AFF4, a component of the ELL/P-TEFb elongation complex and a shared subunit of MLL chimeras, can link transcription elongation to leukemia. - Wikidata - awgldk - TriplyDB

AFF4, a component of the ELL/P-TEFb elongation complex and a shared subunit of MLL chimeras, can link transcription elongation to leukemia.

AFF4, a component of the ELL/P-TEFb elongation complex and a shared subunit of MLL chimeras, can link transcription elongation to leukemia.

http://www.wikidata.org/entity/Q33857407

about

MicroRNA-34a modulates c-Myc transcriptional complexes to suppress malignancy in human prostate cancer cells The mechanism of release of P-TEFb and HEXIM1 from the 7SK snRNP by viral and cellular activators includes a conformational change in 7SK HIF1A employs CDK8-mediator to stimulate RNAPII elongation in response to hypoxia CBX8, a polycomb group protein, is essential for MLL-AF9-induced leukemogenesis The little elongation complex regulates small nuclear RNA transcription Human mediator subunit MED26 functions as a docking site for transcription elongation factors The little elongation complex functions at initiation and elongation phases of snRNA gene transcription Covalent histone modifications--miswritten, misinterpreted and mis-erased in human cancers 7SK snRNA: a noncoding RNA that plays a major role in regulating eukaryotic transcription P-TEFb goes viral Targeting histone methylation for cancer therapy: enzymes, inhibitors, biological activity and perspectives The Mediator complex: a central integrator of transcription Recent progress toward epigenetic therapies: the example of mixed lineage leukemia Hijacked in cancer: the KMT2 (MLL) family of methyltransferases Getting up to speed with transcription elongation by RNA polymerase II Chromatin signatures of cancer Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia Leukemia fusion target AF9 is an intrinsically disordered transcriptional regulator that recruits multiple partners via coupled folding and binding.The AFF4 scaffold binds human P-TEFb adjacent to HIV Tat Crystal structure of HIV-1 Tat complexed with human P-TEFb and AFF4 AFF4 binding to Tat-P-TEFb indirectly stimulates TAR recognition of super elongation complexes at the HIV promoter The super elongation complex (SEC) and MLL in development and disease.hLARP7 C-terminal domain contains an xRRM that binds the 3' hairpin of 7SK RNA Unveiling novel interactions of histone chaperone Asf1 linked to TREX-2 factors Sus1 and Thp1.Disorders of Transcriptional Regulation: An Emerging Category of Multiple Malformation Syndromes Epigenetics in Cancer: A Hematological Perspective NUCKS1, a novel Tat coactivator, plays a crucial role in HIV-1 replication by increasing Tat-mediated viral transcription on the HIV-1 LTR promoter Cracking the control of RNA polymerase II elongation by 7SK snRNP and P-TEFb The Mediator complex and transcription regulation Regulation of MYC expression and differential JQ1 sensitivity in cancer cells The leukemia-associated Mllt10/Af10-Dot1l are Tcf4/β-catenin coactivators essential for intestinal homeostasis SR proteins collaborate with 7SK and promoter-associated nascent RNA to release paused polymerase The RNA Pol II elongation factor Ell3 marks enhancers in ES cells and primes future gene activation Promoter-proximal pausing of RNA polymerase II: emerging roles in metazoans Degree of recruitment of DOT1L to MLL-AF9 defines level of H3K79 Di- and tri-methylation on target genes and transformation potential.Importance of a specific amino acid pairing for murine MLL leukemias driven by MLLT1/3 or AFF1/4 Classifying leukemia types with chromatin conformation data.Identification of commonly dysregulated genes in colorectal cancer by integrating analysis of RNA-Seq data and qRT-PCR validation.A permissive chromatin state regulated by ZFP281-AFF3 in controlling the imprinted Meg3 polycistron TEG-1 CD2BP2 controls miRNA levels by regulating miRISC stability in C. elegans and human cells

P2860

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AFF4, a component of the ELL/P-TEFb elongation complex and a shared subunit of MLL chimeras, can link transcription elongation to leukemia.

http://www.wikidata.org/entity/Q33857407

description

2010 nî lūn-bûn

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2010 թուականի Փետրուարին հրատարակուած գիտական յօդուած

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2010 թվականի փետրվարին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

@zh-hant

2010年論文

@zh-hk

2010年論文

@zh-mo

2010年論文

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2010年论文

@wuu

name

AFF4, a component of the ELL/P ...... iption elongation to leukemia.

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AFF4, a component of the ELL/P ...... iption elongation to leukemia.

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type

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AFF4, a component of the ELL/P ...... iption elongation to leukemia.

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AFF4, a component of the ELL/P ...... iption elongation to leukemia.

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AFF4, a component of the ELL/P ...... iption elongation to leukemia.

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AFF4, a component of the ELL/P ...... iption elongation to leukemia.

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AFF4, a component of the ELL/P ...... iption elongation to leukemia.

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P2093

Ali Shilatifard

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Chengqi Lin

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Edwin R Smith

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Hidehisa Takahashi

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Ka Chun Lai

http://www.w3.org/2001/XMLSchema#string

Ronald C Conaway

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Skylar Martin-Brown

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P2860

Identification, cloning, expression, and biochemical characterization of the testis-specific RNA polymerase II elongation factor ELL3

Cloning of ELL, a gene that fuses to MLL in a t(11;19)(q23;p13.1) in acute myeloid leukemia

Molecular regulation of H3K4 trimethylation by Wdr82, a component of human Set1/COMPASS

An RNA polymerase II elongation factor encoded by the human ELL gene

ELL-associated factors 1 and 2 are positive regulators of RNA polymerase II elongation factor ELL

RNA polymerase stalling at developmental control genes in the Drosophila melanogaster embryo

The molecular basis of eukaryotic transcription

hDOT1L links histone methylation to leukemogenesis.

ELL2, a new member of an ELL family of RNA polymerase II elongation factors

EAF1, a novel ELL-associated factor that is delocalized by expression of the MLL-ELL fusion protein

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429-437

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3

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37

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Laurence Florens

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Joan W. Conaway

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2010-02-01T00:00:00Z

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41451358

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20159561

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