about
Engineering of TEV protease variants by yeast ER sequestration screening (YESS) of combinatorial librariesNatural Inhibitors of Snake Venom Metalloendopeptidases: History and Current ChallengesGenetically Engineered Mouse Models Reveal the Importance of Proteases as Osteoarthritis Drug TargetsProtease signalling: the cutting edgeTargeting BCL2-Proteins for the Treatment of Solid TumoursMechanistic and Structural Understanding of Uncompetitive Inhibitors of Caspase-6Proteolysis inside the Membrane Is a Rate-Governed Reaction Not Driven by Substrate AffinityOptimization of triazine nitriles as rhodesain inhibitors: structure-activity relationships, bioisosteric imidazopyridine nitriles, and X-ray crystal structure analysis with human cathepsin LOxadiazole-Based Cell Permeable Macrocyclic Transition State Inhibitors of Norovirus 3CL ProteaseN-Arylacyl O-sulfonated aminoglycosides as novel inhibitors of human neutrophil elastase, cathepsin G and proteinase 3Mycobacterium tuberculosis ClpP1 and ClpP2 function together in protein degradation and are required for viability in vitro and during infectionAllosteric regulation of rhomboid intramembrane proteolysisA global comparison of the human and T. brucei degradomes gives insights about possible parasite drug targetsNetwork analyses reveal pervasive functional regulation between proteases in the human protease webInhibition of Plasmepsin V activity demonstrates its essential role in protein export, PfEMP1 display, and survival of malaria parasitesProtease inhibitors from marine actinobacteria as a potential source for antimalarial compoundProperties of protein drug target classesDistinct OGT-Binding Sites Promote HCF-1 CleavageCharacterizing Protease Specificity: How Many Substrates Do We Need?Modifying the substrate specificity of Carcinoscorpius rotundicauda serine protease inhibitor domain 1 to target thrombinMorphologic, Phylogenetic and Chemical Characterization of a Brackish Colonial Picocyanobacterium (Coelosphaeriaceae) with Bioactive PropertiesAcquisition of accurate data from intramolecular quenched fluorescence protease assays.ModBase, a database of annotated comparative protein structure models and associated resources.Factor V activator from Daboia russelli russelli venom destabilizes β-amyloid aggregate, the hallmark of Alzheimer disease.Dual-functional, receptor-targeted fluorogenic probe for in vivo imaging of extracellular protease expressionsDesign of Protease Activated Optical Contrast Agents That Exploit a Latent Lysosomotropic Effect for Use in Fluorescence-Guided Surgery.Plant Proteinase Inhibitor BbCI Modulates Lung Inflammatory Responses and Mechanic and Remodeling Alterations Induced by Elastase in Mice.Identification of Tight-Binding Plasmepsin II and Falcipain 2 Inhibitors in Aqueous Extracts of Marine Invertebrates by the Combination of Enzymatic and Interaction-Based Assays.Light-up probe based on AIEgens: dual signal turn-on for caspase cascade activation monitoringMatrix Metalloproteinase Gene Activation Resulting from Disordred Epigenetic Mechanisms in Rheumatoid Arthritis.Robust substrate profiling method reveals striking differences in specificities of serum and lung fluid proteases.Targeting zymogen activation to control the matriptase-prostasin proteolytic cascade.Mechanism and specificity of the human paracaspase MALT1.Proteolytic activity of prostate-specific antigen (PSA) towards protein substrates and effect of peptides stimulating PSA activityIdentification of exosite-targeting inhibitors of anthrax lethal factor by high-throughput screeningPericellular proteolysis in cancerAAA+ chaperones and acyldepsipeptides activate the ClpP protease via conformational control.An integrated approach to the ligand binding specificity of Neisseria meningitidis M1 alanine aminopeptidase by fluorogenic substrate profiling, inhibitory studies and molecular modeling.Analysis of tumour- and stroma-supplied proteolytic networks reveals a brain-metastasis-promoting role for cathepsin SCleavage entropy as quantitative measure of protease specificity.
P2860
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P2860
description
2010 nî lūn-bûn
@nan
2010 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Emerging principles in protease-based drug discovery.
@ast
Emerging principles in protease-based drug discovery.
@en
Emerging principles in protease-based drug discovery.
@nl
type
label
Emerging principles in protease-based drug discovery.
@ast
Emerging principles in protease-based drug discovery.
@en
Emerging principles in protease-based drug discovery.
@nl
prefLabel
Emerging principles in protease-based drug discovery.
@ast
Emerging principles in protease-based drug discovery.
@en
Emerging principles in protease-based drug discovery.
@nl
P2860
P356
P1476
Emerging principles in protease-based drug discovery.
@en
P2093
Guy S Salvesen
Marcin Drag
P2860
P2888
P304
P356
10.1038/NRD3053
P577
2010-09-01T00:00:00Z