Peptide sequencing and site-directed mutagenesis identify tyrosine-727 as the active site tyrosine of Saccharomyces cerevisiae DNA topoisomerase I.
about
Phosphorylation of DNA topoisomerase I by the c-Abl tyrosine kinase confers camptothecin sensitivityStructural characterization of SIL, a gene frequently disrupted in T-cell acute lymphoblastic leukemiaSMC1: an essential yeast gene encoding a putative head-rod-tail protein is required for nuclear division and defines a new ubiquitous protein familyIdentification of the aminocatechol A-3253 as an in vitro poison of DNA topoisomerase I from Candida albicansThe inducible elongin A elongation activation domain: structure, function and interaction with the elongin BC complexThe domain organization of human topoisomerase IBiochemical and biophysical analyses of recombinant forms of human topoisomerase IIsolation and characterization of a gene encoding DNA topoisomerase I in Drosophila melanogaster.Molluscum contagiosum virus topoisomerase: purification, activities, and response to inhibitors.SCT1 mutants suppress the camptothecin sensitivity of yeast cells expressing wild-type DNA topoisomerase I.Mapping the active-site tyrosine of vaccinia virus DNA topoisomerase I.Topoisomerase 1 provokes the formation of short deletions in repeated sequences upon high transcription in Saccharomyces cerevisiae.Role for topoisomerase 1 in transcription-associated mutagenesis in yeastTyrosyl-DNA phosphodiesterase I catalytic mutants reveal an alternative nucleophile that can catalyze substrate cleavageIdentification of contacts between topoisomerase I and its target DNA by site-specific photocrosslinkingProtein footprinting by the combined use of reversible and irreversible lysine modifications.The role of topoisomerase I in suppressing genome instability associated with a highly transcribed guanine-rich sequence is not restricted to preventing RNA:DNA hybrid accumulation.The topoisomerase I gene from Ustilago maydis: sequence, disruption and mutant phenotype.HPR1, a novel yeast gene that prevents intrachromosomal excision recombination, shows carboxy-terminal homology to the Saccharomyces cerevisiae TOP1 gene.Type II diabetes increases mitochondrial DNA mutations in the left ventricle of the Goto-Kakizaki diabetic rat.Doxorubicin induced heart failure: Phenotype and molecular mechanisms.Active site of the replication protein of the rolling circle plasmid pC194.Tyrosyl-DNA phosphodiesterase I resolves both naturally and chemically induced DNA adducts and its potential as a therapeutic target.Active site mutations in DNA topoisomerase I distinguish the cytotoxic activities of camptothecin and the indolocarbazole, rebeccamycin.A camptothecin-resistant DNA topoisomerase I mutant exhibits altered sensitivities to other DNA topoisomerase poisons.Induction of reversible complexes between eukaryotic DNA topoisomerase I and DNA-containing oxidative base damages. 7, 8-dihydro-8-oxoguanine and 5-hydroxycytosine.Induction of topoisomerase I cleavage complexes by the vinyl chloride adduct 1,N6-ethenoadenine.DNA strand transfer reactions catalyzed by vaccinia topoisomerase: hydrolysis and glycerololysis of the covalent protein-DNA intermediate.Conjugal transfer of the 5-nitroimidazole resistance plasmid pIP417 from Bacteroides vulgatus BV-17: characterization and nucleotide sequence analysis of the mobilization regionMolecular cloning of a cDNA of a camptothecin-resistant human DNA topoisomerase I and identification of mutation sites.Preferential binding of human topoisomerase I to superhelical DNA.Using yeast to understand drugs that target topoisomerases.Intramolecular synapsis of duplex DNA by vaccinia topoisomerase.Carboxyl terminal domain basic amino acids of mycobacterial topoisomerase I bind DNA to promote strand passage.A novel active DNA topoisomerase I in Leishmania donovani.Overexpression of type I topoisomerases sensitizes yeast cells to DNA damage.Effects of tumor-associated mutations on Rad54 functions.Effects of camptothecin or TOP1 overexpression on genetic stability in Saccharomyces cerevisiae.Identification of active site residues in the "GyrA" half of yeast DNA topoisomerase II.Covalent DNA binding by vaccinia topoisomerase results in unpairing of the thymine base 5' of the scissile bond.
P2860
Q24305397-07C33F36-8295-4F94-B7EE-AE8D0D10745EQ24594559-8A83708C-3066-447D-886B-BE88D63352CDQ27932753-CDB537CB-0C3D-4A7D-9466-751041DD17CDQ28368205-A9771E2C-7F3C-4CD6-891D-F2ED84B148E9Q28582367-EBC5DF90-6985-40ED-85B7-8AA363DCB69BQ28910330-8F74BF7D-D3C4-4FA0-8178-46EAEA5221BEQ28910371-150AD5E6-904D-4EBA-AA83-9CDB5D189766Q30802367-F571DE2B-8EDA-4C42-A6E4-2FB404A43E26Q33783487-64695BCA-E27C-4011-91EE-D49D06FC1E1EQ34114381-BF778331-ABC2-4B7A-9358-30E37BBABCDCQ34325217-F0E38894-1369-4560-AE1D-2C28A069AC64Q34490822-DEC37B3B-1404-4085-80F4-F449A8AD9B2AQ34490872-8E31C0B9-0FB3-41C6-806A-34A5FF6D0A52Q35172933-C38BBB80-50FE-4956-AA65-FEE5E6189858Q35900490-523B475E-4158-4334-9A82-89593E3F322AQ35946664-FC5EE96C-9776-4DE6-A0FE-3E2CCBBBF87DQ36532633-EE3B7C75-FEEE-458B-8CEE-5930615859B9Q36724522-947DA247-2EA8-4A53-A5D0-B5FF2E9EFE41Q36755129-709F9B13-74B9-459A-87D4-37FD8F6972F9Q36764406-271FE8B3-875D-461E-9587-703A560BDE88Q36912561-581B3E78-8CEE-439F-960D-F19595028D23Q37636400-D1DEC8B0-E7F2-43A7-B3C4-B42240F33937Q38261264-E9B41E3D-5424-4861-8921-CD847E14BCADQ38293789-95ACF5C9-419A-4E3D-9311-51D31333494DQ38297510-6F5D169B-7151-44CE-B7BD-6C7134816552Q38326971-086D12EF-4253-4B72-9168-5A0938B9D00CQ38332699-660EFC13-70EB-47FC-8218-8C937132833CQ39720104-87AF6498-7528-4EB6-9FCA-E3D3238F0510Q39843499-E44D11D9-4C27-4349-9F8B-41011DD3A656Q40530650-4ADBD2BA-C42C-49E9-BA2F-332463671920Q40789846-23C482CF-3D96-44D5-8D59-A1E00610EFF5Q41307831-F38CEF10-7354-4D3E-B5BE-7C377A7499C1Q41980937-59E9EEBF-94B8-4C9A-9995-99F8E9B853C9Q42571558-68E1E3E5-7111-48E6-A880-6F4260E32F41Q42688471-B27A8170-DFDA-4726-AE49-C82CFCE97DD6Q43608431-22287FE1-F8B2-46CA-994B-903B22C4A654Q44824230-E4D4CE21-7A98-4F87-94AF-6326827AB455Q47725772-F825ED9D-B005-44B9-94C6-38E228BF1A9FQ47761465-EF2F2545-0A9A-405A-9BAB-634B237D0172Q52520146-58951B79-471F-4A1A-BB7E-203549DB319F
P2860
Peptide sequencing and site-directed mutagenesis identify tyrosine-727 as the active site tyrosine of Saccharomyces cerevisiae DNA topoisomerase I.
description
1989 nî lūn-bûn
@nan
1989 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
1989 թվականի մայիսին հրատարակված գիտական հոդված
@hy
1989年の論文
@ja
1989年論文
@yue
1989年論文
@zh-hant
1989年論文
@zh-hk
1989年論文
@zh-mo
1989年論文
@zh-tw
1989年论文
@wuu
name
Peptide sequencing and site-di ...... erevisiae DNA topoisomerase I.
@ast
Peptide sequencing and site-di ...... erevisiae DNA topoisomerase I.
@en
type
label
Peptide sequencing and site-di ...... erevisiae DNA topoisomerase I.
@ast
Peptide sequencing and site-di ...... erevisiae DNA topoisomerase I.
@en
prefLabel
Peptide sequencing and site-di ...... erevisiae DNA topoisomerase I.
@ast
Peptide sequencing and site-di ...... erevisiae DNA topoisomerase I.
@en
P2093
P2860
P356
P1476
Peptide sequencing and site-di ...... erevisiae DNA topoisomerase I.
@en
P2093
P2860
P304
P356
10.1073/PNAS.86.10.3559
P407
P577
1989-05-01T00:00:00Z