associated with increased chondrogenesis, delay in cartilage mineralization, and a decrease in osteoprogenitor frequency.Suppression of NADPH Oxidase Activity May Slow the Expansion of Osteolytic Bone Metastases Prostate cancer metastasis: roles of recruitment and reprogramming, cell signal network and three-dimensional growth characteristics Molecular alterations that drive breast cancer metastasis to bone The Roles of Epithelial-to-Mesenchymal Transition (EMT) and Mesenchymal-to-Epithelial Transition (MET) in Breast Cancer Bone Metastasis: Potential Targets for Prevention and Treatment At the crossroads: EGFR and PTHrP signaling in cancer-mediated diseases of bone Transcriptional control of cancer metastasis TGF-β/SMAD/GLI2 signaling axis in cancer progression and metastasis Bone specific immunity and its impact on metastasis Role of Parathyroid Hormone-Related Protein Signaling in Chronic Pancreatitis Targeting tumor-stromal interactions in bone metastasis Doxorubicin-mediated bone loss in breast cancer bone metastases is driven by an interplay between oxidative stress and induction of TGFβ Cell density sensing alters TGF-β signaling in a cell-type-specific manner, independent from Hippo pathway activation Quantitative ex-vivo micro-computed tomographic imaging of blood vessels and necrotic regions within tumors.The role of the BMP signaling antagonist noggin in the development of prostate cancer osteolytic bone metastasis The calcium-sensing receptor in the breast.Biology of bone metastases.Calcium-Sensing Receptor in Breast Physiology and Cancer Tumor cell dormancy Metastatic colonization by circulating tumour cells TGF-β Signaling in Bone Remodeling and Osteosarcoma Progression Switching Roles of TGF-β in Cancer Development: Implications for Therapeutic Target and Biomarker Studies Smad2 and Smad3 have opposing roles in breast cancer bone metastasis by differentially affecting tumor angiogenesis TGFbeta primes breast tumors for lung metastasis seeding through angiopoietin-like 4 TGFbeta in Cancer Modern pathogenetic concepts of liver fibrosis suggest stellate cells and TGF-beta as major players and therapeutic targets

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P2860

TGF-beta signaling blockade inhibits PTHrP secretion by breast cancer cells and bone metastases development.

http://www.wikidata.org/entity/Q33834762

description

1999 nî lūn-bûn

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1999 թուականի Յունուարին հրատարակուած գիտական յօդուած

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1999 թվականի հունվարին հրատարակված գիտական հոդված

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1999年の論文

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B G Grubbs

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G R Mundy

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P2860

TGF-beta signal transduction

MADR2 maps to 18q21 and encodes a TGFbeta-regulated MAD-related protein that is functionally mutated in colorectal carcinoma

Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability

Parathyroid hormone-related protein purified from a human lung cancer cell line

Type I receptors specify growth-inhibitory and transcriptional responses to transforming growth factor beta and activin

Opposing BMP and EGF signalling pathways converge on the TGF-beta family mediator Smad1

Intestinal tumorigenesis in compound mutant mice of both Dpc4 (Smad4) and Apc genes

Expression cloning of a common receptor for parathyroid hormone and parathyroid hormone-related peptide from rat osteoblast-like cells: a single receptor stimulates intracellular accumulation of both cAMP and inositol trisphosphates and increases in

The distribution of secondary growths in cancer of the breast. 1889

DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1

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