Beyond natural antibodies: the power of in vitro display technologies.
about
Molecular Selection, Modification and Development of Therapeutic Oligonucleotide AptamersStable long-term cultures of self-renewing B cells and their applicationsBeyond phage display: non-traditional applications of the filamentous bacteriophage as a vaccine carrier, therapeutic biologic, and bioconjugation scaffold.Specific in vivo knockdown of protein function by intrabodiesOpportunities for functional selectivity in GPCR antibodiesFilamentous bacteriophage fd as an antigen delivery system in vaccinationDrugs derived from phage display: from candidate identification to clinical practiceSomatic hypermutation maintains antibody thermodynamic stability during affinity maturationComputational design of ligand-binding proteins with high affinity and selectivityReconciling the Structural Attributes of Avian AntibodiesProspects and challenges of CRISPR/Cas genome editing for the study and control of neglected vector-borne nematode diseasesSynthetic approach to the generation of antibody diversityA roadmap to generate renewable protein binders to the human proteomeHigh-throughput analysis of peptide-binding modulesSuppression of p75 neurotrophin receptor surface expression with intrabodies influences Bcl-xL mRNA expression and neurite outgrowth in PC12 cellsAptamer Base: a collaborative knowledge base to describe aptamers and SELEX experimentsAdvances in Antibody DesignSelection of recombinant anti-SH3 domain antibodies by high-throughput phage display.Cross-Neutralising Nanobodies Bind to a Conserved Pocket in the Hemagglutinin Stem Region Identified Using Yeast Display and Deep Mutational Scanning.Using phage display selected antibodies to dissect microbiomes for complete de novo genome sequencing of low abundance microbes.Specific binder for Lightning-LinkĀ® biotinylated proteins from an antibody phage libraryThe promise and challenge of high-throughput sequencing of the antibody repertoire.Use of periplasmic target protein capture for phage display engineering of tight-binding protein-protein interactions.A systematic approach to identify novel cancer drug targets using machine learning, inhibitor design and high-throughput screening.Expression of recombinant multi-coloured fluorescent antibodies in gor -/trxB- E. coli cytoplasm.Discovery of internalizing antibodies to tumor antigens from phage libraries.Methodologies for the isolation of alternative binders with improved clinical potentiality over conventional antibodies.Synthetic antibodies as tools to probe RNA-binding protein function.Delivery of antibodies to the cytosol: debunking the myths.Bacterial cytoplasm as an effective cell compartment for producing functional VHH-based affinity reagents and Camelidae IgG-like recombinant antibodiesDeltaPhage--a novel helper phage for high-valence pIX phagemid display.Arrayed protein library technology for therapeutic biologic discovery.An efficient method for variable region assembly in the construction of scFv phage display libraries using independent strand amplification.From deep sequencing to actual clonesAntibody affinity maturation using yeast display with detergent-solubilized membrane proteins as antigen sourcesHapten mediated display and pairing of recombinant antibodies accelerates assay assembly for biothreat countermeasuresUsing phage and yeast display to select hundreds of monoclonal antibodies: application to antigen 85, a tuberculosis biomarker.Recombinant antibody fragments allow repeated measurements of C-reactive protein with a quartz crystal microbalance immunosensor.Selection of Ceratitis capitata (Diptera: Tephritidae) specific recombinant monoclonal phage display antibodies for prey detection analysisRational engineering of a human anti-dengue antibody through experimentally validated computational docking.
P2860
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P2860
Beyond natural antibodies: the power of in vitro display technologies.
description
2011 nĆ® lÅ«n-bĆ»n
@nan
2011 Õ©ÕøÖÕ”ÕÆÕ”Õ¶Õ« ÕÕ”ÖÕæÕ«Õ¶ Õ°ÖÕ”ÕæÕ”ÖÕ”ÕÆÕøÖÕ”Õ® Õ£Õ«ÕæÕ”ÕÆÕ”Õ¶ ÕµÖ
Õ¤ÕøÖÕ”Õ®
@hyw
2011 Õ©Õ¾Õ”ÕÆÕ”Õ¶Õ« Õ“Õ”ÖÕæÕ«Õ¶ Õ°ÖÕ”ÕæÕ”ÖÕ”ÕÆÕ¾Õ”Õ® Õ£Õ«ÕæÕ”ÕÆÕ”Õ¶ Õ°ÕøÕ¤Õ¾Õ”Õ®
@hy
2011幓ć®č«ę
@ja
2011幓č«ę
@yue
2011幓č«ę
@zh-hant
2011幓č«ę
@zh-hk
2011幓č«ę
@zh-mo
2011幓č«ę
@zh-tw
2011幓č®ŗę
@wuu
name
Beyond natural antibodies: the power of in vitro display technologies.
@ast
Beyond natural antibodies: the power of in vitro display technologies.
@en
type
label
Beyond natural antibodies: the power of in vitro display technologies.
@ast
Beyond natural antibodies: the power of in vitro display technologies.
@en
prefLabel
Beyond natural antibodies: the power of in vitro display technologies.
@ast
Beyond natural antibodies: the power of in vitro display technologies.
@en
P2860
P356
P1433
P1476
Beyond natural antibodies: the power of in vitro display technologies.
@en
P2093
John McCafferty
Sachdev Sidhu
P2860
P2888
P304
P356
10.1038/NBT.1791
P577
2011-03-01T00:00:00Z
P5875
P6179
1047787000