Role of vaccinia virus A20R protein in DNA replication: construction and characterization of temperature-sensitive mutants.
about
Members of a novel family of mammalian protein kinases complement the DNA-negative phenotype of a vaccinia virus ts mutant defective in the B1 kinaseOrigin-independent plasmid replication occurs in vaccinia virus cytoplasmic factories and requires all five known poxvirus replication factorsHuman cytomegalovirus uracil DNA glycosylase associates with ppUL44 and accelerates the accumulation of viral DNA.Vaccinia Virus D4 Mutants Defective in Processive DNA Synthesis Retain Binding to A20 and DNACrystal structure of the vaccinia virus DNA polymerase holoenzyme subunit D4 in complex with the A20 N-terminal domainPoxvirus DNA replicationVaccinia H5 is a multifunctional protein involved in viral DNA replication, postreplicative gene transcription, and virion morphogenesis.Repression of vaccinia virus Holliday junction resolvase inhibits processing of viral DNA into unit-length genomes.Vaccinia virus intracellular movement is associated with microtubules and independent of actin tailsVaccinia virus uracil DNA glycosylase has an essential role in DNA synthesis that is independent of its glycosylase activity: catalytic site mutations reduce virulence but not virus replication in cultured cells.Mapping and functional analysis of interaction sites within the cytoplasmic domains of the vaccinia virus A33R and A36R envelope proteinsEvaluation of the role of the vaccinia virus uracil DNA glycosylase and A20 proteins as intrinsic components of the DNA polymerase holoenzyme.Identification of inhibitors that block vaccinia virus infection by targeting the DNA synthesis processivity factor D4.Biochemical and genetic analysis of the vaccinia virus d5 protein: Multimerization-dependent ATPase activity is required to support viral DNA replicationMolecular genetic and biochemical characterization of the vaccinia virus I3 protein, the replicative single-stranded DNA binding protein.Orthopoxvirus targets for the development of antiviral therapies.Biochemical and biophysical properties of a putative hub protein expressed by vaccinia virus.Effects of vaccinia virus uracil DNA glycosylase catalytic site and deoxyuridine triphosphatase deletion mutations individually and together on replication in active and quiescent cells and pathogenesis in mice.Vaccinia virus mutants with alanine substitutions in the conserved G5R gene fail to initiate morphogenesis at the nonpermissive temperature.Marker rescue mapping of the combined Condit/Dales collection of temperature-sensitive vaccinia virus mutants.Vaccinia Virus B1 Kinase Is Required for Postreplicative Stages of the Viral Life Cycle in a BAF-Independent Manner in U2OS Cells.Genetic Confirmation that the H5 Protein Is Required for Vaccinia Virus DNA Replication.Poxvirus uracil-DNA glycosylase-An unusual member of the family I uracil-DNA glycosylases.The vaccinia virus DNA polymerase and its processivity factor.Clustered charge-to-alanine mutagenesis of the vaccinia virus A20 gene: temperature-sensitive mutants have a DNA-minus phenotype and are defective in the production of processive DNA polymerase activity.Characterisation of the substrate specificity of homogeneous vaccinia virus uracil-DNA glycosylase.Genetic analysis of the vaccinia virus I6 telomere-binding protein uncovers a key role in genome encapsidation.Vaccinia virus A6L encodes a virion core protein required for formation of mature virion.Vaccinia virus uracil DNA glycosylase interacts with the A20 protein to form a heterodimeric processivity factor for the viral DNA polymerase.A Conserved Tripeptide Sequence at the C Terminus of the Poxvirus DNA Processivity Factor D4 Is Essential for Protein Integrity and Function.Vaccinia virus A6 is essential for virion membrane biogenesis and localization of virion membrane proteins to sites of virion assemblyPurification and properties of the vaccinia virus mRNA processing factor.
P2860
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P2860
Role of vaccinia virus A20R protein in DNA replication: construction and characterization of temperature-sensitive mutants.
description
2001 nî lūn-bûn
@nan
2001 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Role of vaccinia virus A20R pr ...... temperature-sensitive mutants.
@ast
Role of vaccinia virus A20R pr ...... temperature-sensitive mutants.
@en
type
label
Role of vaccinia virus A20R pr ...... temperature-sensitive mutants.
@ast
Role of vaccinia virus A20R pr ...... temperature-sensitive mutants.
@en
prefLabel
Role of vaccinia virus A20R pr ...... temperature-sensitive mutants.
@ast
Role of vaccinia virus A20R pr ...... temperature-sensitive mutants.
@en
P2860
P1433
P1476
Role of vaccinia virus A20R pr ...... temperature-sensitive mutants.
@en
P2860
P304
P356
10.1128/JVI.75.4.1656-1663.2001
P577
2001-02-01T00:00:00Z