CBX8, a polycomb group protein, is essential for MLL-AF9-induced leukemogenesis
about
Mechanisms of epigenetic regulation of leukemia onset and progressionRecent progress toward epigenetic therapies: the example of mixed lineage leukemiaHijacked in cancer: the KMT2 (MLL) family of methyltransferasesHigh-affinity, small-molecule peptidomimetic inhibitors of MLL1/WDR5 protein-protein interactionEmerging concepts of epigenetic dysregulation in hematological malignanciesInvestigation of the relationship between chromobox homolog 8 and nucleus pulposus cells degeneration in rat intervertebral discEZH2 and BCL6 Cooperate to Assemble CBX8-BCOR Complex to Repress Bivalent Promoters, Mediate Germinal Center Formation and LymphomagenesisDegree of recruitment of DOT1L to MLL-AF9 defines level of H3K79 Di- and tri-methylation on target genes and transformation potential.Importance of a specific amino acid pairing for murine MLL leukemias driven by MLLT1/3 or AFF1/4A cellular chemical probe targeting the chromodomains of Polycomb repressive complex 1Chromatin modifications as therapeutic targets in MLL-rearranged leukemia.Epigenetic regulation by polycomb group complexes: focus on roles of CBX proteinsThe Polycomb complex PRC2 supports aberrant self-renewal in a mouse model of MLL-AF9;Nras(G12D) acute myeloid leukemia.Polycomb and trithorax opposition in development and disease.CBX8, a novel DNA repair protein, promotes tumorigenesis in human esophageal carcinoma.Requirement for CDK6 in MLL-rearranged acute myeloid leukemia.Genotranscriptomic meta-analysis of the Polycomb gene CBX2 in human cancers: initial evidence of an oncogenic role.The molecular mechanics of mixed lineage leukemia.Identification of hidden relationships from the coupling of hydrophobic cluster analysis and domain architecture information.Paradoxical role of CBX8 in proliferation and metastasis of colorectal cancer.Two decades of leukemia oncoprotein epistasis: the MLL1 paradigm for epigenetic deregulation in leukemia.A Cbx8-containing polycomb complex facilitates the transition to gene activation during ES cell differentiation.Mutated Ptpn11 alters leukemic stem cell frequency and reduces the sensitivity of acute myeloid leukemia cells to Mcl1 inhibition.MLL-AF9- and HOXA9-mediated acute myeloid leukemia stem cell self-renewal requires JMJD1C.Histone H2B ubiquitin ligase RNF20 is required for MLL-rearranged leukemia.The trithorax protein partner menin acts in tandem with EZH2 to suppress C/EBPα and differentiation in MLL-AF9 leukemia.Differential role of Id1 in MLL-AF9-driven leukemia based on cell of origin.MLL1 and MLL1 fusion proteins have distinct functions in regulating leukemic transcription programCbx8 Acts Non-canonically with Wdr5 to Promote Mammary Tumorigenesis.CBX8, a component of the Polycomb PRC1 complex, modulates DOT1L-mediated gene expression through AF9/MLLT3Epigenetic roles of MLL oncoproteins are dependent on NF-κBChanges of bivalent chromatin coincide with increased expression of developmental genes in cancerMLL-Rearranged Leukemias-An Update on Science and Clinical Approaches.MLL-AF4 binds directly to a BCL-2 specific enhancer and modulates H3K27 acetylationPolycomb-group proteins in hematopoietic stem cell regulation and hematopoietic neoplasms.In focus: MLL-rearranged leukemia.Interplay between the cancer genome and epigenome.Molecular and Epigenetic Mechanisms of MLL in Human Leukemogenesis.Mechanisms of mixed-lineage leukemia.Chromatin modifiers and the promise of epigenetic therapy in acute leukemia
P2860
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P2860
CBX8, a polycomb group protein, is essential for MLL-AF9-induced leukemogenesis
description
2011 nî lūn-bûn
@nan
2011 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
CBX8, a polycomb group protein, is essential for MLL-AF9-induced leukemogenesis
@ast
CBX8, a polycomb group protein, is essential for MLL-AF9-induced leukemogenesis
@en
CBX8, a polycomb group protein, is essential for MLL-AF9-induced leukemogenesis
@en-gb
CBX8, a polycomb group protein, is essential for MLL-AF9-induced leukemogenesis
@nl
type
label
CBX8, a polycomb group protein, is essential for MLL-AF9-induced leukemogenesis
@ast
CBX8, a polycomb group protein, is essential for MLL-AF9-induced leukemogenesis
@en
CBX8, a polycomb group protein, is essential for MLL-AF9-induced leukemogenesis
@en-gb
CBX8, a polycomb group protein, is essential for MLL-AF9-induced leukemogenesis
@nl
prefLabel
CBX8, a polycomb group protein, is essential for MLL-AF9-induced leukemogenesis
@ast
CBX8, a polycomb group protein, is essential for MLL-AF9-induced leukemogenesis
@en
CBX8, a polycomb group protein, is essential for MLL-AF9-induced leukemogenesis
@en-gb
CBX8, a polycomb group protein, is essential for MLL-AF9-induced leukemogenesis
@nl
P2093
P2860
P3181
P1433
P1476
CBX8, a polycomb group protein, is essential for MLL-AF9-induced leukemogenesis
@en
P2093
Andrew G Muntean
Jay L Hess
Jiaying Tan
Manabu Nakayama
Morgan Jones
P2860
P304
P3181
P356
10.1016/J.CCR.2011.09.008
P407
P577
2011-11-01T00:00:00Z