A mutation in the B chain coding region is associated with impaired proinsulin conversion in a family with hyperproinsulinemia.
about
INS-gene mutations: from genetics and beta cell biology to clinical diseaseCharacterization of insulins and proglucagon-derived peptides from a phylogenetically ancient fish, the paddlefish (Polyodon spathula)Expression and secretion of human proinsulin-B10 from mouse salivary glands: implications for the treatment of type I diabetes mellitus.A mutant human proinsulin is secreted from islets of Langerhans in increased amounts via an unregulated pathwayPartial diversion of a mutant proinsulin (B10 aspartic acid) from the regulated to the constitutive secretory pathway in transfected AtT-20 cells.A superactive insulin: [B10-aspartic acid]insulin(human).SNAP predicts effect of mutations on protein function.Defective processing of insulin-receptor precursor in cultured lymphocytes from a patient with extreme insulin resistance.Topographic abnormalities of proinsulin to insulin conversion in functioning human insulinomas. Comparison of immunoelectron microscopic and clinical data.New roles of carboxypeptidase E in endocrine and neural function and cancer.Intracellular transport and sorting of mutant human proinsulins that fail to form hexamers.Mass spectrometric immunoassay of intact insulin and related variants for population proteomics studies.Diabetes mellitus due to the toxic misfolding of proinsulin variants.The regulated secretory pathway and human disease: insights from gene variants and single nucleotide polymorphisms.Regulation of insulin synthesis and secretion and pancreatic Beta-cell dysfunction in diabetes.Behavior in the eukaryotic secretory pathway of insulin-containing fusion proteins and single-chain insulins bearing various B-chain mutations.Expression of the ZIP/SLC39A transporters in β-cells: a systematic review and integration of multiple datasets.Differential kinetics of rat insulin I and II processing in rat islets of Langerhans.Human sex reversal due to impaired nuclear localization of SRY. A clinical correlation.
P2860
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P2860
A mutation in the B chain coding region is associated with impaired proinsulin conversion in a family with hyperproinsulinemia.
description
1987 nî lūn-bûn
@nan
1987 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
1987 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
1987年の論文
@ja
1987年論文
@yue
1987年論文
@zh-hant
1987年論文
@zh-hk
1987年論文
@zh-mo
1987年論文
@zh-tw
1987年论文
@wuu
name
A mutation in the B chain codi ...... mily with hyperproinsulinemia.
@ast
A mutation in the B chain codi ...... mily with hyperproinsulinemia.
@en
A mutation in the B chain codi ...... mily with hyperproinsulinemia.
@nl
type
label
A mutation in the B chain codi ...... mily with hyperproinsulinemia.
@ast
A mutation in the B chain codi ...... mily with hyperproinsulinemia.
@en
A mutation in the B chain codi ...... mily with hyperproinsulinemia.
@nl
prefLabel
A mutation in the B chain codi ...... mily with hyperproinsulinemia.
@ast
A mutation in the B chain codi ...... mily with hyperproinsulinemia.
@en
A mutation in the B chain codi ...... mily with hyperproinsulinemia.
@nl
P2093
P2860
P356
P1476
A mutation in the B chain codi ...... mily with hyperproinsulinemia.
@en
P2093
P2860
P304
P356
10.1073/PNAS.84.8.2194
P407
P577
1987-04-01T00:00:00Z