Efficient synthetic inhibitors of anthrax lethal factor. - Wikidata - awgldk - TriplyDB

Efficient synthetic inhibitors of anthrax lethal factor.

Efficient synthetic inhibitors of anthrax lethal factor.

http://www.wikidata.org/entity/Q33868811

about

Anthrax toxin lethal factor domain 3 is highly mobile and responsive to ligand binding Targeting host cell furin proprotein convertases as a therapeutic strategy against bacterial toxins and viral pathogens Lethal and edema toxins in the pathogenesis of Bacillus anthracis septic shock: implications for therapy Identification of a surrogate marker for infection in the African green monkey model of inhalation anthrax Importance of explicit smeared lone-pairs in anisotropic polarizable molecular mechanics. Torture track angular tests for exchange-repulsion and charge transfer contributions.Identification of novel non-hydroxamate anthrax toxin lethal factor inhibitors by topomeric searching, docking and scoring, and in vitro screening.Cationic polyamines inhibit anthrax lethal factor protease A high-throughput screening approach to anthrax lethal factor inhibition.Chelator fragment libraries for targeting metalloproteinases.A semi-synthetic ion channel platform for detection of phosphatase and protease activity.Targeting Bacillus anthracis toxicity with a genetically selected inhibitor of the PA/CMG2 protein-protein interaction Identification and characterization of novel inhibitors of Mammalian aspartyl aminopeptidase Proteasome inhibitors prevent caspase-1-mediated disease in rodents challenged with anthrax lethal toxin.Selective small molecule inhibition of poly(ADP-ribose) glycohydrolase (PARG).Rhodanine as a scaffold in drug discovery: a critical review of its biological activities and mechanisms of target modulation.Emerging principles in protease-based drug discovery.Development of a comprehensive, validated pharmacophore hypothesis for anthrax toxin lethal factor (LF) inhibitors using genetic algorithms, Pareto scoring, and structural biology.Identification of exosite-targeting inhibitors of anthrax lethal factor by high-throughput screening Detection of anthrax toxin in the serum of animals infected with Bacillus anthracis by using engineered immunoassays Perspectives on NMR in drug discovery: a technique comes of age Identification of toxin inhibitors using a magnetic nanosensor-based assay.Highly predictive support vector machine (SVM) models for anthrax toxin lethal factor (LF) inhibitors.Inhibitors of the Metalloproteinase Anthrax Lethal Factor.Statistical analysis, optimization, and prioritization of virtual screening parameters for zinc enzymes including the anthrax toxin lethal factor.Identification of novel anthrax toxin countermeasures using in silico methods.Ligand-induced expansion of the S1' site in the anthrax toxin lethal factor A decade of fragment-based drug design: strategic advances and lessons learned.New insights into the pathogenesis and treatment of anthrax toxin-induced shock.Potential biological targets of Bacillus anthracis in anti-infective approaches against the threat of bioterrorism.Small-molecule inhibitors of lethal factor protease activity protect against anthrax infection.Thioamide hydroxypyrothiones supersede amide hydroxypyrothiones in potency against anthrax lethal factor Small molecule inhibitors of anthrax lethal factor toxin Targeting bacterial toxins.Anthrax lethal factor protease inhibitors: synthesis, SAR, and structure-based 3D QSAR studies.An overview of investigational toxin-directed therapies for the adjunctive management of Bacillus anthracis infection and sepsis.Identification of a Substrate-selective Exosite within the Metalloproteinase Anthrax Lethal Factor.Fluorine NMR-based screening on cell membrane extracts.Observations on screening-based research and some concerning trends in the literature.A structure-based approach to retinoid X receptor-alpha inhibition.A novel pharmacophore model for the design of anthrax lethal factor inhibitors.

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Efficient synthetic inhibitors of anthrax lethal factor.

http://www.wikidata.org/entity/Q33868811

description

2005 nî lūn-bûn

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2005 թուականի Յունիսին հրատարակուած գիտական յօդուած

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2005 թվականի հունիսին հրատարակված գիտական հոդված

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2005年の論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年论文

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name

Efficient synthetic inhibitors of anthrax lethal factor.

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Efficient synthetic inhibitors of anthrax lethal factor.

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Efficient synthetic inhibitors of anthrax lethal factor.

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Efficient synthetic inhibitors of anthrax lethal factor.

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Efficient synthetic inhibitors of anthrax lethal factor.

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Efficient synthetic inhibitors of anthrax lethal factor.

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Proceedings of the National Academy of Sciences of the United States of America

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Efficient synthetic inhibitors of anthrax lethal factor.

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Alexei Y Savinov

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Andrew J Orry

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Dawoon Jung

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Dmitri V Rozanov

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Jeffrey W Smith

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Ken Alibek

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Maurizio Pellecchia

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Robert C Liddington

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Ruben A Abagyan

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Sherida Johnson

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P2860

A Common Mechanism Underlying Promiscuous Inhibitors from Virtual and High-Throughput Screening

Susceptibility of mitogen-activated protein kinase kinase family members to proteolysis by anthrax lethal factor

Human capillary morphogenesis protein 2 functions as an anthrax toxin receptor

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

Crystal structure of the anthrax lethal factor

The structural basis for substrate and inhibitor selectivity of the anthrax lethal factor

Identification of small molecule inhibitors of anthrax lethal factor

Crystal structure of the anthrax toxin protective antigen

Identification of the cellular receptor for anthrax toxin

Observations on experimental anthrax; demonstration of a specific lethal factor produced in vivo by Bacillus anthracis

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27

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102

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Roberto Fattorusso

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