Specific calpain inhibition by calpastatin prevents tauopathy and neurodegeneration and restores normal lifespan in tau P301L mice - Wikidata - awgldk - TriplyDB

Specific calpain inhibition by calpastatin prevents tauopathy and neurodegeneration and restores normal lifespan in tau P301L mice

Specific calpain inhibition by calpastatin prevents tauopathy and neurodegeneration and restores normal lifespan in tau P301L mice

http://www.wikidata.org/entity/Q33865294

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Cysteine proteases as therapeutic targets: does selectivity matter? A systematic review of calpain and cathepsin inhibitors The Role of MAPT in Neurodegenerative Diseases: Genetics, Mechanisms and Therapy Calpain inhibition mediates autophagy-dependent protection against polyglutamine toxicity.Tau deposition drives neuropathological, inflammatory and behavioral abnormalities independently of neuronal loss in a novel mouse model Erythropoietin Modulates Cerebral and Serum Degradation Products from Excess Calpain Activation following Prenatal Hypoxia-Ischemia.Calpastatin inhibits motor neuron death and increases survival of hSOD1(G93A) mice.Tau pathology-mediated presynaptic dysfunction Prions and Protein Assemblies that Convey Biological Information in Health and Disease.Calpain-1 and Calpain-2: The Yin and Yang of Synaptic Plasticity and Neurodegeneration.Degradomics in Neurotrauma: Profiling Traumatic Brain Injury.Therapeutic strategies for the treatment of tauopathies: Hopes and challenges.Amyloid precursor protein and endosomal-lysosomal dysfunction in Alzheimer's disease: inseparable partners in a multifactorial disease.Novel Selective Calpain 1 Inhibitors as Potential Therapeutics in Alzheimer's Disease.Specific calpain inhibition protects kidney against inflammaging.NH2-truncated human tau induces deregulated mitophagy in neurons by aberrant recruitment of Parkin and UCHL-1: implications in Alzheimer's disease.MRNA Levels of ACh-Related Enzymes in the Hippocampus of THY-Tau22 Mouse: A Model of Human Tauopathy with No Signs of Motor Disturbance.The twenty-four KDa C-terminal tau fragment increases with aging in tauopathy mice: implications of prion-like properties.Axonal Degeneration in Tauopathies: Disease Relevance and Underlying Mechanisms.Tau-based therapies in neurodegeneration: opportunities and challenges.Inhibition of p25/Cdk5 Attenuates Tauopathy in Mouse and iPSC Models of Frontotemporal Dementia.Calcium Dysregulation in Alzheimer's Disease: A Target for New Drug Development.Less is more: Caloric regulation of neurogenesis and adult brain function.Blast waves from detonated military explosive reduce GluR1 and synaptophysin levels in hippocampal slice cultures.Dysfunction of autophagy and endosomal-lysosomal pathways: Roles in pathogenesis of Down syndrome and Alzheimer's Disease.Tau Proteolysis in the Pathogenesis of Tauopathies: Neurotoxic Fragments and Novel Biomarkers.Analyzing the Behavior of Neuronal Pathways in Alzheimer's Disease Using Petri Net Modeling Approach.Homocysteine-lowering gene therapy rescues signaling pathways in brain of mice with intermediate hyperhomocysteinemia

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P2860

Specific calpain inhibition by calpastatin prevents tauopathy and neurodegeneration and restores normal lifespan in tau P301L mice

http://www.wikidata.org/entity/Q33865294

description

2014 nî lūn-bûn

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2014 թուականի Յուլիսին հրատարակուած գիտական յօդուած

@hyw

2014 թվականի հուլիսին հրատարակված գիտական հոդված

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2014年の論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年论文

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name

Specific calpain inhibition by ...... mal lifespan in tau P301L mice

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Specific calpain inhibition by ...... mal lifespan in tau P301L mice

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type

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Specific calpain inhibition by ...... mal lifespan in tau P301L mice

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Specific calpain inhibition by ...... mal lifespan in tau P301L mice

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Specific calpain inhibition by ...... mal lifespan in tau P301L mice

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P356

JNEUROSCI.1132-14.2014

P1433

Journal of Neuroscience

P1476

Specific calpain inhibition by ...... mal lifespan in tau P301L mice

@en

P2093

Asok Kumar

http://www.w3.org/2001/XMLSchema#string

Audrey Hashim

http://www.w3.org/2001/XMLSchema#string

Henry Sershen

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Jabbar Campbell

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Mary Kate McBrayer

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Masuo Ohno

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Michael Hutton

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Philip H Stavrides

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Ralph A Nixon

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P2860

Cdk5: multitasking between physiological and pathological conditions

Caspase cleavage of tau: linking amyloid and neurofibrillary tangles in Alzheimer's disease

Genome-wide atlas of gene expression in the adult mouse brain

Mechanisms of protein seeding in neurodegenerative diseases

Lysosomal dysfunction promotes cleavage and neurotoxicity of tau in vivo

Structure-based design of non-natural amino-acid inhibitors of amyloid fibril formation

Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model

Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration

Neurotoxicity induces cleavage of p35 to p25 by calpain

Association of missense and 5'-splice-site mutations in tau with the inherited dementia FTDP-17

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9222-9234

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10.1523/JNEUROSCI.1132-14.2014

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28

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4087203

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