Hydrogen/deuterium exchange mass spectrometry for probing higher order structure of protein therapeutics: methodology and applications.
about
Dynamic Viral Glycoprotein Machines: Approaches for Probing Transient States That Drive Membrane FusionNovel Structural Approaches to Study GPCR RegulationAnalytical Aspects of Hydrogen Exchange Mass SpectrometrySpin Diffusion Editing for Structural Fingerprints of Therapeutic AntibodiesChanges in protein structure monitored by use of gas-phase hydrogen/deuterium exchangeHydrogen-deuterium exchange mass spectrometry for determining protein structural changes in drug discovery.Investigating Therapeutic Protein Structure with Diethylpyrocarbonate Labeling and Mass Spectrometry.Hydrogen Exchange Mass Spectrometry.Detection of lipid-induced structural changes of the Marburg virus matrix protein VP40 using hydrogen/deuterium exchange-mass spectrometryAn improved fast photochemical oxidation of proteins (FPOP) platform for protein therapeutics.FPOP-LC-MS/MS Suggests Differences in Interaction Sites of Amphipols and Detergents with Outer Membrane Proteins.High Resolution Mapping of Bactericidal Monoclonal Antibody Binding Epitopes on Staphylococcus aureus Antigen MntC.Probing structures of large protein complexes using zero-length cross-linking.Inhibition of CD73 AMP hydrolysis by a therapeutic antibody with a dual, non-competitive mechanism of action.Application of amide hydrogen/deuterium exchange mass spectrometry for epitope mapping in human cystatin C.MEMHDX: an interactive tool to expedite the statistical validation and visualization of large HDX-MS datasets.Mass spectrometry for the biophysical characterization of therapeutic monoclonal antibodiesConformational changes in intact dengue virus reveal serotype-specific expansion.Current approaches to fine mapping of antigen-antibody interactions.Higher order structure characterization of protein therapeutics by hydrogen/deuterium exchange mass spectrometry.HDX-MS guided drug discovery: small molecules and biopharmaceuticals.Exposing the subunit diversity and modularity of protein complexes by structural mass spectrometry approaches.Advances in ion mobility-mass spectrometry instrumentation and techniques for characterizing structural heterogeneity.Computational method allowing Hydrogen-Deuterium Exchange Mass Spectrometry at single amide Resolution.Conformational modulation of the farnesoid X receptor by prenylflavonoids: Insights from hydrogen deuterium exchange mass spectrometry (HDX-MS), fluorescence titration and molecular docking studies.Molecular and functional analysis of monoclonal antibodies in support of biologics development.Characterization of Aggregation Propensity of a Human Fc-Fusion Protein Therapeutic by Hydrogen/Deuterium Exchange Mass Spectrometry.HX-MS2 for high performance conformational analysis of complex protein states.Mass spectrometry-assisted gel-based proteomics in cancer biomarker discovery: approaches and application.Cutting-edge mass spectrometry characterization of originator, biosimilar and biobetter antibodies.Plasma-Generated OH Radical Production for Analyzing Three-Dimensional Structure in Protein Therapeutics.The future of drug discovery: enabling technologies for enhancing lead characterization and profiling therapeutic potential.The use of databases, data mining and immunoinformatics in vaccinology: where are we?Native Mass Spectrometry, Ion mobility, and Collision-Induced Unfolding Categorize Malaria Antigen/Antibody Binding.Mapping the Energetic Epitope of an Antibody/Interleukin-23 Interaction with Hydrogen/Deuterium Exchange, Fast Photochemical Oxidation of Proteins Mass Spectrometry, and Alanine Shave Mutagenesis.Orthogonal Mass Spectrometry-Based Footprinting for Epitope Mapping and Structural Characterization: The IL-6 Receptor upon Binding of Protein Therapeutics.Epitope characterization of anti-JAM-A antibodies using orthogonal mass spectrometry and surface plasmon resonance approaches.Hydrogen/deuterium exchange mass spectrometry and computational modeling reveal a discontinuous epitope of an antibody/TL1A Interaction.Current Application of Capillary Electrophoresis in Nanomaterial Characterisation and Its Potential to Characterise the Protein and Small Molecule Corona.Radical solutions: Principles and application of electron-based dissociation in mass spectrometry-based analysis of protein structure.
P2860
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P2860
Hydrogen/deuterium exchange mass spectrometry for probing higher order structure of protein therapeutics: methodology and applications.
description
2013 nî lūn-bûn
@nan
2013 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
Hydrogen/deuterium exchange ma ...... methodology and applications.
@ast
Hydrogen/deuterium exchange ma ...... methodology and applications.
@en
type
label
Hydrogen/deuterium exchange ma ...... methodology and applications.
@ast
Hydrogen/deuterium exchange ma ...... methodology and applications.
@en
prefLabel
Hydrogen/deuterium exchange ma ...... methodology and applications.
@ast
Hydrogen/deuterium exchange ma ...... methodology and applications.
@en
P2093
P2860
P1433
P1476
Hydrogen/deuterium exchange ma ...... methodology and applications.
@en
P2093
Adrienne A Tymiak
Guodong Chen
Jingjie Mo
Reb J Russell
Roxana E Iacob
P2860
P304
P356
10.1016/J.DRUDIS.2013.07.019
P577
2013-08-06T00:00:00Z