Programming cancer cells for high expression levels of Mcl1.
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Early apoptosis of porcine alveolar macrophages limits avian influenza virus replication and pro-inflammatory dysregulation.Mcl-1 ubiquitination: unique regulation of an essential survival protein.Inhibition of protein phosphatase 2A (PP2A) prevents Mcl-1 protein dephosphorylation at the Thr-163/Ser-159 phosphodegron, dramatically reducing expression in Mcl-1-amplified lymphoma cells.Obatoclax overcomes resistance to cell death in aggressive thyroid carcinomas by countering Bcl2a1 and Mcl1 overexpression.B cell lymphoma-2 (BCL-2) homology domain 3 (BH3) mimetics demonstrate differential activities dependent upon the functional repertoire of pro- and anti-apoptotic BCL-2 family proteins.Wnt modulates MCL1 to control cell survival in triple negative breast cancer.Obatoclax is a direct and potent antagonist of membrane-restricted Mcl-1 and is synthetic lethal with treatment that induces Bim.Inhibition of Mcl-1 with the pan-Bcl-2 family inhibitor (-)BI97D6 overcomes ABT-737 resistance in acute myeloid leukemia.Synergistic induction of apoptosis in high-risk DLBCL by BCL2 inhibition with ABT-199 combined with pharmacologic loss of MCL1Cyclin E/Cdk2-dependent phosphorylation of Mcl-1 determines its stability and cellular sensitivity to BH3 mimeticsA Hippo and Fibroblast Growth Factor Receptor Autocrine Pathway in CholangiocarcinomamiR-29b and miR-198 overexpression in CD8+ T cells of renal cell carcinoma patients down-modulates JAK3 and MCL-1 leading to immune dysfunction.N-(3-oxo-acyl) homoserine lactone inhibits tumor growth independent of Bcl-2 proteins.Molecular profiling of the residual disease of triple-negative breast cancers after neoadjuvant chemotherapy identifies actionable therapeutic targets.Dynamic survey of mitochondria by ubiquitin.Noxa and cancer therapy: Tuning up the mitochondrial death machinery in response to chemotherapy.EGF-mediated induction of Mcl-1 at the switch to lactation is essential for alveolar cell survival.miR-204 mediated loss of Myeloid cell leukemia-1 results in pancreatic cancer cell death.The RNA-binding protein tristetraprolin schedules apoptosis of pathogen-engaged neutrophils during bacterial infection.BH3 mimetic Obatoclax (GX15-070) mediates mitochondrial stress predominantly via MCL-1 inhibition and induces autophagy-dependent necroptosis in human oral cancer cells.Piceatannol induced apoptosis through up-regulation of microRNA-181a in melanoma cells.FBW7 increases the chemosensitivity of pancreatic cancer cells to gemcitabine through upregulation of ENT1.The prognostic significance of MCL1 copy number gain in esophageal squamous cell carcinoma.Intergenic disease-associated regions are abundant in novel transcripts.Pharmacological Rac1 inhibitors with selective apoptotic activity in human acute leukemic cell lines.Long noncoding RNA PVT1 inhibits renal cancer cell apoptosis by up-regulating Mcl-1.Myocardin and Stat3 act synergistically to inhibit cardiomyocyte apoptosis.SYK inhibition thwarts the BAFF - B-cell receptor crosstalk and thereby antagonizes Mcl-1 in chronic lymphocytic leukemia.MiR-29 silencing modulates the expression of target genes related to proliferation, apoptosis and methylation in Burkitt lymphoma cells.Caspase cleavage of Mcl-1 impairs its anti-apoptotic activity and proteasomal degradation in non-small lung cancer cells.LncRNA NEAT1 promotes dexamethasone resistance in multiple myeloma by targeting miR-193a/MCL1 pathway.Telomeres: Implications for Cancer Development.
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P2860
Programming cancer cells for high expression levels of Mcl1.
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article científic
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article scientifique
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articol științific
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articolo scientifico
@it
artigo científico
@gl
artigo científico
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artigo científico
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artikel ilmiah
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artikull shkencor
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artículo científico
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name
Programming cancer cells for high expression levels of Mcl1.
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type
label
Programming cancer cells for high expression levels of Mcl1.
@en
prefLabel
Programming cancer cells for high expression levels of Mcl1.
@en
P2093
P2860
P356
P1433
P1476
Programming cancer cells for high expression levels of Mcl1.
@en
P2093
Anne Roulston
Franziska Ertel
Gordon C Shore
Mai Nguyen
P2860
P304
P356
10.1038/EMBOR.2013.20
P577
2013-03-12T00:00:00Z