Centrosome duplication in mammalian somatic cells requires E2F and Cdk2-cyclin A.
about
Centrosome dysfunction contributes to chromosome instability, chromoanagenesis, and genome reprograming in cancerCyclin A2 mutagenesis analysis: a new insight into CDK activation and cellular localization requirementsPolo-like kinase 4: the odd one out of the familyCentrobin: a novel daughter centriole-associated protein that is required for centriole duplicationCentrobin-tubulin interaction is required for centriole elongation and stabilityCalcium- and integrin-binding protein 1 regulates microtubule organization and centrosome segregation through polo like kinase 3 during cell cycle progressionA novel role of human holliday junction resolvase GEN1 in the maintenance of centrosome integrityPolo-like kinase 2-dependent phosphorylation of NPM/B23 on serine 4 triggers centriole duplicationRoles of BRCA1 in centrosome duplicationCep152 acts as a scaffold for recruitment of Plk4 and CPAP to the centrosomeCDK6 associates with the centrosome during mitosis and is mutated in a large Pakistani family with primary microcephalyRegulation of mitotic spindle formation by the RhoA guanine nucleotide exchange factor ARHGEF10The ATAC acetyl transferase complex controls mitotic progression by targeting non-histone substrates.Cyclin F-mediated degradation of ribonucleotide reductase M2 controls genome integrity and DNA repairSAS-6 defines a protein family required for centrosome duplication in C. elegans and in human cellsAurora-A overexpression reveals tetraploidization as a major route to centrosome amplification in p53-/- cellsHuman Mps1 kinase is required for the spindle assembly checkpoint but not for centrosome duplicationRapamycin potentiates transforming growth factor beta-induced growth arrest in nontransformed, oncogene-transformed, and human cancer cells.The centrosomal kinase Aurora-A/STK15 interacts with a putative tumor suppressor NM23-H1.Nonperiodic activity of the human anaphase-promoting complex-Cdh1 ubiquitin ligase results in continuous DNA synthesis uncoupled from mitosisThe forkhead-associated domain protein Cep170 interacts with Polo-like kinase 1 and serves as a marker for mature centriolesRegulated HsSAS-6 levels ensure formation of a single procentriole per centriole during the centrosome duplication cycleAb ovo or de novo? Mechanisms of centriole duplicationWhen 2+2=5: the origins and fates of aneuploid and tetraploid cellsCyclin G2 is a centrosome-associated nucleocytoplasmic shuttling protein that influences microtubule stability and induces a p53-dependent cell cycle arrestExpression of cyclins A, E and topoisomerase II alpha correlates with centrosome amplification and genomic instability and influences the reliability of cytometric S-phase determinationInvolvement of an SCFSlmb complex in timely elimination of E2F upon initiation of DNA replication in Drosophilap16(INK4a) prevents centrosome dysfunction and genomic instability in primary cells.Ciliogenesis and the DNA damage response: a stressful relationshipThe PLK4-STIL-SAS-6 module at the core of centriole duplicationCentrosome - a promising anti-cancer targetCentriolar satellites assemble centrosomal microcephaly proteins to recruit CDK2 and promote centriole duplicationCell Cycle-Dependent Localization of Dynactin Subunit p150 glued at CentrosomePathways governing G1/S transition and their response to DNA damageCompensation of BRG-1 function by Brm: insight into the role of the core SWI-SNF subunits in retinoblastoma tumor suppressor signalingPhosphorylation-dependent and -independent functions of p130 cooperate to evoke a sustained G1 block.Targeted disruption of Skp2 results in accumulation of cyclin E and p27(Kip1), polyploidy and centrosome overduplicationIn Silico Identification and In Vitro and In Vivo Validation of Anti-Psychotic Drug Fluspirilene as a Potential CDK2 Inhibitor and a Candidate Anti-Cancer DrugFra-1 promotes growth and survival in RAS-transformed thyroid cells by controlling cyclin A transcriptionComponents of an SCF ubiquitin ligase localize to the centrosome and regulate the centrosome duplication cycle
P2860
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P2860
Centrosome duplication in mammalian somatic cells requires E2F and Cdk2-cyclin A.
description
1999 nî lūn-bûn
@nan
1999 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի հունիսին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Centrosome duplication in mammalian somatic cells requires E2F and Cdk2-cyclin A.
@ast
Centrosome duplication in mammalian somatic cells requires E2F and Cdk2-cyclin A.
@en
type
label
Centrosome duplication in mammalian somatic cells requires E2F and Cdk2-cyclin A.
@ast
Centrosome duplication in mammalian somatic cells requires E2F and Cdk2-cyclin A.
@en
prefLabel
Centrosome duplication in mammalian somatic cells requires E2F and Cdk2-cyclin A.
@ast
Centrosome duplication in mammalian somatic cells requires E2F and Cdk2-cyclin A.
@en
P2093
P356
P1433
P1476
Centrosome duplication in mammalian somatic cells requires E2F and Cdk2-cyclin A
@en
P2093
P2888
P356
10.1038/10054
P577
1999-06-01T00:00:00Z
P6179
1036536776