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Applications of (19)F-NMR in Fragment-Based Drug DiscoveryProtein-Directed Dynamic Combinatorial Chemistry: A Guide to Protein Ligand and Inhibitor DiscoveryProcess of Fragment-Based Lead Discovery-A Perspective from NMRCapturing Biological Activity in Natural Product Fragments by Chemical SynthesisFine-tuning multiprotein complexes using small moleculesProtein flexibility in docking and surface mappingFeatures of protein-protein interactions that translate into potent inhibitors: topology, surface area and affinityExpanding the number of 'druggable' targets: non-enzymes and protein-protein interactionsA Fragment-Based Approach to Probing Adenosine Recognition Sites by Using Dynamic Combinatorial ChemistryFragment-based screening by X-ray crystallography, MS and isothermal titration calorimetry to identify PNMT (phenylethanolamine N-methyltransferase) inhibitorsDiscovery of an allosteric mechanism for the regulation of HCV NS3 protein functionDissecting Fragment-Based Lead Discovery at the von Hippel-Lindau Protein:Hypoxia Inducible Factor 1α Protein-Protein InterfaceDiscovery of Potent Myeloid Cell Leukemia 1 (Mcl-1) Inhibitors Using Fragment-Based Methods and Structure-Based DesignAssembly of a π–π stack of ligands in the binding site of an acetylcholine-binding proteinFragment-based screening maps inhibitor interactions in the ATP-binding site of checkpoint kinase 2Integrated biophysical approach to fragment screening and validation for fragment-based lead discoveryCrystal Structure of Human Soluble Adenylate Cyclase Reveals a Distinct, Highly Flexible Allosteric Bicarbonate Binding PocketSynthesis and structural characterisation of selective non-carbohydrate-based inhibitors of bacterial sialidasesParallel screening of low molecular weight fragment libraries: do differences in methodology affect hit identification?Natural-product-derived fragments for fragment-based ligand discoveryMissing Fragments: Detecting Cooperative Binding in Fragment-Based Drug DesignFragment-Based Discovery of 6-Azaindazoles As Inhibitors of Bacterial DNA LigaseDeconstruction of a Nutlin: Dissecting the Binding Determinants of a Potent Protein–Protein Interaction InhibitorA natural-product switch for a dynamic protein interfaceDe Novo Fragment Design for Drug Discovery and Chemical BiologyMining significant substructure pairs for interpreting polypharmacology in drug-target networkAutomated NMR fragment based screening identified a novel interface blocker to the LARG/RhoA complexCapturing nature's diversityEnhancements to the Rosetta Energy Function Enable Improved Identification of Small Molecules that Inhibit Protein-Protein InteractionsACFIS: a web server for fragment-based drug discoveryStructure-based inhibition of protein-protein interactions.Detection of secondary binding sites in proteins using fragment screeningTargeting Non-Catalytic Cysteine Residues Through Structure-Guided Drug DiscoveryNMR-based analysis of protein-ligand interactions.Fragment-based discovery of a new family of non-peptidic small-molecule cyclophilin inhibitors with potent antiviral activitiesDetermination of ligand binding modes in weak protein-ligand complexes using sparse NMR data.Discovery of β2 Adrenergic Receptor Ligands Using Biosensor Fragment Screening of Tagged Wild-Type Receptor.Nucleophilic catalysis of acylhydrazone equilibration for protein-directed dynamic covalent chemistryHTS and hit finding in academia--from chemical genomics to drug discovery.Targeting YAP/TAZ-TEAD protein-protein interactions using fragment-based and computational modeling approaches.
P2860
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P2860
description
2009 nî lūn-bûn
@nan
2009 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
The rise of fragment-based drug discovery.
@ast
The rise of fragment-based drug discovery.
@en
type
label
The rise of fragment-based drug discovery.
@ast
The rise of fragment-based drug discovery.
@en
prefLabel
The rise of fragment-based drug discovery.
@ast
The rise of fragment-based drug discovery.
@en
P356
P1433
P1476
The rise of fragment-based drug discovery.
@en
P2093
Christopher W Murray
David C Rees
P2860
P2888
P304
P356
10.1038/NCHEM.217
P577
2009-06-01T00:00:00Z
P5875
P6179
1015868823