Experimental approaches to hypothetical hormones: detection of a candidate ligand of the neu protooncogene.
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Identification of heregulin, a specific activator of p185erbB2Molecular cloning and expression of an additional epidermal growth factor receptor-related geneOncogenic forms of the neu/HER2 tyrosine kinase are permanently coupled to phospholipase C gammaNeural expression and chromosomal mapping of Neu differentiation factor to 8p12-p21Medullary carcinoma is associated with expression of intercellular adhesion molecule-1. Implication to its morphology and its clinical behaviorEvidence for autocrine basis of transformation in NIH-3T3 cells transfected with met/HGF receptor geneCell-type specific interaction of Neu differentiation factor (NDF/heregulin) with Neu/HER-2 suggests complex ligand-receptor relationshipsMolecular determinants of metastatic transformation.Amplification and protein over-expression of the neu/HER-2/c-erbB-2 protooncogene in human breast carcinomas: relationship to loss of gene sequences on chromosome 17, family history and prognosisc-erbB-2 protein overexpression in breast cancer is a risk factor in patients with involved and uninvolved lymph nodes.c-erbB-2 oncoprotein expression in primary and advanced breast cancerLaminin activates the p185HER2 oncoprotein and mediates growth inhibition of breast carcinoma cellsThe role of oncogenes in drug resistance.17 beta-estradiol mimics ligand activity of the c-erbB2 protooncogene product.c-myc reverses neu-induced transformed morphology by transcriptional repression.Regulation of phosphorylation of the c-erbB-2/HER2 gene product by a monoclonal antibody and serum growth factor(s) in human mammary carcinoma cellsThe carboxy-terminal domains of erbB-2 and epidermal growth factor receptor exert different regulatory effects on intrinsic receptor tyrosine kinase function and transforming activityTransformation of NIH 3T3 cells by overexpression of the normal coding sequence of the rat neu gene.Induction of the granulocyte-macrophage colony-stimulating factor (CSF) receptor by granulocyte CSF increases the differentiative options of a murine hematopoietic progenitor cell.Negative autoregulation of the neu gene is mediated by a novel enhancer.p185c-neu and epidermal growth factor receptor associate into a structure composed of activated kinasesCharacterization of a growth factor that binds exclusively to the erbB-2 receptor and induces cellular responses.Adenovirus type 5 E1A gene products act as transformation suppressors of the neu oncogeneCarboxyl-terminal deletion and point mutations decrease the transforming potential of the activated rat neu oncogene product.Characterization of a neu/c-erbB-2 protein-specific activating factorMechanistic aspects of the opposing effects of monoclonal antibodies to the ERBB2 receptor on tumor growth.Agonistic antibodies stimulate the kinase encoded by the neu protooncogene in living cells but the oncogenic mutant is constitutively activeHeregulin activation of extracellular acidification in mammary carcinoma cells is associated with expression of HER2 and HER3.Heregulin-dependent autocrine loop regulates growth of K-ras but not erbB-2 transformed rat thyroid epithelial cells.Induction of a variety of tumors by c-erbB2 and clonal nature of lymphomas even with the mutated gene (Val659----Glu659).Epidermal growth factor-related peptides activate distinct subsets of ErbB receptors and differ in their biological activities.Nonviral gene delivery to human breast cancer cells by targeted Ad5 penton proteins.Host reaction against alginate-polylysine microcapsules containing living cells.A c-erbB-2 promoter-specific nuclear matrix protein from human breast tumor tissues mediates NF-kappaB DNA binding activity.
P2860
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P2860
Experimental approaches to hypothetical hormones: detection of a candidate ligand of the neu protooncogene.
description
1989 nî lūn-bûn
@nan
1989 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
1989 թվականի մայիսին հրատարակված գիտական հոդված
@hy
1989年の論文
@ja
1989年論文
@yue
1989年論文
@zh-hant
1989年論文
@zh-hk
1989年論文
@zh-mo
1989年論文
@zh-tw
1989年论文
@wuu
name
Experimental approaches to hyp ...... gand of the neu protooncogene.
@ast
Experimental approaches to hyp ...... gand of the neu protooncogene.
@en
type
label
Experimental approaches to hyp ...... gand of the neu protooncogene.
@ast
Experimental approaches to hyp ...... gand of the neu protooncogene.
@en
prefLabel
Experimental approaches to hyp ...... gand of the neu protooncogene.
@ast
Experimental approaches to hyp ...... gand of the neu protooncogene.
@en
P2860
P356
P1476
Experimental approaches to hyp ...... gand of the neu protooncogene.
@en
P2093
R A Weinberg
P2860
P304
P356
10.1073/PNAS.86.9.3179
P407
P577
1989-05-01T00:00:00Z