FOXO3a regulates glycolysis via transcriptional control of tumor suppressor TSC1.
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Mammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growthmTOR is a key modulator of ageing and age-related diseaseClinical significance of T cell metabolic reprogramming in cancerFOXO transcription factors throughout T cell biologyUnregulated miR-96 induces cell proliferation in human breast cancer by downregulating transcriptional factor FOXO3a.FOXO3-mTOR metabolic cooperation in the regulation of erythroid cell maturation and homeostasis.TOR and ageing: a complex pathway for a complex process.Akt requires glucose metabolism to suppress puma expression and prevent apoptosis of leukemic T cells.IKBKE phosphorylation and inhibition of FOXO3a: a mechanism of IKBKE oncogenic function.Deletion of hepatic FoxO1/3/4 genes in mice significantly impacts on glucose metabolism through downregulation of gluconeogenesis and upregulation of glycolysis.3-Bromopyruvate inhibits human gastric cancer tumor growth in nude mice via the inhibition of glycolysis.P-REX1 creates a positive feedback loop to activate growth factor receptor, PI3K/AKT and MEK/ERK signaling in breast cancer.Butein sensitizes HeLa cells to cisplatin through the AKT and ERK/p38 MAPK pathways by targeting FoxO3a.Interplay between FOXO, TOR, and Akt.3-bromopyruvate and sodium citrate target glycolysis, suppress survivin, and induce mitochondrial-mediated apoptosis in gastric cancer cells and inhibit gastric orthotopic transplantation tumor growth.Wnt/β-catenin signaling protects mouse liver against oxidative stress-induced apoptosis through the inhibition of forkhead transcription factor FoxO3.Potential role of FoxO1 and mTORC1 in the pathogenesis of Western diet-induced acneJolkinolide B induces apoptosis and inhibits tumor growth in mouse melanoma B16F10 cells by altering glycolysis.Cited2, a transcriptional modulator protein, regulates metabolism in murine embryonic stem cells.Tuberous sclerosis complex inactivation disrupts melanogenesis via mTORC1 activation.Paclitaxel-resistant cancer cell-derived secretomes elicit ABCB1-associated docetaxel cross-resistance and escape from apoptosis through FOXO3a-driven glycolytic regulation.Targeting mitochondria as a therapeutic target in cancer.Recent progress toward understanding the molecular mechanisms that regulate skeletal muscle mass.BIM, PUMA, and the achilles' heel of oncogene addiction.Genetics of breast cancer bone metastasis: a sequential multistep pattern.Metabolic Reprogramming by the PI3K-Akt-mTOR Pathway in Cancer.TRAIL is involved in CpG ODN-mediated anti-apoptotic signalsAntagonistic effects of selenium on cadmium-induced apoptosis by restoring the mitochondrial dynamic equilibrium and energy metabolism in chicken spleens.The FoxO-BNIP3 axis exerts a unique regulation of mTORC1 and cell survival under energy stress.Nuclear Akt2 opposes limbal keratinocyte stem cell self-renewal by repressing a FOXO-mTORC1 signaling pathway.microRNA-19a protects osteoblasts from dexamethasone via targeting TSC1.FoxO transcription factors in cancer metabolism.
P2860
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P2860
FOXO3a regulates glycolysis via transcriptional control of tumor suppressor TSC1.
description
2010 nî lūn-bûn
@nan
2010 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
FOXO3a regulates glycolysis via transcriptional control of tumor suppressor TSC1.
@ast
FOXO3a regulates glycolysis via transcriptional control of tumor suppressor TSC1.
@en
type
label
FOXO3a regulates glycolysis via transcriptional control of tumor suppressor TSC1.
@ast
FOXO3a regulates glycolysis via transcriptional control of tumor suppressor TSC1.
@en
prefLabel
FOXO3a regulates glycolysis via transcriptional control of tumor suppressor TSC1.
@ast
FOXO3a regulates glycolysis via transcriptional control of tumor suppressor TSC1.
@en
P2093
P2860
P356
P1476
FOXO3a regulates glycolysis via transcriptional control of tumor suppressor TSC1.
@en
P2093
Catherine A Gallo
David R Plas
Preeti Tandon
Shikha Khatri
P2860
P304
15960-15965
P356
10.1074/JBC.M110.121871
P407
P577
2010-04-06T00:00:00Z