A genome-wide RNA interference screen reveals an essential CREB3L2-ATF5-MCL1 survival pathway in malignant glioma with therapeutic implications. - Wikidata - awgldk - TriplyDB

A genome-wide RNA interference screen reveals an essential CREB3L2-ATF5-MCL1 survival pathway in malignant glioma with therapeutic implications.

A genome-wide RNA interference screen reveals an essential CREB3L2-ATF5-MCL1 survival pathway in malignant glioma with therapeutic implications.

http://www.wikidata.org/entity/Q33900952

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Nucleophosmin (NPM1/B23) interacts with activating transcription factor 5 (ATF5) protein and promotes proteasome- and caspase-dependent ATF5 degradation in hepatocellular carcinoma cells BCL-2 is a downstream target of ATF5 that mediates the prosurvival function of ATF5 in a cell type-dependent manner The role of Bcl-2 family proteins in therapy responses of malignant astrocytic gliomas: Bcl2L12 and beyond Transcription factor ATF5 is required for terminal differentiation and survival of olfactory sensory neurons A machine learning classifier trained on cancer transcriptomes detects NF1 inactivation signal in glioblastoma Regulated ATF5 loss-of-function in adult mice blocks formation and causes regression/eradication of gliomas Human cytomegalovirus immediate-early protein promotes survival of glioma cells through interacting and acetylating ATF5 Human cytomegalovirus inhibits apoptosis by regulating the activating transcription factor 5 signaling pathway in human malignant glioma cells.Suppression of peroxiredoxin 4 in glioblastoma cells increases apoptosis and reduces tumor growth.An activating transcription factor 5-mediated survival pathway as a target for cancer therapy?CXCR7 is induced by hypoxia and mediates glioma cell migration towards SDF-1α p300-Dependent ATF5 acetylation is essential for Egr-1 gene activation and cell proliferation and survival.BCR-ABL suppresses autophagy through ATF5-mediated regulation of mTOR transcription Genome-wide approaches for cancer gene discovery.Activating transcription factor 5 enhances radioresistance and malignancy in cancer cells.Vigilance and validation: Keys to success in RNAi screening.Combined inhibition of Bcl-2/Bcl-xL and Usp9X/Bag3 overcomes apoptotic resistance in glioblastoma in vitro and in vivo.DNA methylation level of promoter region of activating transcription factor 5 in glioma.Association between human cytomegalovirus infection and histone acetylation level in various histological types of glioma.Hepatitis B virus X protein represses miRNA-148a to enhance tumorigenesis.A phase I study of the combination of sorafenib with temozolomide and radiation therapy for the treatment of primary and recurrent high-grade gliomas Knock-Down of Endogenous Bornavirus-Like Nucleoprotein 1 Inhibits Cell Growth and Induces Apoptosis in Human Oligodendroglia Cells.Gene expression analysis uncovers novel hedgehog interacting protein (HHIP) effects in human bronchial epithelial cells Regression/eradication of gliomas in mice by a systemically-deliverable ATF5 dominant-negative peptide.Connexin 43 Inhibition Sensitizes Chemoresistant Glioblastoma Cells to Temozolomide.Inhibition of receptor signaling and of glioblastoma-derived tumor growth by a novel PDGFRβ aptamer.ATRX loss promotes tumor growth and impairs nonhomologous end joining DNA repair in glioma.Targeting mitochondria as a therapeutic target in cancer.A novel lentivirus for quantitative assessment of gene knockdown in stem cell differentiation.Programming cancer cells for high expression levels of Mcl1.Targeting intrinsic apoptosis and other forms of cell death by BH3-mimetics in glioblastoma.Revealing protein networks and gene-drug connectivity in cancer from direct information.Sorafenib Sensitizes Glioma Cells to the BH3 Mimetic ABT-737 by Targeting MCL1 in a STAT3-Dependent Manner Distinctive responses of brain tumor cells to TLR2 ligands.PARP inhibition restores extrinsic apoptotic sensitivity in glioblastoma.Preclinical antitumor efficacy of selective exportin 1 inhibitors in glioblastoma.Mitochondrial dysfunction in cancer: Potential roles of ATF5 and the mitochondrial UPR.Notch1 signaling promotes survival of glioblastoma cells via EGFR-mediated induction of anti-apoptotic Mcl-1.Type I IFNs signaling and apoptosis resistance in glioblastoma cells.The Transcription Factor ATF5 Mediates a Mammalian Mitochondrial UPR

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A genome-wide RNA interference screen reveals an essential CREB3L2-ATF5-MCL1 survival pathway in malignant glioma with therapeutic implications.

http://www.wikidata.org/entity/Q33900952

description

2010 nî lūn-bûn

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2010 թուականի Մայիսին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի մայիսին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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name

A genome-wide RNA interference ...... with therapeutic implications.

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A genome-wide RNA interference ...... with therapeutic implications.

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type

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A genome-wide RNA interference ...... with therapeutic implications.

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A genome-wide RNA interference ...... with therapeutic implications.

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prefLabel

A genome-wide RNA interference ...... with therapeutic implications.

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A genome-wide RNA interference ...... with therapeutic implications.

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Nature Medicine

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A genome-wide RNA interference ...... with therapeutic implications.

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Alonzo H Ross

http://www.w3.org/2001/XMLSchema#string

Andrea Demers

http://www.w3.org/2001/XMLSchema#string

Li Li

http://www.w3.org/2001/XMLSchema#string

Lihua J Zhu

http://www.w3.org/2001/XMLSchema#string

Michael R Green

http://www.w3.org/2001/XMLSchema#string

Richard P Moser

http://www.w3.org/2001/XMLSchema#string

Thomas W Smith

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Zhi Sheng

http://www.w3.org/2001/XMLSchema#string

P2860

The Hallmarks of Cancer

BBF2H7, a novel transmembrane bZIP transcription factor, is a new type of endoplasmic reticulum stress transducer

An integrated genomic analysis of human glioblastoma multiforme

Glioma stem cells promote radioresistance by preferential activation of the DNA damage response

p21-activated kinases in cancer

Second-generation shRNA libraries covering the mouse and human genomes

Inhibition of apoptosis by ATFx: a novel role for a member of the ATF/CREB family of mammalian bZIP transcription factors

A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002)

Diphtheria toxin: mode of action and structure

In vivo depletion of CD11c+ dendritic cells abrogates priming of CD8+ T cells by exogenous cell-associated antigens

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671-677

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10.1038/NM.2158

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6

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16

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2010-05-23T00:00:00Z

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44623685

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20495567

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2882506

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