The critical role of the constant region in thermal stability and aggregation of amyloidogenic immunoglobulin light chain
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Amyloid formation in light chain amyloidosisRole of mutations in the cellular internalization of amyloidogenic light chains into cardiomyocytes.Unfolded protein response activation reduces secretion and extracellular aggregation of amyloidogenic immunoglobulin light chainIrreversible denaturation of maltodextrin glucosidase studied by differential scanning calorimetry, circular dichroism, and turbidity measurementsA strategy for synthesis of pathogenic human immunoglobulin free light chains in E. coli.Doxycycline reduces fibril formation in a transgenic mouse model of AL amyloidosis.Current perspectives on cardiac amyloidosis.The pathogenesis and diagnosis of acute kidney injury in multiple myeloma.Differential recruitment efficacy of patient-derived amyloidogenic and myeloma light chain proteins by synthetic fibrils-A metric for predicting amyloid propensity.Thermodynamic and fibril formation studies of full length immunoglobulin light chain AL-09 and its germline protein using scan rate dependent thermal unfolding.Structural Stability and Local Dynamics in Disease-Causing Mutants of Human Apolipoprotein A-I: What Makes the Protein Amyloidogenic?Systemic amyloidoses.siRNA targeting the κ light chain constant region: preclinical testing of an approach to nonfibrillar and fibrillar light chain deposition diseases.Advances in proteomic study of cardiac amyloidosis: progress and potential.Aggregation of Full-length Immunoglobulin Light Chains from Systemic Light Chain Amyloidosis (AL) Patients Is Remodeled by Epigallocatechin-3-gallate.The Kinetic Stability of a Full-Length Antibody Light Chain Dimer Determines whether Endoproteolysis Can Release Amyloidogenic Variable DomainsCell Damage in Light Chain Amyloidosis: FIBRIL INTERNALIZATION, TOXICITY AND CELL-MEDIATED SEEDING.Epigallocatechin-3-gallate preferentially induces aggregation of amyloidogenic immunoglobulin light chains.A unique case of neural amyloidoma diagnosed by mass spectrometry of formalin-fixed tissue using a novel preparative technique.Incomplete Refolding of Antibody Light Chains to Non-Native, Protease-Sensitive Conformations Leads to Aggregation: A Mechanism of Amyloidogenesis in Patients?Concurrent structural and biophysical traits link with immunoglobulin light chains amyloid propensity.Kinetic stability and sequence/structure studies of urine-derived Bence-Jones proteins from multiple myeloma and light chain amyloidosis patients.In vitro co-expression of human amyloidogenic immunoglobulin light and heavy chain proteins: a relevant cell-based model of AL amyloidosis.Systemic amyloidoses and proteomics: The state of the art.
P2860
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P2860
The critical role of the constant region in thermal stability and aggregation of amyloidogenic immunoglobulin light chain
description
2010 nî lūn-bûn
@nan
2010 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
The critical role of the const ...... nic immunoglobulin light chain
@ast
The critical role of the const ...... nic immunoglobulin light chain
@en
type
label
The critical role of the const ...... nic immunoglobulin light chain
@ast
The critical role of the const ...... nic immunoglobulin light chain
@en
prefLabel
The critical role of the const ...... nic immunoglobulin light chain
@ast
The critical role of the const ...... nic immunoglobulin light chain
@en
P2093
P2860
P356
P1433
P1476
The critical role of the const ...... nic immunoglobulin light chain
@en
P2093
David C Seldin
Elena S Klimtchuk
Kathryn L Laporte
Lawreen H Connors
Martha Skinner
Olga Gursky
Rupesh S Patel
P2860
P304
P356
10.1021/BI101351C
P407
P577
2010-10-20T00:00:00Z