Partial diversion of a mutant proinsulin (B10 aspartic acid) from the regulated to the constitutive secretory pathway in transfected AtT-20 cells.
about
INS-gene mutations: from genetics and beta cell biology to clinical diseasePancreatic β-Cell Adaptive Plasticity in Obesity Increases Insulin Production but Adversely Affects Secretory Function.Expression and secretion of human proinsulin-B10 from mouse salivary glands: implications for the treatment of type I diabetes mellitus.A transgene coding for a human insulin analog has a mitogenic effect on murine embryonic beta cellsProinsulin endoproteolysis confers enhanced targeting of processed insulin to the regulated secretory pathwayTopographic abnormalities of proinsulin to insulin conversion in functioning human insulinomas. Comparison of immunoelectron microscopic and clinical data.Evidence for defects in membrane traffic in Paramecium secretory mutants unable to produce functional storage granules.Intracellular transport and sorting of mutant human proinsulins that fail to form hexamers.P-selectin, a granule membrane protein of platelets and endothelial cells, follows the regulated secretory pathway in AtT-20 cells.Engineering of glucose-stimulated insulin secretion and biosynthesis in non-islet cells.Diabetes mellitus due to the toxic misfolding of proinsulin variants.Insulin granule biogenesis, trafficking and exocytosis.Insulin-secreting non-islet cells are resistant to autoimmune destruction.Insulin therapy in diabetes and cancer risk: current understanding and implications for future study: proceedings from a meeting of a European Insulin Safety Consensus Panel, convened and sponsored by Novo Nordisk, held Tuesday October 5, 2010 at ThInsulin gene mutations and diabetesMutant proinsulin proteins associated with neonatal diabetes are retained in the endoplasmic reticulum and not efficiently secretedProteasome inhibition alters glucose-stimulated (pro)insulin secretion and turnover in pancreatic {beta}-cells.Biogenesis of von Willebrand factor-containing organelles in heterologous transfected CV-1 cells.Genetic engineering of glucose-stimulated insulin secretion in Chinese hamster ovary cells.Sorting Ourselves Out: Seeking Consensus on Trafficking in the Beta-Cell
P2860
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P2860
Partial diversion of a mutant proinsulin (B10 aspartic acid) from the regulated to the constitutive secretory pathway in transfected AtT-20 cells.
description
1989 nî lūn-bûn
@nan
1989 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
1989 թվականի հունիսին հրատարակված գիտական հոդված
@hy
1989年の論文
@ja
1989年論文
@yue
1989年論文
@zh-hant
1989年論文
@zh-hk
1989年論文
@zh-mo
1989年論文
@zh-tw
1989年论文
@wuu
name
Partial diversion of a mutant ...... y in transfected AtT-20 cells.
@ast
Partial diversion of a mutant ...... y in transfected AtT-20 cells.
@en
type
label
Partial diversion of a mutant ...... y in transfected AtT-20 cells.
@ast
Partial diversion of a mutant ...... y in transfected AtT-20 cells.
@en
prefLabel
Partial diversion of a mutant ...... y in transfected AtT-20 cells.
@ast
Partial diversion of a mutant ...... y in transfected AtT-20 cells.
@en
P2093
P2860
P356
P1476
Partial diversion of a mutant ...... y in transfected AtT-20 cells.
@en
P2093
L Villa-Komaroff
P A Halban
P2860
P304
P356
10.1073/PNAS.86.11.4107
P407
P577
1989-06-01T00:00:00Z