Integrated biophysical approach to fragment screening and validation for fragment-based lead discovery
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Substrate Deconstruction and the Nonadditivity of Enzyme RecognitionIncreasing Chemical Space Coverage by Combining Empirical and Computational Fragment ScreensCrystal structure of an arginase-like protein from Trypanosoma brucei that evolved without a binuclear manganese cluster.A ligand-observed mass spectrometry approach integrated into the fragment based lead discovery pipeline.Identification of mechanistically distinct inhibitors of HIV-1 reverse transcriptase through fragment screening.The tuberculosis drug discovery and development pipeline and emerging drug targets.One Question, Multiple Answers: Biochemical and Biophysical Screening Methods Retrieve Deviating Fragment Hit Lists.Structure-based Design Targeted at LOX-1, a Receptor for Oxidized Low-Density Lipoprotein.Fragment library screening identifies hits that bind to the non-catalytic surface of Pseudomonas aeruginosa DsbA1Investigation of the mycobacterial enzyme HsaD as a potential novel target for anti-tubercular agents using a fragment-based drug design approach.Reaction intermediate analogues as bisubstrate inhibitors of pantothenate synthetase.Dub3 inhibition suppresses breast cancer invasion and metastasis by promoting Snail1 degradation.Oncogenic protein interfaces: small molecules, big challenges.Tuberculosis drug discovery and emerging targets.The impact of binding thermodynamics on medicinal chemistry optimizations.Biophysics: for HTS hit validation, chemical lead optimization, and beyond.Structure-guided design of thiazolidine derivatives as Mycobacterium tuberculosis pantothenate synthetase inhibitors.Competitive binding of a benzimidazole to the histone-binding pocket of the Pygo PHD finger.Protein crystallography and drug discovery: recollections of knowledge exchange between academia and industry.Targeting Bacillosamine Biosynthesis in Bacterial Pathogens: Development of Inhibitors to a Bacterial Amino-Sugar Acetyltransferase from Campylobacter jejuni.Hot-spot identification on a broad class of proteins and RNA suggest unifying principles of molecular recognition.Peptide-Directed Binding for the Discovery of Modulators of α-Helix-Mediated Protein-Protein Interactions: Proof-of-Concept Studies with the Apoptosis Regulator Mcl-1.Targeting a dynamic protein-protein interaction: fragment screening against the malaria myosin A motor complex.Allosteric Targeting of the Fanconi Anemia Ubiquitin-Conjugating Enzyme Ube2T by Fragment Screening.Optimization of Inhibitors of Mycobacterium tuberculosis Pantothenate Synthetase Based on Group Efficiency AnalysisCurrent and emerging opportunities for molecular simulations in structure-based drug design.Fragment-based screening identifies novel targets for inhibitors of conjugative transfer of antimicrobial resistance by plasmid pKM101.Reducing the Flexibility of Type II Dehydroquinase for Inhibition: A Fragment-Based Approach and Molecular Dynamics Study.Confirmation of a Protein-Protein Interaction in the Pantothenate Biosynthetic Pathway by Using Sortase-Mediated Labelling.Target-specific NMR detection of protein-ligand interactions with antibody-relayed 15N-group selective STD.Targeting Ligandable Pockets on Plant Homeodomain (PHD) Zinc Finger Domains by a Fragment-Based Approach.Surface Probing by Fragment-Based Screening and Computational Methods Identifies Ligandable Pockets on the von Hippel-Lindau (VHL) E3 Ubiquitin LigaseSmall molecule-based targeting of TTD-A dimerization to control TFIIH transcriptional activity represents a potential strategy for anticancer therapy
P2860
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P2860
Integrated biophysical approach to fragment screening and validation for fragment-based lead discovery
description
2013 nî lūn-bûn
@nan
2013 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
Integrated biophysical approac ...... fragment-based lead discovery
@ast
Integrated biophysical approac ...... fragment-based lead discovery
@en
Integrated biophysical approac ...... fragment-based lead discovery
@nl
type
label
Integrated biophysical approac ...... fragment-based lead discovery
@ast
Integrated biophysical approac ...... fragment-based lead discovery
@en
Integrated biophysical approac ...... fragment-based lead discovery
@nl
prefLabel
Integrated biophysical approac ...... fragment-based lead discovery
@ast
Integrated biophysical approac ...... fragment-based lead discovery
@en
Integrated biophysical approac ...... fragment-based lead discovery
@nl
P2860
P50
P356
P1476
Integrated biophysical approac ...... fragment-based lead discovery
@en
P2093
Hernani Leonardo Silvestre
P2860
P304
P356
10.1073/PNAS.1304045110
P407
P577
2013-08-06T00:00:00Z