about
Intercellular transfer of oncogenic H-Ras at the immunological synapseActivation of RasGRP3 by phosphorylation of Thr-133 is required for B cell receptor-mediated Ras activationT cell activationRasGRF2, a guanosine nucleotide exchange factor for Ras GTPases, participates in T-cell signaling responsesUnusual interplay of two types of Ras activators, RasGRP and SOS, establishes sensitive and robust Ras activation in lymphocytesMolecular mechanisms and functional implications of polarized actin remodeling at the T cell immunological synapseIdentification of a new transmembrane adaptor protein that constitutively binds Grb2 in B cellsInositol (1,4,5) trisphosphate 3 kinase B controls positive selection of T cells and modulates Erk activityB-Raf is required for positive selection and survival of DP cells, but not for negative selection of SP cellsGrap negatively regulates T-cell receptor-elicited lymphocyte proliferation and interleukin-2 induction.One-way membrane trafficking of SOS in receptor-triggered Ras activation.Mechanism of SOS PR-domain autoinhibition revealed by single-molecule assays on native protein from lysate.Dynamic palmitoylation and the role of DHHC proteins in T cell activation and anergy.PD-1 immunoreceptor inhibits B cell receptor-mediated signaling by recruiting src homology 2-domain-containing tyrosine phosphatase 2 to phosphotyrosine.Ras inhibition induces insulin sensitivity and glucose uptake.A bistable model of cell polarity.Negative regulation of Rap1 activation by the Cbl E3 ubiquitin ligase.Primary murine CD4+ T cells fail to acquire the ability to produce effector cytokines when active Ras is present during Th1/Th2 differentiation.Transgenic analysis of thymocyte signal transduction.Regulation of alternative pre-mRNA splicing by the ERK MAP-kinase pathwayDigital signaling and hysteresis characterize ras activation in lymphoid cells.GTPases and T cell activation.Lck regulates the threshold of activation in primary T cells, while both Lck and Fyn contribute to the magnitude of the extracellular signal-related kinase response.Cell-cycle regulation of T-cell responses--novel approaches to the control of alloimmunity.The membrane environment can promote or suppress bistability in cell signaling networks.Activation of mitogen-activated protein kinase kinase (MEK)/extracellular signal regulated kinase (ERK) signaling pathway is involved in myeloid lineage commitment.Farnesyltransferase inhibitors inhibit T-cell cytokine production at the posttranscriptional level.A phospholipase C-γ1-independent, RasGRP1-ERK-dependent pathway drives lymphoproliferative disease in linker for activation of T cells-Y136F mutant mice.The RAS guanyl nucleotide-releasing protein RasGRP1 is involved in lymphatic development in zebrafish.Endothelial nitric oxide synthase regulates N-Ras activation on the Golgi complex of antigen-stimulated T cellsThe Ras GTPase-activating protein neurofibromin 1 promotes the positive selection of thymocytes.Signaling by small GTPases in the immune system.K-RasG12D-induced T-cell lymphoblastic lymphoma/leukemias harbor Notch1 mutations and are sensitive to gamma-secretase inhibitors.Notch1 gene mutations target KRAS G12D-expressing CD8+ cells and contribute to their leukemogenic transformation.Activation of extracellular signal-regulated kinase but not of p38 mitogen-activated protein kinase pathways in lymphocytes requires allosteric activation of SOS.Origin of the sharp boundary that discriminates positive and negative selection of thymocytesOncogenic Kras-induced leukemogeneis: hematopoietic stem cells as the initial target and lineage-specific progenitors as the potential targets for final leukemic transformation.T cell Receptor Signal Transduction in T lymphocytes.Bam32: a novel mediator of Erk activation in T cells.Ras activation in Jurkat T cells following low-grade stimulation of the T-cell receptor is specific to N-Ras and occurs only on the Golgi apparatus.
P2860
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P2860
description
2000 nî lūn-bûn
@nan
2000 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
Ras regulation and function in lymphocytes.
@ast
Ras regulation and function in lymphocytes.
@en
type
label
Ras regulation and function in lymphocytes.
@ast
Ras regulation and function in lymphocytes.
@en
prefLabel
Ras regulation and function in lymphocytes.
@ast
Ras regulation and function in lymphocytes.
@en
P1476
Ras regulation and function in lymphocytes
@en
P2093
D A Cantrell
P304
P356
10.1016/S0952-7915(00)00089-3
P577
2000-06-01T00:00:00Z