Targeting RNA foci in iPSC-derived motor neurons from ALS patients with a C9ORF72 repeat expansion
about
Quo vadis motor neuron disease?There has been an awakening: Emerging mechanisms of C9orf72 mutations in FTD/ALSToward precision medicine in amyotrophic lateral sclerosisThe Use of Stem Cells to Model Amyotrophic Lateral Sclerosis and Frontotemporal Dementia: From Basic Research to Regenerative MedicineInduced Pluripotent Stem Cells as a Novel Tool in Psychiatric ResearchEpigenetic Research of Neurodegenerative Disorders Using Patient iPSC-Based ModelsALS Patient Stem Cells for Unveiling Disease Signatures of Motoneuron Susceptibility: Perspectives on the Deadly Mitochondria, ER Stress and Calcium TriadModeling ALS and FTD with iPSC-derived neuronsMotor neuron derivation from human embryonic and induced pluripotent stem cells: experimental approaches and clinical perspectivesRAN translation and frameshifting as translational challenges at simple repeats of human neurodegenerative disordersThe Potential for iPS-Derived Stem Cells as a Therapeutic Strategy for Spinal Cord Injury: Opportunities and ChallengesiPSC-Based Models to Unravel Key Pathogenetic Processes Underlying Motor Neuron Disease DevelopmentTherapeutic and diagnostic challenges for frontotemporal dementiaInduced pluripotent stem cells from ALS patients for disease modelingStem cells in the nervous systemPathways disrupted in human ALS motor neurons identified through genetic correction of mutant SOD1.Cell-based screening: extracting meaning from complex data.Modeling diseases of noncoding unstable repeat expansions using mutant pluripotent stem cells.Modeling ALS with motor neurons derived from human induced pluripotent stem cellsA perspective on stem cell modeling of amyotrophic lateral sclerosisEmerging mechanisms of molecular pathology in ALSUtilizing induced pluripotent stem cells (iPSCs) to understand the actions of estrogens in human neuronsRNA-mediated pathogenic mechanisms in polyglutamine diseases and amyotrophic lateral sclerosisInduced Pluripotent Stem Cell Models to Enable In Vitro Models for Screening in the Central Nervous SystemRNA-targeted Therapeutics for ALSG-quadruplexes: Emerging roles in neurodegenerative diseases and the non-coding transcriptomeThe C9orf72 repeat expansion disrupts nucleocytoplasmic transport.Reliable generation of induced pluripotent stem cells from human lymphoblastoid cell lines.A Novel Protocol for Directed Differentiation of C9orf72-Associated Human Induced Pluripotent Stem Cells Into Contractile Skeletal Myotubes.Genetic Correction of SOD1 Mutant iPSCs Reveals ERK and JNK Activated AP1 as a Driver of Neurodegeneration in Amyotrophic Lateral Sclerosis.C9ORF72 hexanucleotide repeat exerts toxicity in a stable, inducible motor neuronal cell model, which is rescued by partial depletion of Pten.C9orf72 nucleotide repeat structures initiate molecular cascades of disease.RNA metabolism in neurodegenerative disease.Modelling amyotrophic lateral sclerosis: progress and possibilitiesSequestration of multiple RNA recognition motif-containing proteins by C9orf72 repeat expansionsPatient-derived skeletal dysplasia induced pluripotent stem cells display abnormal chondrogenic marker expression and regulation by BMP2 and TGFβ1Human induced pluripotent stem cells are a novel source of neural progenitor cells (iNPCs) that migrate and integrate in the rodent spinal cord.Mouse Models of C9orf72 Hexanucleotide Repeat Expansion in Amyotrophic Lateral Sclerosis/ Frontotemporal DementiaSRSF1-dependent nuclear export inhibition of C9ORF72 repeat transcripts prevents neurodegeneration and associated motor deficits.Molecular network analysis suggests a logical hypothesis for the pathological role of c9orf72 in amyotrophic lateral sclerosis/frontotemporal dementia.
P2860
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P2860
Targeting RNA foci in iPSC-derived motor neurons from ALS patients with a C9ORF72 repeat expansion
description
2013 nî lūn-bûn
@nan
2013 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
Targeting RNA foci in iPSC-der ...... ith a C9ORF72 repeat expansion
@ast
Targeting RNA foci in iPSC-der ...... ith a C9ORF72 repeat expansion
@en
type
label
Targeting RNA foci in iPSC-der ...... ith a C9ORF72 repeat expansion
@ast
Targeting RNA foci in iPSC-der ...... ith a C9ORF72 repeat expansion
@en
prefLabel
Targeting RNA foci in iPSC-der ...... ith a C9ORF72 repeat expansion
@ast
Targeting RNA foci in iPSC-der ...... ith a C9ORF72 repeat expansion
@en
P2093
P2860
P4510
P1476
Targeting RNA foci in iPSC-der ...... ith a C9ORF72 repeat expansion
@en
P2093
A K M G Muhammad
Anais Sahabian
C Frank Bennett
Clive N Svendsen
Dhruv Sareen
Frank Rigo
Jacqueline G O'Rourke
John Ravits
Loren Ornelas
Matthew B Harms
P2860
P304
P356
10.1126/SCITRANSLMED.3007529
P407
P577
2013-10-01T00:00:00Z