Progestins induce transcriptional activation of signal transducer and activator of transcription 3 (Stat3) via a Jak- and Src-dependent mechanism in breast cancer cells
about
Downregulation of the tumor-suppressor miR-16 via progestin-mediated oncogenic signaling contributes to breast cancer developmentProgesterone receptor induces ErbB-2 nuclear translocation to promote breast cancer growth via a novel transcriptional effect: ErbB-2 function as a coactivator of Stat3Multimodal regulation of E2F1 gene expression by progestinsInteraction of JAK with steroid receptor functionProgestins activate 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3) in breast cancer cellsDrug development against metastasis-related genes and their pathways: A rationale for cancer therapyLinkage of progestin and epidermal growth factor signaling: phosphorylation of progesterone receptors mediates transcriptional hypersensitivity and increased ligand-independent breast cancer cell growth.Signal transducer and activator of transcription 3 is involved in cell growth and survival of human rhabdomyosarcoma and osteosarcoma cellsProgesterone receptor rapid signaling mediates serine 345 phosphorylation and tethering to specificity protein 1 transcription factors.Progesterone receptors act as sensors for mitogenic protein kinases in breast cancer models.Signaling inputs to progesterone receptor gene regulation and promoter selectivity.Heregulin Co-opts PR Transcriptional Action Via Stat3 Role As a Coregulator to Drive Cancer Growth.Progesterone and breast cancer.Activation of progestin receptors in female reproductive behavior: Interactions with neurotransmittersThe transcriptional STAT3 is a potential target, whereas transcriptional STAT5A/5B/6 are new biomarkers for prognosis in human breast carcinoma.Progesterone receptor action: defining a role in breast cancerProgestogens used in postmenopausal hormone therapy: differences in their pharmacological properties, intracellular actions, and clinical effectsCyclin A2 and its associated kinase activity are required for optimal induction of progesterone receptor target genes in breast cancer cellsProgesterone receptor activation downregulates GATA3 by transcriptional repression and increased protein turnover promoting breast tumor growthHck is a key regulator of gene expression in alternatively activated human monocytesStructural and functional analysis of domains of the progesterone receptor.The biology of progesterone receptor in the normal mammary gland and in breast cancerProgesterone signaling mechanisms in brain and behavior.Adaptor protein-3 in dendritic cells facilitates phagosomal toll-like receptor signaling and antigen presentation to CD4(+) T cells.Neural progestin receptors and female sexual behavior.Immunolocalisation of phosphorylated STAT3, interleukin 11 and leukaemia inhibitory factor in endometrium of women with unexplained infertility during the implantation window.Integration of progesterone receptor action with rapid signaling events in breast cancer models.Active FOXO1 Is a Key Determinant of Isoform-Specific Progesterone Receptor Transactivation and Senescence Programming.Progesterone induction of the 11beta-hydroxysteroid dehydrogenase type 2 promoter in breast cancer cells involves coordinated recruitment of STAT5A and progesterone receptor to a distal enhancer and polymerase trackingCrosstalk between signaling pathways of adrenoreceptors and signal transducers and activators of transcription 3 (STAT3) in heart.Challenges to defining a role for progesterone in breast cancer.Progesterone receptor isoforms PRA and PRB differentially contribute to breast cancer cell migration through interaction with focal adhesion kinase complexesSTAT3 expression correlates with prognosis of thymic epithelial tumors.Physalin A exerts anti-tumor activity in non-small cell lung cancer cell lines by suppressing JAK/STAT3 signaling.Activation of Stat3 by heregulin/ErbB-2 through the co-option of progesterone receptor signaling drives breast cancer growth.Positive feedback regulation between IL10 and EGFR promotes lung cancer formation.Research resource: progesterone receptor targetome underlying mammary gland branching morphogenesisProgesterone receptor and Stat5 signaling cross talk through RANKL in mammary epithelial cells.Progesterone receptor assembly of a transcriptional complex along with activator protein 1, signal transducer and activator of transcription 3 and ErbB-2 governs breast cancer growth and predicts response to endocrine therapy.Mutational analysis of progesterone receptor functional domains in stable cell lines delineates sets of genes regulated by different mechanisms.
P2860
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P2860
Progestins induce transcriptional activation of signal transducer and activator of transcription 3 (Stat3) via a Jak- and Src-dependent mechanism in breast cancer cells
description
2005 nî lūn-bûn
@nan
2005 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Progestins induce transcriptio ...... chanism in breast cancer cells
@ast
Progestins induce transcriptio ...... chanism in breast cancer cells
@en
type
label
Progestins induce transcriptio ...... chanism in breast cancer cells
@ast
Progestins induce transcriptio ...... chanism in breast cancer cells
@en
prefLabel
Progestins induce transcriptio ...... chanism in breast cancer cells
@ast
Progestins induce transcriptio ...... chanism in breast cancer cells
@en
P2093
P2860
P1476
Progestins induce transcriptio ...... chanism in breast cancer cells
@en
P2093
Adalí Pecci
Alfredo A Molinolo
Cecilia Proietti
Cinthia Rosemblit
Eduardo H Charreau
Isabel Frahm
Mariana Salatino
Romina Carnevale
Roxana Schillaci
P2860
P304
P356
10.1128/MCB.25.12.4826-4840.2005
P407
P577
2005-06-01T00:00:00Z