Distinct recruitment and function of Gab1 and Gab2 in Met receptor-mediated epithelial morphogenesis. - Wikidata - awgldk - TriplyDB

Distinct recruitment and function of Gab1 and Gab2 in Met receptor-mediated epithelial morphogenesis.

Distinct recruitment and function of Gab1 and Gab2 in Met receptor-mediated epithelial morphogenesis.

http://www.wikidata.org/entity/Q33899291

about

Function, regulation and pathological roles of the Gab/DOS docking proteins Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein Pak4, a novel Gab1 binding partner, modulates cell migration and invasion by the Met receptor Gab2 phosphorylation by RSK inhibits Shp2 recruitment and cell motility Met receptor tyrosine kinase signals through a cortactin-Gab1 scaffold complex, to mediate invadopodia Membrane targeting of Grb2-associated binder-1 (Gab1) scaffolding protein through Src myristoylation sequence substitutes for Gab1 pleckstrin homology domain and switches an epidermal growth factor response to an invasive morphogenic program.Gab1 is required for cell cycle transition, cell proliferation, and transformation induced by an oncogenic met receptor.c-Jun N-terminal Kinase 2 Regulates Multiple Receptor Tyrosine Kinase Pathways in Mouse Mammary Tumor Growth and Metastasis.Negative feedback of T cell activation through inhibitory adapters and costimulatory receptors.The role of the c-Met pathway in lung cancer and the potential for targeted therapy.From Tpr-Met to Met, tumorigenesis and tubes.GAB2 induces tumor angiogenesis in NRAS-driven melanoma.Novel role for p21-activated kinase 2 in thrombin-induced monocyte migration.Distinct involvement of the Gab1 and Grb2 adaptor proteins in signal transduction by the related receptor tyrosine kinases RON and MET.The Tyrosine Kinome Dictates Breast Cancer Heterogeneity and Therapeutic Responsiveness.Increased levels of Gab1 and Gab2 adaptor proteins skew interleukin-4 (IL-4) signaling toward M2 macrophage-driven pulmonary fibrosis in mice.Cleavage of Grb2-Associated Binding Protein 2 by Viral Proteinase 2A during Coxsackievirus Infection.Alterations of Gab2 signalling complexes in imatinib and dasatinib treated chronic myeloid leukaemia cells.Participation of both Gab1 and Gab2 in the activation of the ERK/MAPK pathway by epidermal growth factor.Extracellular Signal-Regulated Kinases 1 and 2 Phosphorylate Gab2 To Promote a Negative-Feedback Loop That Attenuates Phosphoinositide 3-Kinase/Akt Signaling Anti-apoptotic role of caspase-cleaved GAB1 adaptor protein in hepatocyte growth factor/scatter factor-MET receptor protein signaling.GGA3 functions as a switch to promote Met receptor recycling, essential for sustained ERK and cell migration.Distinct recruitment of Eps15 via Its coiled-coil domain is required for efficient down-regulation of the met receptor tyrosine kinase.Gab docking proteins in cardiovascular disease, cancer, and inflammation.Participation of Gab1 and Gab2 in IL-22-mediated keratinocyte proliferation, migration, and differentiation.Footprints of recent selection and variability in breed composition in the Göttingen Minipig genome.

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P2860

Distinct recruitment and function of Gab1 and Gab2 in Met receptor-mediated epithelial morphogenesis.

http://www.wikidata.org/entity/Q33899291

description

2002 nî lūn-bûn

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2002 թուականի Յունիսին հրատարակուած գիտական յօդուած

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2002 թվականի հունիսին հրատարակված գիտական հոդված

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2002年の論文

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2002年論文

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2002年論文

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2002年論文

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2002年論文

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2002年論文

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2002年论文

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name

Distinct recruitment and funct ...... ated epithelial morphogenesis.

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Distinct recruitment and funct ...... ated epithelial morphogenesis.

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type

label

Distinct recruitment and funct ...... ated epithelial morphogenesis.

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Distinct recruitment and funct ...... ated epithelial morphogenesis.

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Distinct recruitment and funct ...... ated epithelial morphogenesis.

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Distinct recruitment and funct ...... ated epithelial morphogenesis.

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MBC.02-02-0031.

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Molecular Biology of the Cell

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Distinct recruitment and funct ...... ated epithelial morphogenesis.

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Christiane R Maroun

http://www.w3.org/2001/XMLSchema#string

Lisa S Lock

http://www.w3.org/2001/XMLSchema#string

Monica A Naujokas

http://www.w3.org/2001/XMLSchema#string

Morag Park

http://www.w3.org/2001/XMLSchema#string

P2860

Identification of major tyrosine phosphorylation sites in the human insulin receptor substrate Gab-1 by insulin receptor kinase in vitro

Determination of Gab1 (Grb2-associated binder-1) interaction with insulin receptor-signaling molecules

Novel recognition motif on fibroblast growth factor receptor mediates direct association and activation of SNT adapter proteins

p62(dok): a constitutively tyrosine-phosphorylated, GAP-associated protein in chronic myelogenous leukemia progenitor cells

Grb10 interacts differentially with the insulin receptor, insulin-like growth factor I receptor, and epidermal growth factor receptor via the Grb10 Src homology 2 (SH2) domain and a second novel domain located between the pleckstrin homology and SH2

A Grb2-associated docking protein in EGF- and insulin-receptor signalling

Identification and analysis of PH domain-containing targets of phosphatidylinositol 3-kinase using a novel in vivo assay in yeast.

PKB-mediated negative feedback tightly regulates mitogenic signalling via Gab2.

Dok-3, a novel adapter molecule involved in the negative regulation of immunoreceptor signaling

FRS2 proteins recruit intracellular signaling pathways by binding to diverse targets on fibroblast growth factor and nerve growth factor receptors

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2132-2146

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scholarly article

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10.1091/MBC.02-02-0031.

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6

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13

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12058075

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117630

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